Stone formation in patients less than 20 years of age is associated with higher rates of stone recurrence: Results from the Registry for Stones of the Kidney and Ureter (ReSKU)

Li, Yang; Bayne, David; Wiener, Scott; Ahn, JoongHo; Stoller, Marshall L.; Chi, Thomas

doi:10.1016/j.jpurol.2020.03.014

Cited by 22 publications

(7 citation statements)

References 22 publications

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“…Former studies have failed to reach consensus on the possible contribution of patient’s sex to urinary stone recurrence, with most studies demonstrating male sex as a major contributor to recurrence, 18 , 19 while others propose female sex as a significant risk factor. 20 Our data failed to contribute to this scientific discourse and only suggested that patient’s sex appears to be unrelated to stone recurrence.…”

Section: Discussionmentioning

confidence: 62%

Predictors of Recurrent Urolithiasis in Iran: Findings from a Nationwide Study

Basiri,

Kashi,

Zahir

et al. 2024

Arch Iran Med

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Background: Prevention of urinary stone recurrence is the ultimate goal in urolithiasis patients. In this study, we aimed to investigate the national prevalence rate and possible determinants of increased urolithiasis recurrence risk in a nationwide study in Iran. Methods: All data regarding stone occurrence and recurrence episodes were extracted from the cross-sectional Iran National Stone Survey (INSS) study, and the possible determinants of recurrence were evaluated in the subset of 2913 patients who had a positive history of at least one episode of urolithiasis. Results: The national prevalence rate of recurrent urolithiasis was 2.6% (95% CI: 2.5, 2.8) in Iran. Moreover, the relative ratio of recurrent stone formers to all stone formers was 39.8% (95% CI: 38.0, 41.6). Our univariable truncated negative binomial regressions suggested that a positive history of urolithiasis in the patient’s father (prevalence ratio [PR] [95% CI]=1.83 [1.39, 2.41], P<0.001), mother (PR [95% CI]=1.92 [1.39, 2.66], P<0.001) or brother (PR [95% CI]=1.32 [1.03, 1.69], P=0.026); and residence in urban areas (PR [95% CI]=1.27 [1.04, 1.55], P=0.016) were significant predictors of repetitive recurrence episodes. However, when incorporated into a multivariable truncated negative binomial regression model, the only significant predictors of more frequent recurrence episodes were a positive history in father (PR [95% CI]=1.66 [1.24, 2.22], P<0.001) and mother (PR [95% CI]=1.68 [1.20, 2.36], P=0.002); and urban residence (PR [95% CI]=1.24 [1.01, 1.51], P=0.031). Conclusion: Our results indicate that a positive family history of urolithiasis in mother and father and residence in urban areas are the significant predictors of recurrence risk in urolithiasis patients in Iran.

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Section: Discussionmentioning

confidence: 62%

Predictors of Recurrent Urolithiasis in Iran: Findings from a Nationwide Study

Basiri,

Kashi,

Zahir

et al. 2024

Arch Iran Med

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“…8 Some studies in the pediatric population that have shown an increasing incidence of female nephrolithiasis over the last two decades. 9,10 It is important to note that the majority of recurrent stone formers were female. 11 In the present study, a positive family history of urolithiasis was found in 81 (39.7%) patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile, diagnosis and treatment of pediatric urolithiasis: a single center experience in Kazakhstan

Sagymbayeva

2023

Bangladesh J Med Sci

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Objective: The aim of our study to present the results of the clinical profile, diagnosis and treatment of children with urolithiasis in the Pediatric Urology Department of the Scientific center of Pediatria and Pediatric surgery in Almaty, Kazakhstan. Materials and methods: A retrospective data from pediatric patients with urolithiasis admitted from January 2015 to December 2021. The data was obtained from medical records and included those with diagnosis confirmed by imaging and laboratory test, as 24-hour urine exams corrected for creatinine, stone composition. Results: We reviewed 204 children with urolithiasis. The male‐to‐female ratio was 1.34:1. Congenital anomalies of the urinary tract were found in 40 patients (19.6%).Urolithiasis was more common in adolescent girls, whereas in boys the frequency of observation is higher between 11 and 17 years old (p = 0.006). Majority of the patients were from southern regions (51%) in our country. Renal colic, urinary tract infection and macroscopic hematuria were the most common clinical manifestations. Urinary tract infection was diagnosed in 185 patients (90.6%). The most frequent metabolic disorders were hypercalciuria, hyperoxaluria. In 35% of cases there was a metabolic disorder and appropriate therapy was prescribed. In the remaining cases, surgical treatment was used. Conclusion: In this study we presented the prevalence of urolithiasis in the pediatric population in different regions of our country. We identified a high prevalence of infective stone as an etiological factor of pediatric urolithiasis. Clinical symptoms depending on the age and location of the stones. Bangladesh Journal of Medical Science Vol. 22 No. 02 April’23 Page : 297-304

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“…Its significance stems from the high volume of cases, costly and painful renal colic episodes, and the requirements for updated healthcare facilities. One important aspect of urinary stones is the high rate of recurrence in both the pediatric and adult populations [1,2]. The recurrence rates were 11, 20, 31, and 39% at 2, 5, 10, and 15 years, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

Metabolic stone workup abnormalities are not as important as stone culture in patients with recurrent stones undergoing percutaneous nephrolithotomy

et al. 2023

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To investigate the association between metabolic urinary abnormalities and urinary tract infection (UTI) and the stone recurrence status in patients undergoing percutaneous nephrolithotomy (PCNL). A prospective evaluation was performed for patients who underwent PCNL between November 2019 and November 2021 and met the inclusion criteria. Patients with previous stone interventions were classified as recurrent stone formers. Before PCNL, a 24 h metabolic stone workup and midstream urine culture (MSU-C) were done. Renal pelvis (RP-C) and stones (S-C) cultures were collected during the procedure. The association between the metabolic workup and UTI results with stone recurrence was evaluated using univariate and multivariate analyses. The study included 210 patients. UTI factors that showed significant association with stone recurrence included positive S-C [51 (60.7%) vs 23 (18.2%), p < 0.001], positive MSU-C [37 (44.1%) vs 30 (23.8%), p = 0.002], and positive RP-C [17 (20.2%) vs 12 (9.5%), p = 0.03]. Other factors were mean ± SD GFR (ml/min) (65 ± 13.1 vs 59.5 ± 13.1, p = 0.003), calcium-containing stones [47 (55.9%) vs 48 (38.1%), p = 0.01], median (IQR) urinary citrate levels (mg/day) [333 (123–512.5) vs 221.5 (120.3–412), p = 0.04], and mean ± SD urinary pH (6.1 ± 1 vs 5.6 ± 0.7, p < 0.001). On multivariate analysis, only positive S-C was the significant predictor of stone recurrence (odds ratio: 9.9, 95% confidence interval [CI] (3.8–28.6), p < 0.001). Positive S-C, and not metabolic abnormalities, was the only independent factor associated with stone recurrence. A focus on preventing UTI might prevent further stone recurrence.

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Stone formation in patients less than 20 years of age is associated with higher rates of stone recurrence: Results from the Registry for Stones of the Kidney and Ureter (ReSKU)

Cited by 22 publications

References 22 publications

Predictors of Recurrent Urolithiasis in Iran: Findings from a Nationwide Study

Predictors of Recurrent Urolithiasis in Iran: Findings from a Nationwide Study

Clinical profile, diagnosis and treatment of pediatric urolithiasis: a single center experience in Kazakhstan

Metabolic stone workup abnormalities are not as important as stone culture in patients with recurrent stones undergoing percutaneous nephrolithotomy

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