Storage of platelets in additive solutions: a multicentre study of the <i>in vitro</i> effects of potassium and magnesium

Gulliksson, H.; AuBuchon, James P.; Cardigan, Rebecca; Meer, Pieter F. van der; Murphy, Scott; Prowse, C. V.; Richter, Ekkehard; Ringwald, Juergen; Smacchia, C.; Slichter, Sherrill J.; Wildt‐Eggen, J. de

doi:10.1046/j.1423-0410.2003.00356.x

Cited by 81 publications

(97 citation statements)

References 12 publications

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“…Regarding the last limitation, additive solutions have been developed that can attenuate PLT activation. Adding magnesium and potassium ions to the commercial additive solutions PASII and PASIII completely prevented PLT activation, as evidenced by comparable levels of CD62p expression, BMR release, glucose consumption and lactate production (de Wildt-Eggen et al, 2002;Gulliksson et al, 2003;Shanwell et al, 2003). In addition, M-sol, which contains magnesium and potassium ions, reportedly has attenuating effects on PLT activation (Hirayama et al, 2007).…”

Section: Plasma-reduced (Or Concentrated) Plts and Washed Pltsmentioning

confidence: 99%

Current Understanding of Allergic Transfusion Reactions: Incidence, Pathogenesis, Laboratory Tests, Prevention and Treatment

文也¹

2013

JJTC

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SummaryNon-haemolytic transfusion reactions are the most common type of transfusion reaction and include transfusion-related acute lung injury, transfusion-associated circulatory overload, allergic reactions, febrile reactions, post-transfusion purpura and graft-versus-host disease. Although life-threatening anaphylaxis occurs rarely, allergic reactions occur most frequently. If possible, even mild transfusion reactions should be avoided because they add to patients' existing suffering. During the last decade, several new discoveries have been made in the field of allergic diseases and transfusion medicine. First, mast cells are not the only cells that are key players in allergic diseases, particularly in the murine immune system. Second, it has been suggested that immunologically active undigested or digested food allergens in a donor's blood may be transferred to a recipient who is allergic to these antigens, causing anaphylaxis. Third, washed platelets have been shown to be effective for preventing allergic transfusion reactions, although substantial numbers of platelets are lost during washing procedures, and platelet recovery after transfusion may not be equivalent to that with unwashed platelets. This review describes allergic transfusion reactions, including the above-mentioned points, and focusses on their incidence, pathogenesis, laboratory tests, prevention and treatment.

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Section: Plasma-reduced (Or Concentrated) Plts and Washed Pltsmentioning

confidence: 99%

Current Understanding of Allergic Transfusion Reactions: Incidence, Pathogenesis, Laboratory Tests, Prevention and Treatment

文也¹

2013

JJTC

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“…Furthermore, improvements in platelet storage, such as second-generation storage containers with better O 2 /CO 2 exchange and bigger platelet storage volumes stabilize pH values, resulted in better platelet viability [4, 12–14]. Storage of platelets in synthetic media (platelet additive solutions) may further reduce platelet metabolic rate and inhibit platelet activation during storage [15–17]. Although the usage of platelet additive solutions may be successful, this assessment is mostly based on in vitro studies.…”

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confidence: 99%

Novel and unexpected clearance mechanisms for cold platelets

Rumjantseva

Hoffmeister

2010

Transfusion and Apheresis Science

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Storage at room temperature is limited to 5 days because of the risk of bacterial growth and loss of platelet functionality. Platelet refrigeration remains impossible, because once chilled, platelets are rapidly removed from circulation. Chilling platelets (<4 h) clusters glycoprotein (GP) Ibα receptors, and β2 integrins on hepatic macrophages recognize clustered βGlcNAc residues leading to rapid clearance of acutely chilled platelets. Prolonged refrigeration increases the exposure of galactose residues such that, unexpectedly, hepatocytes remove platelets using their asialoglycoprotein receptors. Here we review current knowledge of the mechanisms of platelet removal, the existing knowledge of refrigerated platelet function, and methods to preserve platelet concentrates long-term for transfusion.

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“…Previous trials have investigated single‐donor PLT concentrates (SDPs) collected at concentrations greater than 3 × 10 6 PLTs per µL that were stored after the addition of PAS. Those studies have shown that in vitro PLT characteristics are mainly dependent on the type and quantity of the additive solution used, as well as on the remaining amount of plasma in the product 2,5‐8 . The effect of the time interval between collection of the hyperconcentrated PLT suspensions (HPSs) and the addition of PAS on PLTs’ storage characteristics, however, is unknown.…”

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confidence: 99%

Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets

Ringwald

Haager²,

Krex³

et al. 2006

Transfusion

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Storage of platelets in additive solutions: a multicentre study of the in vitro effects of potassium and magnesium

Cited by 81 publications

References 12 publications

Current Understanding of Allergic Transfusion Reactions: Incidence, Pathogenesis, Laboratory Tests, Prevention and Treatment

Current Understanding of Allergic Transfusion Reactions: Incidence, Pathogenesis, Laboratory Tests, Prevention and Treatment

Novel and unexpected clearance mechanisms for cold platelets

Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets

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