Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems

Soppimath, Kumaresh S.; Aminabhavi, Tejraj M.; Dave, A. M.; Kumbar, Sangamesh G.; Rudzinski, Walter E.

doi:10.1081/ddc-120006428

Cited by 347 publications

(208 citation statements)

References 59 publications

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“…In order to overcome these problems, many approaches have been adopted for protecting proteins such as encapsulation of the insulin within pH-sensitive hydrogels [10], liposomes [11], permeation enhancer, enzyme inhibitor [12] and nanoparticles [13]. Among these approaches, nanoparticulate systems have attracted special interest for three reasons.…”

Section: Introductionmentioning

confidence: 99%

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Goswami¹,

Bajpai²,

Bajpai³

2012

Journal of Experimental Nanoscience

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In the present investigation, alginate nanoparticles have been prepared and characterised by various techniques such as FTIR, SEM, particle size analysis and surface charge measurements. It was found from both the SEM and particle size analysis that average size of the particle was about 40 nm. The particles were loaded with insulin and the release kinetics of insulin was studied in PBS medium. The results indicated that when percent loading increases from 11.7 to 38.9, the released amount of insulin increased from 18% to 60% of the loaded drug. The effect of composition of nanoparticles, pH and temperature of the release medium was examined on the amount of released insulin. It was observed when that amount of alginate in the feed mixture was varied from 1.0 to 2.0 g, the prepared nanoparticles showed a decreasing tendency to release insulin. Similarly, upon increasing the concentration of crosslinker in the range 0.5-1.1 mM, the release of insulin constantly decreased. The chemical stability of the loaded drug was assessed especially under highly acidic conditions of artificial gastric juice and it was noticed that even in harsh acidic environment (pH 1.2) the insulin remains chemically stable. The in vitro blood compatibility of nanoparticles was also investigated and it was found that for a definite composition of nanoparticles, protein adsorption and percent haemolysis were minimum which suggested for an optimum blood compatibility of alginate nanoparticles of definite composition. Thus, it can be conclusively stated that the calcium alginate nanoparticles prepared by emulsion crosslinking method show potential to be developed as oral formulation for insulin delivery.

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Section: Introductionmentioning

confidence: 99%

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Goswami¹,

Bajpai²,

Bajpai³

2012

Journal of Experimental Nanoscience

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“…[22][23][24] Doğal polimerler, doğal ekstrasellüler komponentlere ve biyolojik çevrelerine benzerlikleri, ayrıca, düşük toksisite, azalmış enflamatuar yanıt ve doğal sistemlerde bozunabilirliği gibi ek avantajları nedeniyle büyüme faktörlerini taşınmasında en sık kullanılan materyallerdir. 23,24 Diğer doğal ve sentetik materyaller ile kombine olarak kullanılabilen kollajen jel, mikropartikül ve diğer modifiye formları periodontal rejenerasyonda büyüme faktörlerinin taşınmasında kapsamlı olarak değerlendi-rilmiştir. Bugüne kadar Yönlendirilmiş Doku Rejenerasyonu (YDR) membranları, sünger/hidrojel büyüme faktörü taşıma sistemleri ve doku iskelelerini içeren kollajen bazlı araçlar, periodontal rejenerasyon uygulamalarının geleceğinde önemli bir yere sahiptir.…”

Section: Doğal Biyomateryal Iskelelerunclassified

Peri̇odontal Doku Mühendi̇sli̇ği̇nde Kullanilan İskele Yapilari

Bengi¹,

Saygun²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…Thermoresponsive PNIPAM has been used in many different applications ranging from scaffolding for tissue engineering [99], cell release from surfaces using low temperature lift-off [114], as a thermo-sensitive glue for retinal implants [115], microgels for biosensing [116],and vehicles for drug delivery including hydrogels, liposomes, and nanoparticles [117][118][119]. To the best of our knowledge, PNIPAM has not been applied in an aerosolized form as a vehicle for drug delivery.…”

Section: Aerosolized Pnipammentioning

confidence: 99%

Drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy

Floyd

Galperin

Ratner

2015

J Biomedical Materials Res

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Departments of Bioengineering and Chemical EngineeringThe grim prognosis for patients diagnosed with malignant gliomas necessitates the development of new therapeutic strategies for localized and sustained drug delivery to combat tumor drug resistance and regrowth. Here we introduced the novel formulation of drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy (DREAM BIG Therapy) that is applied post-resection. DREAM BIG Therapy consists of three types of microspheres [poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL)] containing various encapsulated chemotherapeutics, suspended in a degradable, aqueous poly(Nisopropylacrylamide) (PNIPAM) solution. The thermoresponsive PNIPAM solution is capable of suspending drug encapsulated microspheres at room temperature which can be "sprayed on" the post-surgical site. The physiological temperature of the treatment site (37°C) would cause PNIPAM solution to solidify and form an adherent gel layer with entrapped microspheres, providing intimate contact with remaining tumor cells. Over time, PLGA (rapid degradation), PLA (medium speed degradation), and then PCL (slow degradation) microspheres would break iv down, releasing their drug payloads in a sequential, multi-drug release directly to the tumor site, addressing cancerous regrowth and tumor drug resistance. This dissertation will address the development of DREAM BIG Therapy, from microsphere formulation to pilot in vivo studies.Initial work focused on developing blank and drug encapsulated microspheres using emulsion techniques. Preliminary studies utilized rhodamine B as a model drug for encapsulation in PLGA, PLA, and PCL particles and optimized formulation parameters to achieve a high encapsulation. Then, gefitinib, IgG, and lomustine were encapsulated in PLGA, PLA, and PCL microspheres, respectively, achieving encapsulation efficiencies greater than 80% and drug loadings greater than 0.3%. The in vitro release of gefitinib and IgG were also studied. Gefitinib released from PLGA microspheres over 40 days while the release of IgG from PLA microspheres was slower, over a year long period.The microsphere-PNIPAM system was tested for aerosolized application ex vivo. The aqueous PNIPAM solution suspended the microspheres and was aerosolized before phase transitioning to an adherent gel layer on the tissue, entrapping the microspheres on the tissue surface. Finally, when tested in vivo, the gefitinib encapsulated PLGA microspheres entrapped in PNIPAM slowed the tumor volume growth of a subcutaneous C6 glioma in comparison to blank PLGA microspheres entrapped in PNIPAM. Overall, this research confirms the potential of DREAM BIG therapy for future use with multiple chemotherapeutics and microsphere types to combat gliomas at a localized site.v

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Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems

Cited by 347 publications

References 59 publications

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Calcium alginate nanocarriers as possible vehicles for oral delivery of insulin

Peri̇odontal Doku Mühendi̇sli̇ği̇nde Kullanilan İskele Yapilari

Drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy

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