Storage and elimination of titanium, aluminum, and vanadium salts, <i>in vivo</i>

Merritt, Katharine; Margevicius, R. W.; Brown, Stanley A.

doi:10.1002/jbm.820261109

Cited by 46 publications

(20 citation statements)

References 16 publications

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“…These findings are consistent with the findings by Cruz et al (1995) demonstrating that daily administration of 500 [ig of orthovanadate for 10 days inhibited MDAY-D2 tumour growth in mice by over 85%. Interestingly, the in vitro drug-release profiles showed that paste containing 25% and 30% BMOV released approximately 500 [ig of BMOV per day, which is a similar daily dosage to that used previously (Cruz et al, 1995 Following intraperitoneal injections, the plasma levels of vanadate increase to very high levels almost immediately followed by a rapid clearance into the urine, as has been described previously (Harris et al, 1984;Merritt et al, 1992). Subcutaneous administration is likely to lead to high plasma concentrations within the first few hours of treatment followed by a rapid clearance.…”

Section: Discussionsupporting

confidence: 76%

A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

Jackson

Wang²,

Tf³

et al. 1997

Br J Cancer

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Summary Using vanadyl sulphate, sodium orthovanadate or bis(maltolato)oxovanadium (BMOV), Cruz TF, Morgan A, Min W (1995, Mol Cell Biochem 153: 161-166) have recently demonstrated the antineoplastic effects of vanadium in mice. In this study, the antineoplastic effects of BMOV against human tumour cell lines was confirmed, and this effect was shown to depend on the prolonged exposure of the cells to the drug. We have investigated a polymeric drug delivery system for the sustained delivery of BMOV as an antineoplastic agent in mice. The objective was to design and evaluate an injectable polymer-BMOV paste that would act as a drug implant for the slow but sustained release of BMOV in the mice. In vitro studies showed that the biodegradable polymer poly (Ghlr epsilon E-caprolactone) (PCL) released BMOV in a sustained manner with rates of drug release increasing with increased loading of the drug in the polymer. In vivo studies showed that PCL-BMOV paste implants produced a concentration-dependent inhibition of MDAY-D2 tumour growth via systemic drug delivery. Further in vivo studies showed that 5% BMOV-loaded PCL (containing 20% methoxypolyethylene glycol) was effective in preventing tumour regrowth of resected RIF tumour masses in mice when the PCL-BMOV paste was applied to the resected site for localized drug delivery. The results confirm the potential of vanadium as an antineoplastic agent and show that the injectable PCL-BMOV formulation releases a chemotheraputic dose of vanadium for the systemic treatment of whole tumours as well as the localized treatment of resected RIF tumours.

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Section: Discussionsupporting

confidence: 76%

A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

Jackson

Wang²,

Tf³

et al. 1997

Br J Cancer

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“…Ni elimination occurs through urine and bile (Ishihara et al, 1991;Srivastava et al, 1990). The greatly elevated excretion of Ti through bile may be attributed to its accumulation in the liver, and according to Merritt and coworkers, Ti is not excreted through the urine (Merritt, 1992).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Alterations of Toxic and Nonessential Elements by the Treatment of Sempervivum tectorum Extract in a Hyperlipidemic Rat Model

et al. 2004

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A hyperlipidemic rat model was used to examine the therapeutic effect of Sempervivum tectorum plant extract on the metabolic alterations of Al, As, B, Ba, Cd, Hg, Ni, Pb, and Ti in the liver and bile. Hyperlipidemia was produced by lipogenic diet and alcohol and verified by morphological investigation of the liver with the aid of light and an electron microscope. Element concentration in the liver and bile were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration values in the liver higher than the detection limit (Al, Ba, Ni, Ti) were unambiguous. Significant differences were found for the four groups at p < 0.05 level (ANOVA). A significant difference was observed between Al and B concentration in the bile fluids of the 4 groups ( p < 0.05). The excretion of Al and Ti into the bile fluid increased significantly ( p < 0.05). Following the administration of S. tectorum extract to rats with hyperlipidemia, the excretion of Al, B and Ba increased, whereas the excretion of Ti decreased significantly ( p < 0.05). The favorable action of the extract (protecting the liver in hyperlipidemic rats) was verified by morphological studies, and its detoxicating property was shown by the elimination of Al, Ba, Ni, and Ti from the liver.

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“…[6][7][8] The contribution of elements released from dental restorations to the systemic body burden remains controversial, but the retention of artificially injected elements in various tissues demonstrates that released elements may accumulate in tissues over time. [9][10][11] The use of Ni-based alloys for dental restorations is a continuing concern because these alloys release levels of Ni which can approach daily dietary intake. 1 The corrosion of Ni-based dental alloys has been well documented in vitro [12][13][14] and in vivo, [15][16][17] particularly if the pH of the corroding solution falls below 6.0, 18 a common condition in the mouth.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ni ions on expression of intercellular adhesion molecule 1 by endothelial cells

Wataha

Sun

Hanks

et al. 1997

J. Biomed. Mater. Res.

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Previous studies have shown that Ni-based alloys implanted into soft tissues cause an infiltration of inflammatory cells around the implant. This phenomenon is potentially important to dental alloys which are adjacent to oral tissues. To help define the mechanisms by which Ni causes an infiltration of inflammatory cells, we exposed endothelial cells in vitro to Ni ions and measured the expression of intercellular adhesion molecule 1 (ICAM-1). ICAM-1 is known to be involved in the recruitment of inflammatory cells from the bloodstream. We also exposed macrophages to Ni ions to test the hypothesis that Ni might alter cytokine secretion and subsequently cause expression of ICAM-1 on endothelial cells. The results showed that Ni ions could promote the expression of ICAM-1 on endothelial cells, but only at concentrations which were high enough (850 mumol/L for 24 h) to suppress cell metabolic activity. Although we had previous evidence that Ni could cause macrophages to secrete cytokines such as interleukin 1 beta, Ni-exposed macrophage supernatants did not induce expression of ICAM-1 on endothelial cells at concentrations subtoxic to the macrophages (85 mumol/L). At subtoxic concentrations, Ni ions were able to suppress ICAM-1 expression on endothelial cells which were stimulated with lipopolysaccharide. Thus, Ni ions either promoted or suppressed the expression of ICAM-1 depending on their concentration. This dual action of Ni ions may be important in vivo where a gradient of concentrations of released ions is likely to exist around the implanted biomaterial. Further studies are necessary to determine the effect of time of exposure and the molecular mechanisms of increased ICAM-1 expression.

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Storage and elimination of titanium, aluminum, and vanadium salts, in vivo

Cited by 46 publications

References 16 publications

A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

Metabolic Alterations of Toxic and Nonessential Elements by the Treatment of Sempervivum tectorum Extract in a Hyperlipidemic Rat Model

Effect of Ni ions on expression of intercellular adhesion molecule 1 by endothelial cells

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