Stimulus-Specific Adaptation Beyond Pure Tones

Nelken, Israel; Yaron, Amit; Polterovich, Ana; Hershenhoren, Itai

doi:10.1007/978-1-4614-1590-9_45

Cited by 28 publications

(22 citation statements)

References 14 publications

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“…It is important to note that only one of the three contributing mechanisms of adaptation, namely depletion of neurotransmitter vesicles is in line with the interpretation of repetition effects according to the passive “refractoriness” model. Furthermore, SSA has more complex properties than is usually assumed from neural “refractoriness” in human electrophysiology (Nelken, 2012; Nelken et al, 2013). However, it is relatively unknown whether mechanisms underlying the repetition-related amplitude reduction and the increased response to “unpredicted” events interact.…”

Section: Introduction—what Is Visual Mmn and What Is It Good For?mentioning

confidence: 99%

Visual mismatch negativity: a predictive coding view

Stefanics

Kremláček

Czigler

2014

Front. Hum. Neurosci.

281

300

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An increasing number of studies investigate the visual mismatch negativity (vMMN) or use the vMMN as a tool to probe various aspects of human cognition. This paper reviews the theoretical underpinnings of vMMN in the light of methodological considerations and provides recommendations for measuring and interpreting the vMMN. The following key issues are discussed from the experimentalist's point of view in a predictive coding framework: (1) experimental protocols and procedures to control “refractoriness” effects; (2) methods to control attention; (3) vMMN and veridical perception.

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Section: Introduction—what Is Visual Mmn and What Is It Good For?mentioning

confidence: 99%

Visual mismatch negativity: a predictive coding view

Stefanics

Kremláček

Czigler

2014

Front. Hum. Neurosci.

281

300

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“…Although MMN is perhaps the best characterized pre-attentive mechanism for deviance detection that manifests about 100–200 ms after stimulus presentation, it is not the only mechanism for automatic change detection (1, 14). It is now known that there is neural activity in anatomical structures along the sensory processing hierarchy involved in change detection, some apparent as early as 30 ms after stimulus presentation (15). …”

Section: Introductionmentioning

confidence: 99%

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

et al. 2014

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Schizophrenia patients exhibit a decreased ability to detect change in their auditory environment as measured by auditory event-related potentials (ERP) such as mismatch negativity. This deficit has been linked to abnormal NMDA neurotransmission since, among other observations, non-selective channel blockers of NMDA reliably diminish automatic deviance detection in human subjects as well as in animal models. Recent molecular and functional evidence links NR2B receptor subtype to aberrant NMDA transmission in schizophrenia. However, it is unknown if NR2B receptors participate in pre-attentive deviance detection. We recorded ERP from the vertex of freely behaving rats in response to frequency mismatch protocols. We saw a robust increase in N1 response to deviants compared to standard as well as control stimuli indicating true deviance detection. Moreover, the increased negativity was highly sensitive to deviant probability. Next, we tested the effect of a non-selective NMDA channel blocker (ketamine, 30 mg/kg) and a highly selective NR2B antagonist, CP-101,606 (10 or 30 mg/kg) on deviance detection. Ketamine attenuated deviance mainly by increasing the amplitude of the standard ERP. Amplitude and/or latency of several ERP components were also markedly affected. In contrast, CP-101,606 robustly and dose-dependently inhibited the deviant’s N1 amplitude, and as a consequence, completely abolished deviance detection. No other ERPs or components were affected. Thus, we report first evidence that NR2B receptors robustly participate in processes of automatic deviance detection in a rodent model. Lastly, our model demonstrates a path forward to test specific pharmacological hypotheses using translational endpoints relevant to aberrant sensory processing in schizophrenia.

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“…Modulation of MMN23242526 and SSA272829 in response to changes in pure tone frequency, syllables, and other complex stimuli are reported in the auditory cortex, as well as in subcortical structures in the auditory pathway (MMN30 and SSA3132, for a review, see33). …”

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confidence: 99%

Passive exposure to speech sounds induces long-term memory representations in the auditory cortex of adult rats

Kurkela

Lipponen

Hämäläinen

et al. 2016

Sci Rep

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Experience-induced changes in the functioning of the auditory cortex are prominent in early life, especially during a critical period. Although auditory perceptual learning takes place automatically during this critical period, it is thought to require active training in later life. Previous studies demonstrated rapid changes in single-cell responses of anesthetized adult animals while exposed to sounds presented in a statistical learning paradigm. However, whether passive exposure to sounds can form long-term memory representations remains to be demonstrated. To investigate this issue, we first exposed adult rats to human speech sounds for 3 consecutive days, 12 h/d. Two groups of rats exposed to either spectrotemporal or tonal changes in speech sounds served as controls for each other. Then, electrophysiological brain responses from the auditory cortex were recorded to the same stimuli. In both the exposure and test phase statistical learning paradigm, was applied. The exposure effect was found for the spectrotemporal sounds, but not for the tonal sounds. Only the animals exposed to spectrotemporal sounds differentiated subtle changes in these stimuli as indexed by the mismatch negativity response. The results point to the occurrence of long-term memory traces for the speech sounds due to passive exposure in adult animals.

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Stimulus-Specific Adaptation Beyond Pure Tones

Cited by 28 publications

References 14 publications

Visual mismatch negativity: a predictive coding view

Visual mismatch negativity: a predictive coding view

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

Passive exposure to speech sounds induces long-term memory representations in the auditory cortex of adult rats

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