Storage parameters affecting red blood cell survival and function after transfusion

Högman, Claes F.; Meryman, Harold T.

doi:10.1016/s0887-7963(99)80058-3

Cited by 180 publications

(180 citation statements)

References 78 publications

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“…These changes include a decrease in 2,3-diphosphoglycerate, adenosine triphosphate, and S-nitrosohemoglobin as well as an increase in the concentrations of lactate, potassium, cytokines, iron, and free hemoglobin in the supernatant. [22][23][24][25][26] Red blood cells also Continuous variables are presented as median [interquartile range], categorical variables as number (percent). CABG = coronary artery bypass graft; RBC = red blood cell; CPB = cardiopulmonary bypass; AKI = acute kidney injury The model also adjusted for the Cleveland risk score and site.…”

Section: Discussionmentioning

confidence: 99%

Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study

Karkouti

Grocott

Hall

et al. 2014

Can J Anesth/J Can Anesth

137

100

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Section: Discussionmentioning

confidence: 99%

Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study

Karkouti

Grocott

Hall

et al. 2014

Can J Anesth/J Can Anesth

137

100

View full text Add to dashboard Cite

“…It has been proven that the transfusion of damaged RBCs can cause severe problems to body tissue and, in some cases, may lead to death. [5][6][7][8][9] A typical human erythrocyte RBC has a diameter of ∼6.4 to 7.76 μm 10 and thickness of 2 to 3 μm at its thickest point. 11 The surface area of adult mature RBCs is 140 μm 2 .…”

Section: Introductionmentioning

confidence: 99%

Automated three-dimensional morphology-based clustering of human erythrocytes with regular shapes: stomatocytes, discocytes, and echinocytes

et al. 2017

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Inkyu Moon, "Automated three-dimensional morphologybased clustering of human erythrocytes with regular shapes: stomatocytes, discocytes, and echinocytes," J. Biomed. Opt. 22(7), 076015 (2017), doi: 10.1117/1.JBO.22.7.076015. Abstract. We present unsupervised clustering methods for automatic grouping of human red blood cells (RBCs) extracted from RBC quantitative phase images obtained by digital holographic microscopy into three RBC clusters with regular shapes, including biconcave, stomatocyte, and sphero-echinocyte. We select some good features related to the RBC profile and morphology, such as RBC average thickness, sphericity coefficient, and mean corpuscular volume, and clustering methods, including density-based spatial clustering applications with noise, k-medoids, and k -means, are applied to the set of morphological features. The clustering results of RBCs using a set of three-dimensional features are compared against a set of two-dimensional features. Our experimental results indicate that by utilizing the introduced set of features, two groups of biconcave RBCs and old RBCs (suffering from the sphero-echinocyte process) can be perfectly clustered. In addition, by increasing the number of clusters, the three RBC types can be effectively clustered in an automated unsupervised manner with high accuracy. The performance evaluation of the clustering techniques reveals that they can assist hematologists in further diagnosis. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Second, anticoagulant agents present in blood bags are also responsible for the decrease of pH. The changes in lactate and pH values can potentially lead to various complications in patients with renal and hepatic pathologies, and in pediatric and senile patients (18,19). Generally, a high concentration of dextrose is added to blood preservation solutions (as it is in CPD) in order to support erythrocyte metabolic processes; therefore, an increased glucose concentration at the initial state of blood storage is expected (18).…”

Section: Discussionmentioning

confidence: 99%

A new utilization area for hyperbaric oxygen? Improving quality of stored blood

Ay¹,

Yüksel²,

Şimşek³

et al. 2015

Turk J Med Sci

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Background/aim: Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood. Materials and methods:Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week.Results: Glucose and pH levels decreased in stored blood. In the HBO-exposed group, these decreases were less than in the control. In addition, mean corpuscular and platelet volumes tended to increase during storing process, but with HBO, these indexes remained lower, near physiologic levels. Another interesting finding of the study was the relative stable osmotic fragility ratio in the HBO group compared to the control blood. Conclusion:HBO exposure has positive effects on pH, stability of erythrocytes, and energy source (glucose) of the medium. Thus, we concluded that HBO may be a useful application for life and quality of stored blood.

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Storage parameters affecting red blood cell survival and function after transfusion

Cited by 180 publications

References 78 publications

Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study

Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study

Automated three-dimensional morphology-based clustering of human erythrocytes with regular shapes: stomatocytes, discocytes, and echinocytes

A new utilization area for hyperbaric oxygen? Improving quality of stored blood

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