2023
DOI: 10.1111/imr.13250
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Stocking the toolbox—Using preclinical models to understand the development and treatment of immune checkpoint inhibitor‐induced immune‐related adverse events

Morgan L. Cina,
Jessica Venegas,
Arabella Young

Abstract: SummaryCancer patients treated with immune checkpoint inhibitors (ICIs) are susceptible to a broad and variable array of immune‐related adverse events (irAEs). With increasing clinical use of ICIs, defining the mechanism for irAE development is more critical than ever. However, it currently remains challenging to predict when these irAEs occur and which organ may be affected, and for many of the more severe irAEs, inaccessibility to the tissue site hampers mechanistic insight. This lack of understanding of irA… Show more

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Cited by 3 publications
(2 citation statements)
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References 149 publications
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“…For the last manuscript of this section, Morgan Cina, Jessica Venegas, and Arabella Young put together a very comprehensive review on the preclinical models available that capture some aspects of the irAE etiology across different organ systems. These can be used to study the biological underpinnings of irAEs, along with their relationship to anti‐tumor immune responses 55 . They examine the contexts for which these models are most useful, how they could be improved, as well as the advantages and disadvantages of different model systems.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…For the last manuscript of this section, Morgan Cina, Jessica Venegas, and Arabella Young put together a very comprehensive review on the preclinical models available that capture some aspects of the irAE etiology across different organ systems. These can be used to study the biological underpinnings of irAEs, along with their relationship to anti‐tumor immune responses 55 . They examine the contexts for which these models are most useful, how they could be improved, as well as the advantages and disadvantages of different model systems.…”
Section: Introductionmentioning
confidence: 99%
“…These can be used to study the biological underpinnings of irAEs, along with their relationship to anti-tumor immune responses. 55 The ability to predict the occurrence of specific irAEs to ICI will be a critical step towards the development of prophylactic therapies and could prove valuable in making informed decisions regarding tailoring cancer treatment options for each patient.…”
mentioning
confidence: 99%