Abstract:Affinity precipitation uses reversibly water-soluble affinity macroligands, i.e. stimulus-responsive polymers bearing one or several affinity ligands, to first capture and then co-precipitate a target molecule. Conventional, polymeric AML tend to suffer from a pronounced heterogeneity in both the structure of the polymer backbone and the affinity constants. In this paper a novel type of homogeneous, oligomeric AML is proposed, which carries one affinity ligand per AML in terminal position. The homogeneity of t… Show more
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