Stopping power of liquid water for carbon ions in the energy range between 1 MeV and 6 MeV

Rahm, Johannes; Baek, Woon Yong; Rabus, Hans; Hofsäss, H

doi:10.1088/0031-9155/59/14/3683

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…The S e (E ) dependence calculated using Eq. (2) (thick solid line) gives the best agreement with the experimental data for carbon ions [62] in terms of both the position of the Bragg peak and its magnitude. Reportedly, there is no experimentally measured S e (E ) dependence for ions heavier than carbon, and the comparison can only be made with the results of other calculations or Monte Carlo simulations.…”

Section: Different Projectile Ionssupporting

confidence: 53%

“…The results are compared with the values compiled in the ICRU73 report [59] (open symbols) and the results of Monte Carlo simulations [60] performed using the Geant4-DNA software package [61] (closed symbols). (b) Comparison of the calculated LET for carbon ions (thick solid line) with experimental measurements [62] (open triangles) and other theoretical calculations performed using the widely-used SRIM [63] (thin solid line) and CasP [64] (dashed line) codes. kinetic energy.…”

Section: Fig 2 (A)mentioning

confidence: 99%

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Lethal DNA damage caused by ion-induced shock waves in cells

et al. 2021

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The elucidation of fundamental mechanisms underlying ion-induced radiation damage of biological systems is crucial for advancing radiotherapy with ion beams and for radiation protection in space. The study of ion-induced biodamage using the phenomenon-based multiscale approach (MSA) to the physics of radiation damage with ions has led to the prediction of nanoscale shock waves created by ions in a biological medium at the high linear energy transfer (LET). The high-LET regime corresponds to the keV and higher-energy losses by ions per nanometer, which is typical for ions heavier than carbon at the Bragg peak region in biological media. This paper reveals that the thermomechanical stress of the DNA molecule caused by the ion-induced shock wave becomes the dominant mechanism of complex DNA damage at the high-LET ion irradiation. Damage of the DNA molecule in water caused by a projectile-ion-induced shock wave is studied by means of reactive molecular dynamics simulations. Five projectile ions (carbon, oxygen, silicon, argon, and iron) at the Bragg peak energies are considered. For the chosen segment of the DNA molecule and the collision geometry, the number of DNA strand breaks is evaluated for each projectile ion as a function of the bond dissociation energy and the distance from the ion's path to the DNA strands. Simulations reveal that argon and especially iron ions induce the breakage of multiple bonds in a DNA double convolution containing 20 DNA base pairs. The DNA damage produced in segments of such size leads to complex irreparable lesions in a cell. This makes the shock-wave-induced thermomechanical stress the dominant mechanism of complex DNA damage at the high-LET ion irradiation. A detailed theory for evaluating the DNA damage caused by ions at high-LET is formulated and integrated into the MSA formalism. The theoretical analysis reveals that a single ion hitting a cell nucleus at high-LET is sufficient to produce highly complex, lethal damages to a cell by the shock-waveinduced thermomechanical stress. Accounting for the shock-wave-induced thermomechanical mechanism of DNA damage provides an explanation for the "overkill" effect observed experimentally in the dependence of cell survival probabilities on the radiation dose delivered with iron ions. This important observation provides strong experimental evidence of the ion-induced shock-wave effect and the related mechanism of radiation damage in cells.

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Section: Different Projectile Ionssupporting

confidence: 53%

Section: Fig 2 (A)mentioning

confidence: 99%

Lethal DNA damage caused by ion-induced shock waves in cells

et al. 2021

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“…The S e (E) dependence calculated using Eq. (2) (thick solid line) gives the best agreement with the experimental data for carbon ions [54] in terms of both the position of the Bragg peak and its magnitude. Reportedly, there is no experimentally measured S e (E) dependence for ions heavier than carbon, and the comparison can only be made with the results of other calculations or Monte Carlo simulations.…”

Section: Different Projectile Ionssupporting

confidence: 53%

“…The results are compared with the values compiled in the ICRU73 report [52] (open symbols) and with the results of Monte Carlo simulations performed using Geant4-DNA software package [53] (closed symbols). B: Comparison of the calculated LET for carbon ions (thick solid line) with experimental measurements [54] (open triangles) and other theoretical calculations performed using the widely-used SRIM [55] (thin solid line) and CasP [56]…”

Section: Fig 2 Amentioning

confidence: 99%

Lethal DNA damages caused by ion-induced shock waves in cells

Friis,

Verkhovtsev,

Solov'yov

et al. 2021

Preprint

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“…At lower energies, the MELF-GOS method systematically gives larger stopping power values than those obtained by the LR-TDDFT ELF; the largest discrepancy is ∼3% and occurs around the maximum stopping power at carbon energies ∼220 keV/u. Recently, a sophisticated experiment to measure the stopping power of carbon ions in liquid water (whose results are depicted by red circles in Figure 3 b) has been performed [ 13 ] for energies in the range 1–6 MeV (around the maximum stopping power) using the inverted Doppler shift attenuation method with an improved experimental setup than in preliminary measurements [ 98 ]. These are the only experimental stopping power data available for carbon ions in liquid water around the maximum.…”

Section: Methodsmentioning

confidence: 99%

Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water

Vera

Taioli

Trevisanutto

et al. 2022

IJMS

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Energetic carbon ions are promising projectiles used for cancer radiotherapy. A thorough knowledge of how the energy of these ions is deposited in biological media (mainly composed of liquid water) is required. This can be attained by means of detailed computer simulations, both macroscopically (relevant for appropriately delivering the dose) and at the nanoscale (important for determining the inflicted radiobiological damage). The energy lost per unit path length (i.e., the so-called stopping power) of carbon ions is here theoretically calculated within the dielectric formalism from the excitation spectrum of liquid water obtained from two complementary approaches (one relying on an optical-data model and the other exclusively on ab initio calculations). In addition, the energy carried at the nanometre scale by the generated secondary electrons around the ion’s path is simulated by means of a detailed Monte Carlo code. For this purpose, we use the ion and electron cross sections calculated by means of state-of-the art approaches suited to take into account the condensed-phase nature of the liquid water target. As a result of these simulations, the radial dose around the ion’s path is obtained, as well as the distributions of clustered events in nanometric volumes similar to the dimensions of DNA convolutions, contributing to the biological damage for carbon ions in a wide energy range, covering from the plateau to the maximum of the Bragg peak.

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Stopping power of liquid water for carbon ions in the energy range between 1 MeV and 6 MeV

Cited by 6 publications

References 15 publications

Lethal DNA damage caused by ion-induced shock waves in cells

Lethal DNA damage caused by ion-induced shock waves in cells

Lethal DNA damages caused by ion-induced shock waves in cells

Energy Deposition around Swift Carbon-Ion Tracks in Liquid Water

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