Stimulus-responsive curcumin-based polydopamine nanoparticles for targeting Parkinson’s disease by modulating α-synuclein aggregation and reactive oxygen species

Li, Lei; Tu, Qiuxia; Zhang, Xiaohe; Song, Xiang; Xiao, Bo; Zhai, Suzhen; Yu, Haijun; Tang, Lei; Guo, Bing; Chen, Xiaozhong; Zhang, Chunlin

doi:10.1016/j.cej.2023.141606

Cited by 10 publications

(16 citation statements)

References 60 publications

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“…In general, the use of curcumin is always accompanied by a solubilization stage, whatever the vehicle strategy [21,27,28,52], and this introduces an extra variable in the analysis of the results obtained. This is why building nanoparticles with curcumin, without the use of organic solvents, and knowing the maximum concentration of PDA use without toxic effect on crops (0.32 mg/l), allows us to evaluate the effects and attribute them completely to the use of curcumin (0.05 µM), loaded in that harmless concentration of PDA.…”

Section: Discussionmentioning

confidence: 99%

“…The approach shown in this work represents a novelty in the procedure of its delivery, where one of its main virtues is based on the elimination of the undesirable effect of the carrier used. Additionally, taking into account the pH dependence that curcumin release has shown in different contexts [49][50][51][52], we understand that the incorporation of the dialysis step after the curcumin-loaded nanoparticles has resulted in a signi cant improvement in the quality of the nanoparticles obtained and in their innocuousness as a carrier at the biological level.…”

Section: Discussionmentioning

confidence: 99%

“…Among other alternative approaches, the use of nanoparticles as delivery systems is a successful strategy [43][44][45]. Recently, polydopamine (PDA) nanoparticles have been used not only as coatings and surface functionalization [46,47] but also as vehicles of different compounds [48][49][50][51][52]. Some studies have used PDA to vehicle curcumin with some differences.…”

Section: Introductionmentioning

confidence: 99%

“…The literature thus points to the sensitivity and dependence of curcumin release from PDA nanoparticles in response to the pH of the medium. The different effects of curcumin on the dose used, evidence its hormetic action, especially when considering the use of these nanoparticles at the biological level [50][51][52].…”

Section: Introductionmentioning

confidence: 99%

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A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures

Alberdi,

Martínez-Busi,

Arrarte

et al. 2024

Preprint

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Curcumin is a polyphenol extracted from Curcuma longa’s roots. Low doses of curcumin are related to anti-inflammatory, antioxidant, and neuroprotective effects, while high doses are used for their lethality. This diversity of behaviors allows us to understand curcumin as a compound with hormetic action. Due to its strongly hydrophobic character, curcumin is often solubilized in organic compounds. Despite their importance in experimental design, the specific biological impact of these vehicles alone is rarely documented. In this way, we have recently reported the undesirable and occasionally irreversible effects of alcohol and DMSO on the viability of primary Schwann cell cultures. In this scenario, the use of nanoparticles as delivery systems has become a successful alternative strategy for these compounds. In the present work, we describe the structure of Polydopamine (PDA) nanoparticles, loaded with a low dose of curcumin (Curc-PDA) without the use of additional organic solvents, characterized by transmission/scanning electron microscopy, and diffraction light scattering. We analyzed the curcumin released using Ultra-High-Pressure-Liquid Chromatography with a Mass-Spectrometry detector, and we found two different forms of curcumin. Small increased cell viability and proliferation were observed in endoneurial fibroblast and Schwann cell primary cultures when Curc-PDA was steadily supplied for 5 days. Furthermore, opposite to that observed in front of organic solvents, PDA alone showed no effect over endoneurial fibroblast or Schwann cell viability nor proliferation. These results confirm the properties of curcumin at very low doses, thus widening its therapeutic window thanks to the increased bioavailability provided by our biological approach.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures

Alberdi,

Martínez-Busi,

Arrarte

et al. 2024

Preprint

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show abstract

“…Scavenge ROS, prevent α-synuclein fibrillation and cause fibrils to disaggregate. [136] Abbreviations: Nrf2, nuclear factor erythropoie-like 2; PD, Parkinson's disease; PFFs, preformed fibrils; ROS, reactive oxygen species; TFEB, transcription factor EB.…”

Section: Nanoparticles Applications Mechanism Referencesmentioning

confidence: 99%

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Liu

Hua

Zheng

et al. 2023

MedComm – Biomaterials and Applications

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With the aging of global population, the early diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during the past decades, PD as the second largest neurodegenerative disease is still incurable. In the clinical practice, PD patients are mainly treated by drugs, and supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve the symptoms of motor disorder, and cannot stop the progression of PD. Compared with small molecular drugs, nanoparticles exhibit multiple functions in the neuroprotection and neurorepair due to their tunable physical and chemical properties, easy modification and functionalization. Herein, we first briefly review the characteristics of nanoparticles crossing the blood–brain barrier, which is a primary challenge for the treatment of PD. Then, we summarize the pathologic mechanisms of PD and comprehensively discuss the novel PD therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors and genes, and transplanting stem cells. This review aims to highlight the great potential of advanced nanoparticles in the therapy of PD.

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Curcumin Nanoformulations in Neurodegenerative Diseases

Kakkar,

Kumari,

Kaur

et al. 2023

Curcumin and Neurodegenerative Diseases

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Stimulus-responsive curcumin-based polydopamine nanoparticles for targeting Parkinson’s disease by modulating α-synuclein aggregation and reactive oxygen species

Cited by 10 publications

References 60 publications

A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures

A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Curcumin Nanoformulations in Neurodegenerative Diseases

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