2015
DOI: 10.1073/pnas.1510133112
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Stochastic electrotransport selectively enhances the transport of highly electromobile molecules

Abstract: Nondestructive chemical processing of porous samples such as fixed biological tissues typically relies on molecular diffusion. Diffusion into a porous structure is a slow process that significantly delays completion of chemical processing. Here, we present a novel electrokinetic method termed stochastic electrotransport for rapid nondestructive processing of porous samples. This method uses a rotational electric field to selectively disperse highly electromobile molecules throughout a porous sample without dis… Show more

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Cited by 209 publications
(249 citation statements)
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References 44 publications
(72 reference statements)
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“…15 However, strong electric field or high temperatures can damage tissue-gel hybrids on both a structural and molecular level. Stochastic implementations of electrophoresis 16 and novel tissue-hybrid recipes 17 improve sample stability while keeping lipid removal time quite short (few days). Continuous perfusion of the sample with SDS is another approach to improve clearing speed.…”
Section: Tissue Transformationmentioning
confidence: 99%
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“…15 However, strong electric field or high temperatures can damage tissue-gel hybrids on both a structural and molecular level. Stochastic implementations of electrophoresis 16 and novel tissue-hybrid recipes 17 improve sample stability while keeping lipid removal time quite short (few days). Continuous perfusion of the sample with SDS is another approach to improve clearing speed.…”
Section: Tissue Transformationmentioning
confidence: 99%
“…Recently, a speed-up of the clearing process has been achieved using stochastic electrotransport of lipids. 16 The use of electrophoresis, either "standard" or stochastic, introduces great technical complexity, unless a commercial system is used. Passive methods, relying on spontaneous diffusion of lipids, have been described.…”
Section: Endogenous Fluorescencementioning
confidence: 99%
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