Stimulus specificity of concurrent recovery in the rabbit nictitating membrane response

Weidemann, Gabrielle; Kehoe, E. James

doi:10.3758/bf03192863

Cited by 15 publications

(22 citation statements)

References 43 publications

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“…It may be instructive to compare our results with Kehoe and colleagues’ demonstrations of concurrent recovery in rabbit eyeblink conditioning (Macrae & Kehoe, 1999, Weidemann & Kehoe, 2003, 2004, 2005). As described previously, concurrent recovery refers to the recovery of responding to an extinguished CS after pairings of a new CS with the US.…”

Section: Discussionsupporting

confidence: 54%

Spontaneous recovery but not reinstatement of the extinguished conditioned eyeblink response in the rat.

Thanellou¹,

Green²

2011

Behavioral Neuroscience

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Reinstatement, the return of an extinguished conditioned response (CR) after reexposure to the unconditioned stimulus (US), and spontaneous recovery, the return of an extinguished CR with the passage of time, are two of four well-established phenomena which demonstrate that extinction does not erase the conditioned stimulus (CS)-US association. However, reinstatement of extinguished eyeblink CRs has never been demonstrated and spontaneous recovery of extinguished eyeblink CRs has not been systematically demonstrated in rodent eyeblink conditioning. In Experiment 1, US reexposure was administered 24 hours prior to a reinstatement test. In Experiment 2, US reexposure was administered 5 min prior to a reinstatement test. In Experiment 3, a long, discrete cue (a houselight), present in all phases of training and testing, served as a context within which each trial occurred to maximize context processing, which in other preparations has been shown to be required for reinstatement. In Experiment 4, an additional group was included that received footshock exposure, rather than US reexposure, between extinction and test, and contextual freezing was measured prior to test. Spontaneous recovery was robust in Experiments 3 and 4. In Experiment 4, context freezing was strong in a group given footshock exposure but not in a group given eyeshock US reexposure. There was no reinstatement observed in any experiment. With stimulus conditions that produce eyeblink conditioning and research designs that produce reinstatement in other forms of classical conditioning, we observed spontaneous recovery but not reinstatement of extinguished eyeblink CRs. This suggests that reinstatement, but not spontaneous recovery, is a preparation- or substrate-dependent phenomenon.

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Section: Discussionsupporting

confidence: 54%

Spontaneous recovery but not reinstatement of the extinguished conditioned eyeblink response in the rat.

Thanellou¹,

Green²

2011

Behavioral Neuroscience

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“…The present experiments avoided this problem by conducting summation tests with different modality stimuli. Importantly, previous experiments have reported little immediate cross-modal generalization in eyeblink in rats and NM conditioning in rabbits (Campolattaro & Freeman, 2006;Kehoe, 1988;Kehoe, Morrow, & Holt, 1984;Schreurs & Kehoe, 1987;Weidemann & Kehoe, 2005). The summation tests used in the present experiments were, therefore, more suitable for comparing Pavlovian conditioning inhibition and differential inhibition.…”

Section: Discussionmentioning

confidence: 78%

Changes in inhibition during differential eyeblink conditioning with increased training

Campolattaro

Schnitker

Freeman

2008

Learning & Behavior

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“…Such changes are apparent, but have not been systematically analyzed, in previously published eyelid conditioning studies in rat [Stanton et al, 1992 (Figs. 2, 3, and 5)] and rabbit [Weidemann and Kehoe, 2005 (Fig. 3); Kehoe et al, 2004 (Figs.…”

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confidence: 99%

A Decrementing Form of Plasticity Apparent in Cerebellar Learning

Ohyama¹,

Voicu²,

Kalmbach³

et al. 2010

J. Neurosci.

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Long-term synaptic plasticity is believed to underlie the capacity for learning and memory. In the cerebellum, for example, long-term plasticity contributes to eyelid conditioning and to learning in eye movement systems. We report evidence for a decrementing form of cerebellar plasticity as revealed by the behavioral properties of eyelid conditioning in the rabbit. We find that conditioned eyelid responses exhibit within-session changes that recover by the next day. These changes, which increase with the interstimulus interval, involve decreases in conditioned response magnitude and likelihood as well as increases in latency to onset. Within-subject comparisons show that these changes differ in magnitude depending on the type of training, arguing against motor fatigue or changes in motor pathways downstream of the cerebellum. These phenomena are also observed when stimulation of mossy fibers substitutes for the conditioned stimulus, suggesting that changes take place within the cerebellum or in downstream efferent pathways. Together, these observations suggest a plasticity mechanism in the cerebellum that is induced during training sessions and fades within 23 h. To formalize this hypothesis more specifically, we show that incorporating a short-lasting potentiation at the granule cell to Purkinje cell synapses in a computer simulation of the cerebellum reproduces these behavioral effects. We propose the working hypothesis that the presynaptic form of long-term potentiation observed at these synapses is reversed by time rather than by a corresponding long-term depression. These results demonstrate the utility of eyelid conditioning as a means to identify and characterize the rules that govern input to output transformations in the cerebellum.

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Stimulus specificity of concurrent recovery in the rabbit nictitating membrane response

Cited by 15 publications

References 43 publications

Spontaneous recovery but not reinstatement of the extinguished conditioned eyeblink response in the rat.

Spontaneous recovery but not reinstatement of the extinguished conditioned eyeblink response in the rat.

Changes in inhibition during differential eyeblink conditioning with increased training

A Decrementing Form of Plasticity Apparent in Cerebellar Learning

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