Stochastic Acquisition of Qa1 Receptors During the Development of Fetal NK Cells In Vitro Accounts in Part But Not in Whole for the Ability of These Cells to Distinguish Between Class I-Sufficient and Class I-Deficient Targets
Abstract:Fetal mouse NK cells are grossly deficient in the expression of Ly49 molecules yet show a limited ability to distinguish between wild-type and MHC class I-deficient target cells. In this paper we report that during their development in vitro from immature thymic progenitors, a proportion of C57BL/6 fetal NK cells acquires receptors for a soluble form of the nonclassical class I molecule Qa1b associated with the Qdm peptide, but not for soluble forms of the classical class I molecules Kb and Db. The acquisition… Show more
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