Existing wireless networks provide dynamically varying resources with only limited support for the Quality of Service required by the bandwidth-intense, loss-tolerant, and delay-sensitive multimedia applications. This variability of resources does not significantly impact data applications (e.g., file transfers), but has considerable consequences for multimedia applications and often leads to unsatisfactory user experience. Recently, the research focus has been to adapt existing algorithms and protocols at the lower layers of the network stack to better support multimedia transmission applications, and conversely, to modify application layer solutions to cope with the varying wireless networks resources. In this paper, we show that significant improvements in wireless multimedia performance can be obtained by deploying a joint application-layer packetization and MAC-layer retransmission strategy. First, we show that packet-size optimizations solely determined at the MAC-layer result in a sub-optimal performance in terms of the multimedia quality. Subsequently, we propose cross-layer strategies that optimize the packetization, prioritization and retransmission strategies based on content characteristics, channel conditions, and the specific features of the deployed video coder. Finally, we investigate the use of content based distortion models for the video, to reduce the complexity of our proposed optimization. 1. Introduction Wireless networks provide only limited support for the Quality of Service (QoS) required by delay-sensitive and high-bandwidth multimedia applications as they provide dynamically varying resources in terms of available bandwidth, due to multi-path fading, co-channel interference, and noise disturbances. A variety of application-layer solutions have been proposed to cope with these challenges. These include rate adaptation, (rate-distortion optimized) scheduling, error resilience techniques, error concealment mechanisms and joint source-channel coding. An excellent review of application-layer research in wireless multimedia streaming is provided in [1]. Cross-layer design for wireless multimedia transmission has also been investigated (e.g. [7][11][15]) and the results indicate that a significant gain in performance can be obtained. It is however important to note that existing cross-layer solutions often overlook the important issue of packetization and its relationship to other protection strategies at various layers as well as its impact on the ratedistortion (R-D) performance at the application-layer. In this paper, we focus on developing content-based flexible and adaptive packetization strategies for scalable multimedia streams and corresponding Medium Access Control (MAC) retransmission strategies to enable optimal rate-distortion-resilience tradeoffs for wireless multimedia streaming. We develop these joint packetization-retransmission schemes using a crosslayer optimization approach, where the application layer collaborates with the MAC layer to jointly determine the optimal packet ...