Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones
M.G. Hirsch,
Soumitra Pal,
Farid Rashidi Mehrabadi
et al.
Abstract:Cancer progression is an evolutionary process driven by the selection of cells adapted to gain growth advantage. We present the first formal study on the adaptation of gene expression in subclonal evolution. We model evolutionary changes in gene expression as stochastic Ornstein–Uhlenbeck processes, jointly leveraging the evolutionary history of subclones and single–cell expression data. Applying our model to sublines derived from single cells of a mouse melanoma revealed that sublines with distinct phenotypes… Show more
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