Stories About the Origin of Quinquina and Quinidine

Anti-breast cancer activity of some novel quinoline derivatives

“…IR spectra (KBr disc) were recorded using an FT-IR spectrophotometer (Perkin Elmer, USA). 1 H NMR spectra were scanned on a NMR spectrophotometer (Bruker AXS Inc., Switzerland), operating at 500 MHz for 1 H-and 125.76 MHz for 13 C NMR. Chemical shift s are expressed in d values (ppm) relative to TMS as an internal standard, using DMSO-d 6 as a solvent.…”

“…The corresponding 2-cyano-3-(4-hydroxy-3-methoxyphenyl)-N-(quinolin-3-yl) acrylamide (15), 3-oxo-N-(quinolin-3-yl)-3H-benzol[f ] chromene-2-carboxamide (27), 2-cyano-3-(4-fl uorophenyl-N-(quinolin-3-yl) acrylamide (7), 2-cyano-5-(4-(di meth ylamino) phenyl)-N-(quinolin-3-yl) penta-2,4-dienamide (19) , resp. Also, quinoline acrylamides containing 2,3,4-trimethoxyphenyl 17, 2-chlorophenyl 10, benzo[d] [1,3]dioxol 12, 2-methoxynaphthalen 22, 2,4-dichlorophenyl 18 and quinoline carrying a chromene-3-carboxamide moiety 25 were nearly as active as doxorubicin, while quinoline acrylamides incorporating unsubstituted phenyl 2, p-tolyl 3, 2,4-dienamide 8, 3-nitrophenyl 13, 4-nitrophenyl 14, 3,4-dimethoxyphenyl 16 and chromene 26 exhibited a moderate activity. In addition, quinoline with acetamide 1, 4-hydroxyphenyl 4, 4-dimethylaminophenyl 9, 4-chlorophenyl 11, 3-bromophenyl 20, 4-bromophenyl 21 and 3-thienyl moiety 24 showed less activity than doxorubicin.…”

1,1′-{1,4-Phenylene bis[3-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-4,5-dihydro-1H-pyrazole-5,1-diyl]}dibutan-1-one

“…All IR spectra were performed on Shimadzu FT-IR-8201 PC spectrophotometer (Constantine, Algeria) and only significant absorption-band frequency is cited. 1 H-NMR and 13 C-NMR spectra were recorded in deuterated chloroform on a Brüker Avance DPX 250 spectrometer (Constantine, Algeria) at 250 MHz for proton and at 62.9 MHz for 13 C. Chemical shifts are given in ppm and J values in Hertz (Hz). The mass spectrum was scanned on a Shimadzu GCMS-QP2010 and the elemental analysis was obtained using a LECO CHNS-900 elemental analyzer (Lyon, France) and the values are within ±0.4% of the theoretical values.…”

“…Indeed quinoline derivatives are some of the oldest compounds which have been utilized for the treatment of a variety of diseases; the bark of Cinchona plants containing quinine has been utilized to treat palpitations [1]. Compounds containing quinoline motif are most widely used as antimalarials [2], antibacterials [3], antifungals [4] and anticancer agents [5].…”

Synthesis, Crystal Structures, Hydrogen Bonds and Antibacterial Activity of New Quinoline Derivatives

“…The bark of Cinchona plant containing quinine was utilized to treat palpitations [3] fevers and tertians since more than 200 years ago. Quinoline, a diastereoisomer of quinine was in the early twentieth century acknowledged as the most potent of the antiarrhythmic compounds isolated from the Cinchona plant [4].…”