Storage and Propulsion along the Large Intestine

Devroede, Ghislain

doi:10.1007/978-1-4757-0307-8_7

Colon 1983

DOI: 10.1007/978-1-4757-0307-8_7

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Storage and Propulsion along the Large Intestine

Ghislain Devroede

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Cited by 4 publications

References 134 publications

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Distension-stimulated propagated contractions in human colon

et al. 1994

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To investigate the mechanisms for elicitation of peristaltic activity in the human colon, we studied the effect of balloon distension of the transverse, descending, and sigmoid colon and the rectum. Fifteen healthy subjects were studied by means of a colonoscopically positioned probe carrying a 5-cm latex balloon. After positioning of the probe, stepwise distension was performed for each colonic segment (transverse, descending, sigmoid, rectum), and the onset of large (> 50 mm Hg) and small (< 50 mm Hg) propagated waves was observed. Analysis of the tracings showed: (1) In 8/15 subjects (53.3%), balloon distension elicited propagated contractions, but these contractions were qualitatively different from the spontaneously occurring high-amplitude propagated contractions previously found to occur in association with defecation. Therefore, intraluminal distension is probably not the cause of defecation-associated high-amplitude propagated contractions. (2) Pain reports were poorly correlated with propagated contractions elicited by balloon distension, suggesting that these contractions are not the cause of the pain produced by balloon distension. (3) The transverse colon shows lower pressures, fewer pain reports, and fewer large propagated contractions in response to balloon distension as compared to the descending and the sigmoid colon.

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Distension-stimulated propagated contractions in human colon

et al. 1994

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The rumen as a model of the microbiology of fibre digestion in the human intestine

Henderson

Demeyer

1989

Animal Feed Science and Technology

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Colonic capacitance and transit in man: modulation by luminal contents and drugs.

Kamath

Phillips

O’Connor

et al. 1990

Gut

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We have examined whether the human colon is able to adapt its capacity to receive fluid, specifically, whether the caecum and ascending colon ('right colon') exhibited any reservoir function. Healthy volunteers had the caecum intubated from above with a device that permitted intraluminal pressures to be recorded while fluids were instilled into the caecum.Perfusates contained 'Tc-DTPA (diethylenetriamine pentaacetic acid) and volumes of the right colon were determined by two plane scintigraphy using gamma cameras. Different individuals received caecal infusions of 154 mM NaCl (saline), an emulsion of oleic acid (with bile acids and lecithin) or a 100 mM solution of mixed short chain fatty acids. Each person was pretreated by intravenous saline (placebo), morphine sulphate (100 ,ug/kg) or naloxone (5.5 mg as a bolus, followed by 10 [tg/ kg/min). Volumes of the right colon were smallest during oleic acid infusion; morphine reversed the effect of luminal fat and allowed the colon to accommodate larger volumes. Transit from the right colon was more rapid for the emulsion of oleic acid than it was for saline or solutions of mixed short chain fatty acids. We conclude that the right colon may act as a reservoir and that this finction can be modified by the nature of the contents and by pharmacological agents.

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Storage and Propulsion along the Large Intestine

Cited by 4 publications

References 134 publications

Distension-stimulated propagated contractions in human colon

Distension-stimulated propagated contractions in human colon

The rumen as a model of the microbiology of fibre digestion in the human intestine

Colonic capacitance and transit in man: modulation by luminal contents and drugs.

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