STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
Zhen-Zhen Liu,
Cheng-Kai Zhou,
Xiao-Qi Lin
et al.
Abstract:Clostridium perfringens (C. perfringens) infection is recognized as one of the most challenging issues threatening food safety and perplexing agricultural development. To date, the molecular mechanisms of the interactions between C. perfringens and the host remain poorly understood. Here, we show that stimulator of interferon genes (STING)-dependent trained immunity protected against C. perfringens infection through mTOR signaling. Heat-killed Candida albicans (HKCA) training elicited elevated TNF-α and IL-6 p… Show more
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