Stimulus pattern related plasticity of synapses between cones and horizontal cells in carp retina

Hu, Jianfeng; Liu, Yu; Liang, Pei-Ji

doi:10.1016/s0006-8993(99)02472-5

Cited by 11 publications

(16 citation statements)

References 12 publications

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“…This stimulation of the mitochondrial ATP in ganglion cells results is an increase of their sensitivity to the incoming cone-LHC (Light Horizontal Cells) signals. The end result is a reinforcement of the output to the suprachiasmatic nucleus (SCN), and therefore to the thalamus and the hypothalamus [3,6,18]; the reinforcement may be also due, in addition, to a possible mechanism of flicking-induced short term plasticity in retinal cone-LHC synapses [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…We have shown that this response, consistent with the drive of the frequency and the augmentation of the voltage of the alpha rhythms, is far more significant with the RED-LED than GREEN-LED or BLUE-LED or WHITE-LED (three-chrome) light flashing. We stem the hypothesis that the amplitude increase and phase reset of the alpha waves produced by RED-LED flashing at 10 Hz may be due either to photobiomodulation on the cytochromo c oxidase [4,5] and/or of the photopigment melanopsin, at the level of the retinal ganglion cells, that reinforce the incoming cone-LHC signal and therefore the projection to the SCN [6] or to reinforcement of postsynaptic short term responsiveness, in retinal cone-LHC synapse, due to repetitive stimulation [7,8] or both. We may speculate that the increase of amplitude and phase reset of alpha rhythms, due to flashing at 10 Hz, is primarily modulated in the retina.…”

Section: Introductionmentioning

confidence: 99%

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Alpha Rhythms Response to 10 Hz Flicker Is Wavelength Dependent

Milone¹,

Minelli²,

Cian³

2013

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Since Adrian and Metthew [1], light may be considered the dominant stimulus for the brain. This statement is confirmed after the discovery of the suprachiasmatic nucleus (SCN) that regulates the master biological clock [2]. In 1998 the discovery of photopigment melanopsin in the ganglion cells of the retina, give new insight in the importance of the light in the pathophysiology of the brain [3]. We have studied the effect of flashing at 10 Hz with LED light of different wavelength on the response of the alpha system. We have shown that this response, consistent with the drive of the frequency and the augmentation of the voltage of the alpha rhythms, is far more significant with the RED-LED than GREEN-LED or BLUE-LED or WHITE-LED (three-chrome) light flashing. We stem the hypothesis that the amplitude increase and phase reset of the alpha waves produced by RED-LED flashing at 10 Hz may be due either to photobiomodulation on the cytochromo c oxidase [4,5] and/or of the photopigment melanopsin, at the level of the retinal ganglion cells, that reinforce the incoming cone-LHC signal and therefore the projection to the SCN [6] or to reinforcement of postsynaptic short term responsiveness, in retinal cone-LHC synapse, due to repetitive stimulation [7,8] or both. We may speculate that the increase of amplitude and phase reset of alpha rhythms, due to flashing at 10 Hz, is primarily modulated in the retina.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alpha Rhythms Response to 10 Hz Flicker Is Wavelength Dependent

Milone¹,

Minelli²,

Cian³

2013

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“…Experiments were performed on adult carp (Carassius auratus, body length 15-20 cm) retinas following the procedure similar to the previous report [10]. All procedures strictly conformed to the humane treatment and use of animals as prescribed by the Association for Research in Vision and Ophthalmology.…”

Section: Methodsmentioning

confidence: 99%

Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina

Luo¹,

Liang

2003

Brain Research Bulletin

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The role of presynaptic metabotropic glutamate receptor (mGluR) on the interaction of red-and green-cone signals was investigated in luminosity-type horizontal cell (LHC) of isolated carp retina. It was found that a dim red background could enhance LHC's light response to green stimulus, and a dim green background was also able to increase the cell's response to red flash. Such mutual color enhancement was eliminated by application of groups II and III mGluR antagonist (S)-methyl-4-carboxyphenyl-glycine (MCPG). Furthermore, inhibition of glutamate uptake by using d-aspartate (d-Asp) or dl-threo-␤-hydroxy-aspartic acid (THA) completely blocked the mutual enhancement of color signals in LHC. However, the GABAergic feedback pathway in the outer retina was unnecessarily involved.

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“…Experimental procedure was described in a previous report (Hu et al 2000). In brief, adult carp (Carassius auratus, body length 15-20 cm) retina was used.…”

Section: Intracellular Recordingmentioning

confidence: 99%

“…It was previously found in this laboratory that in the synapse between retinal luminosity-type horizontal cell (LHC) and cone photoreceptors, where both the pre-and postsynaptic signals were graded potentials, the efficacy of synaptic transmission was dependent on the stimulus pattern and the activity of relevant neurons. Intracellular recordings made from carp LHC showed that repetitive red flashes were effective in inducing a short-term enhancement of the cell's responsiveness to the red light (Hu et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Possible mechanism of flicking-induced short-term plasticity in retinal cone-LHC synapse: a computational study

Jin

Hu²,

Liang

2004

Biol. Cybern.

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In retinal cone-HC synapse, it has been found that repetitive stimulation could induce postsynaptic short-term responsiveness enhancement. However, the detailed mechanism underlying this short-term plasticity in the retinal graded neurons remains unclear. In this study, based on an ion-channel model described using Hodgkin--Huxley equations, the possible mechanism of repetitive-stimulation-induced short-term plasticity in the synapse between retinal cones and horizontal cells was investigated. The computational simulation results, together with evidence from experimental observations, suggest that the short-term modification of signal transmission between the retinal graded neurons is likely to be attributed to the regulatory effects that calcium-dependent process exerts on the single-channel properties of the postsynaptic AMPA receptors.

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Stimulus pattern related plasticity of synapses between cones and horizontal cells in carp retina

Cited by 11 publications

References 12 publications

Alpha Rhythms Response to 10 Hz Flicker Is Wavelength Dependent

Alpha Rhythms Response to 10 Hz Flicker Is Wavelength Dependent

Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina

Possible mechanism of flicking-induced short-term plasticity in retinal cone-LHC synapse: a computational study

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