Storage and survival of red blood cells with elevated sodium levels

Wallas, Charles H.; Harris, Ave; Wetherall, Neal T.

doi:10.1046/j.1537-2995.1982.22583017459.x

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Indeed, approximately 25 percent of black blood donors have elevated RBC sodium (Na i ) level compared with white donors, probably due to an unknown genetic change. This elevation results in a significant increase in the mean Na i from black (9.00 ± 2.96 mmoles/L RBC) as compared to white blood donors (7.04 ± 1.48 mmoles/L RBC, p < 0.001) (Wallas et al, 1982). …”

Section: Variations In Donor Red Cell Propertiesmentioning

confidence: 99%

The involvement of cation leaks in the storage lesion of red blood cells

2014

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Stored blood components are a critical life-saving tool provided to patients by health services worldwide. Red cells may be stored for up to 42 days, allowing for efficient blood bank inventory management, but with prolonged storage comes an unwanted side-effect known as the “storage lesion”, which has been implicated in poorer patient outcomes. This lesion is comprised of a number of processes that are inter-dependent. Metabolic changes include a reduction in glycolysis and ATP production after the first week of storage. This leads to an accumulation of lactate and drop in pH. Longer term damage may be done by the consequent reduction in anti-oxidant enzymes, which contributes to protein and lipid oxidation via reactive oxygen species. The oxidative damage to the cytoskeleton and membrane is involved in increased vesiculation and loss of cation gradients across the membrane. The irreversible damage caused by extensive membrane loss via vesiculation alongside dehydration is likely to result in immediate splenic sequestration of these dense, spherocytic cells. Although often overlooked in the literature, the loss of the cation gradient in stored cells will be considered in more depth in this review as well as the possible effects it may have on other elements of the storage lesion. It has now become clear that blood donors can exhibit quite large variations in the properties of their red cells, including microvesicle production and the rate of cation leak. The implications for the quality of stored red cells from such donors is discussed.

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Section: Variations In Donor Red Cell Propertiesmentioning

confidence: 99%

The involvement of cation leaks in the storage lesion of red blood cells

2014

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Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?

et al. 2021

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Red blood cell (RBC) transfusion is one of the most common therapeutic procedures in modern medicine. Although frequently lifesaving, it often has deleterious side effects. RBC quality is one of the critical factors for transfusion efficacy and safety. The role of various factors in the cells' ability to maintain their functionality during storage is widely discussed in professional literature. Thus, the extra- and intracellular factors inducing an accelerated RBC aging need to be identified and therapeutically modified. Despite the extensively studied in vivo effect of chronic hyperglycemia on RBC hemodynamic and metabolic properties, as well as on their lifespan, only limited attention has been directed at the high sugar concentration in RBCs storage media, a possible cause of damage to red blood cells. This mini-review aims to compare the biophysical and biochemical changes observed in the red blood cells during cold storage and in patients with non-insulin-dependent diabetes mellitus (NIDDM). Given the well-described corresponding RBC alterations in NIDDM and during cold storage, we may regard the stored (especially long-stored) RBCs as "quasi-diabetic". Keeping in mind that these RBC modifications may be crucial for the initial steps of microvascular pathogenesis, suitable preventive care for the transfused patients should be considered. We hope that our hypothesis will stimulate targeted experimental research to establish a relationship between a high sugar concentration in a storage medium and a deterioration in cells' functional properties during storage.

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Storage and survival of red blood cells with elevated sodium levels

Cited by 2 publications

References 7 publications

The involvement of cation leaks in the storage lesion of red blood cells

The involvement of cation leaks in the storage lesion of red blood cells

Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?

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