Stomach cancer burden in Central and South America

Sierra, Mónica S.; Cueva, Patricia; Bravo, Luis Eduardo; Forman, David

doi:10.1016/j.canep.2016.03.008

Cited by 64 publications

(61 citation statements)

References 64 publications

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“…Our results are in accordance to recent epidemiological studies carried out in the US, where Hispanic patients are more frequently diagnosed with gastric cancer at younger ages than any other ethnic group (21% vs. 7-16%) (3,4). This percentage of young patients with stomach cancer is also very similar with the rate reported by Sierra et al for patients living in Central and South America (12). As described by other authors (13), we found that patients at younger age were more likely to have malignant tumours with diffuse histology (according to Lauren's classification) J Gastrointest Oncol 2018;9(1):64-72 jgo.amegroups.com and poor or undifferentiated tumours than older patients.…”

Section: Discussionsupporting

confidence: 82%

Predictors of overall survival after surgery in gastric cancer patients from a Latin-American country

Cordero-García¹,

Ramos-Esquivel²,

Alpízar‐Alpízar³

2018

J. Gastrointest. Oncol.

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Section: Discussionsupporting

confidence: 82%

Predictors of overall survival after surgery in gastric cancer patients from a Latin-American country

Cordero-García¹,

Ramos-Esquivel²,

Alpízar‐Alpízar³

2018

J. Gastrointest. Oncol.

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“…In males, the highest mortality rates were observed in Chile and Costa Rica (20.1–24.6) and the lowest rates were in Suriname, Cuba and Paraguay (5.0–7.1). In females, the highest rates were seen in Guatemala (17.1) followed by Ecuador and Peru (10.5–11.2) and the lowest rates were in Paraguay, Argentina, Cuba and Suriname (2.9–3.9) [75]. Colorectal cancer was among the five most common cancers diagnosed in males and females (except in El Salvador, where it ranked seventh and ninth, respectively) and one of the eight most frequent causes of cancer deaths in Latin America.…”

Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

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“…GC is associated with high morbidity and mortality burden, especially in low and middle income countries [6]. The highest incidences of GC have been observed in East Asia, Eastern Europe, and South America, whereas the lowest rates occur in North America, South Asia, North and East Africa, and Australia [1,2].…”

Section: Introductionmentioning

confidence: 99%

Unequal burden of mortality from gastric cancer in Brazil and its regions, 2000–2015

Braga¹,

Ramos

Neto³

et al. 2019

Gastric Cancer

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Background Gastric cancer (GC) is an important cause of morbidity and mortality worldwide. However, population-based data on GC mortality dynamics in low and middle income countries are scarce. Methods We analyzed GC mortality in Brazil based on all GC-related deaths registered 2000-2015.Results A total of 17,374,134 deaths were recorded, with GC identified in 214,808 (1.24%) cases-203,941 (94.9%) as underlying cause, and 10,867 (5.1%) as associated cause of death. Adjusted rates for age and sex was 6.85 deaths/100,000 inhabitants [95% confidence interval (CI) 6.73-6.97]. The highest mortality rates were found in males [10.00; rate ratio (RR) 1.85; 95% CI 1.78-1.91; p < 0.0001] and patients ≥ 45 years of age (24.98; RR 3.79; 95% CI 3.55-4.05; p < 0.0001). The South (7.56; RR 1.62; 95% CI 1.50-1.76; p < 0.0001) and Southeast (7.36; RR 1.59; 95% CI 1.48-1.71; p < 0.0001) regions had the highest regional rates. Spatial and spatiotemporal high-risk mortality areas in 2004-2007 were located mainly in the South, Southeast, and Central-West regions. After 2008, the Northeast region became a high-risk area, especially Ceará State. Conclusion GC remains a significant public health problem with high mortality burden and unequal distribution in Brazilian states. The new patterns in poorer regions and the high risk in some specific populations show a clear process of epidemiological transition over time. There is a need to strengthen nationwide epidemiological monitoring, surveillance, prevention, and control for GC in the country.

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Stomach cancer burden in Central and South America

Abstract: The variation in rates may reflect differences in the prevalence of Helicobacter pylori infection and other risk factors. High mortality may additionally reflect deficiencies in healthcare access. The high proportion of unspecified cases calls for improving cancer registration processes.

Cited by 64 publications

References 64 publications

Predictors of overall survival after surgery in gastric cancer patients from a Latin-American country

Predictors of overall survival after surgery in gastric cancer patients from a Latin-American country

State of Art of Cancer Pharmacogenomics in Latin American Populations

Unequal burden of mortality from gastric cancer in Brazil and its regions, 2000–2015

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