Stones left unturned: Missed opportunities to diagnose primary hyperparathyroidism in patients with nephrolithiasis

Lui, Michael S.; Fisher, Jason C.; Underwood, Hunter J.; Patel, Kepal N.; Ogilvie, Jennifer B.

doi:10.1016/j.surg.2021.03.073

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…In this study, the patients with a history of genitourinary stones had an increased risk of mortality. Genitourinary stones are a common complication of PHPT that 15-60% of patients with PHPT experience at baseline [12,13]. In the general population, stones are often associated with risk factors of atherosclerosis, such as obesity, diabetes, hypertension, and dyslipidemia [14][15][16], leading to an increased risk of subclinical atherosclerosis [17].…”

Section: Discussionmentioning

confidence: 99%

Residual risks of comorbidities after parathyroidectomy in a nationwide cohort of patients with primary hyperparathyroidism

et al. 2022

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Purpose: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with increasing incidence, while epidemiologic data in Asian population has been lacking. Therefore, we aimed to identify the incidence, prognosis, and prognostic factors of PHPT patients who underwent parathyroidectomy in Korea.Methods: In this retrospective nationwide cohort, patients with PHPT were de ned as those with diagnostic codes of PHPT and procedural codes for parathyroidectomy, excluding chronic renal failure or secondary hyperparathyroidism based on National Health Insurance Services database in Korea in 2002-2018. Main primary outcomes were all-cause mortality, cardiovascular, and cerebrovascular events.Results: A total of 5,561 patients were diagnosed with PHPT and had parathyroidectomy. The mean age was 54.5 years, and 71.8% were women. The age-standardized incidence was 10.1/ 100,000 person-year in 2018, rising from 1.7/100,000 person-year in 2002. During a mean of 5.9 years, history of cardiovascular disease, mood disorder, and genitourinary stone had increased risks of mortality with hazard ratios (HRs) of 1.59 (95% con dence interval [

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