Stimulus-induced gamma power predicts the amplitude of the subsequent visual evoked response

Es, Mats W.J. van; Schoffelen, Jan‐Mathijs

doi:10.1016/j.neuroimage.2018.11.029

Cited by 20 publications

(15 citation statements)

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“…In ASD, TMS can change some of the core deficits, more specifically, those impairments in self-monitoring that constitute our supervisory attentional system [ 10 , 29 , 40 , 41 , 68 ]. Higher amplitude of early evoked gamma activity has been correlated to faster behavioral responses, which could constitute impulsive behaviors [ 69 ]. Indeed, results from previous trials suggest that individuals with ASD have a reduced sensitivity for monitoring errors (i.e., a diminished response time after committing an error) and instituting corrective actions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Transcranial Magnetic Stimulation Therapy on Evoked and Induced Gamma Oscillations in Children with Autism Spectrum Disorder

et al. 2020

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Autism spectrum disorder (ASD) is a behaviorally diagnosed neurodevelopmental condition of unknown pathology. Research suggests that abnormalities of elecltroencephalogram (EEG) gamma oscillations may provide a biomarker of the condition. In this study, envelope analysis of demodulated waveforms for evoked and induced gamma oscillations in response to Kanizsa figures in an oddball task were analyzed and compared in 19 ASD and 19 age/gender-matched neurotypical children. The ASD group was treated with low frequency transcranial magnetic stimulation (TMS), (1.0 Hz, 90% motor threshold, 18 weekly sessions) targeting the dorsolateral prefrontal cortex. In ASD subjects, as compared to neurotypicals, significant differences in evoked and induced gamma oscillations were evident in higher magnitude of gamma oscillations pre-TMS, especially in response to non-target cues. Recordings post-TMS treatment in ASD revealed a significant reduction of gamma responses to task-irrelevant stimuli. Participants committed fewer errors post-TMS. Behavioral questionnaires showed a decrease in irritability, hyperactivity, and repetitive behavior scores. The use of a novel metric for gamma oscillations. i.e., envelope analysis using wavelet transformation allowed for characterization of the impedance of the originating neuronal circuit. The results suggest that gamma oscillations may provide a biomarker reflective of the excitatory/inhibitory balance of the cortex and a putative outcome measure for interventions in autism.

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Section: Discussionmentioning

confidence: 99%

Effects of Transcranial Magnetic Stimulation Therapy on Evoked and Induced Gamma Oscillations in Children with Autism Spectrum Disorder

et al. 2020

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“…While, in principle, this is possible, the current pattern of results is unlikely to be related to enhanced gamma power. First, the power of sensory gamma oscillations was previously shown to be associated with faster response times for both visual and tactile stimuli (Krebber et al, 2015; van Es and Schoffelen, 2019). Thus, enhanced sensory gamma power should speed, not delay, responses.…”

Section: Discussionmentioning

confidence: 99%

Synchronization of Sensory Gamma Oscillations Promotes Multisensory Communication

Misselhorn

Schwab

Schneider

et al. 2019

eNeuro

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Rhythmic neuronal activity in the gamma range is a signature of cortical processing and its synchronization across distant sites has been proposed as a fundamental mechanism of network interactions. While this has been shown within sensory streams, we tested whether cross talk between the senses relies on similar mechanisms. Direct sensory interactions in humans (male and female) were studied with a visual-tactile amplitude matching paradigm. In this task, congruent stimuli are associated with behavioral benefits, which are proposed to be mediated by increased binding between sensory cortices through coherent gamma oscillations. We tested this hypothesis by applying 4-in-1 multi-electrode transcranial alternating current stimulation (tACS) with 40 Hz over visual and somatosensory cortices. In phase stimulation (0°) was expected to strengthen binding and thereby enhance the congruence effect, while anti-phase (180°) stimulation was expected to have opposite effects. Gamma tACS was controlled by alpha (10 Hz) and sham stimulation, as well as by applying tACS unilaterally while visual-tactile stimuli were presented lateralized. Contrary to our expectations, gamma tACS over the relevant hemisphere delayed responses to congruent trials. Additionally, reanalysis of EEG data revealed decoupling of sensory gamma oscillations during congruent trials. We propose that gamma tACS prevented sensory decoupling and thereby limited the congruence effect. Together, our results favor the perspective that processing multisensory congruence involves corticocortical communication rather than feature binding. Furthermore, we found control stimulation over the irrelevant hemisphere to speed responses under alpha stimulation and to delay responses under gamma stimulation, consistent with the idea that contralateral alpha/gamma dynamics regulate cortical excitability.

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“…Existing evidence (Bahramisharif et al, 2013;Jensen et al, 2014;Roux et al, 2013;Spaak et al, 2012) and current theories on the functional role of the alpha band (Bonnefond et al, 2017;Jensen and Mazaheri, 2010) suggest that the pulsed inhibition caused by alpha oscillations, which shortens the duty cycle, occurs by means of cross-frequency interactions with the gamma band. Importantly, although gamma activity is often associated with stimulus processing (Fries et al, 2007; but see Ray and Maunsell, 2015), alpha-gamma interactions have been consistently recorded during rest and prestimulus windows (Bahramisharif et al, 2013;Osipova et al, 2008;Spaak et al, 2012; but see Ray and Maunsell 2015), suggesting their crucial role in shaping the perceptual outcome (Ni et al, 2016a;van Es and Schoffelen, 2019). Figure 3, the relationship between alpha and gamma oscillations is regulated both by amplitudeamplitude coupling (AAC), i.e., alpha power increase associated with gamma decrease, and by phaseamplitude coupling (PAC) interactions, i.e., gamma power nested within the alpha phase (Spaak et al, 2012).…”

Section: Alpha Inhibition Through Alpha-gamma Cross-frequency Interacmentioning

confidence: 99%

Modelling the Effects of Ongoing Alpha Activity on Visual Perception: The Oscillation-Based Probability of Response

Zazio

Schreiber²,

Miniussi

et al. 2019

Preprint

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HIGHLIGHTS-A novel, interdisciplinary model to link prestimulus oscillations and perception -Alpha-gamma cross-frequency predicts probability of response to visual stimuli -Different meso-scale neural mechanisms selectively affect the psychometric function ABSTRACT Substantial evidence has shown that ongoing neural activity significantly contributes to how the brain responds to upcoming stimuli. In visual perception, a considerable portion of trial-to-trial variability can be accounted for by prestimulus magneto/electroencephalographic (M/EEG) alpha oscillations, which play an inhibitory function by means of cross-frequency interactions with gamma-band oscillations. Despite the fundamental theories on the role of oscillations in perception and cognition, a clear theorization of the neural mechanisms underlying prestimulus activity effects that includes electrophysiological phenomena at different scales (e.g., local field potentials and macro-scale M/EEG) is still missing. Here, we present a model called the oscillationbased probability of response (OPR), which directly assesses the link between meso-scale neural mechanisms, macro-scale M/EEG, and behavioural outcome. The OPR model includes distinct meso-scale mechanisms through which alpha oscillations modulate M/EEG gamma activity, namely, by decreasing a) the amplitude and/or b) the degree of neural synchronization of gamma oscillations. Crucially, the OPR model makes specific predictions on the effects of these mechanisms on visual perception, as assessed through the psychometric function. SIGNIFICANCE STATEMENT:The oscillation-based probability of response (OPR) is grounded on a psychophysical approach focusing on the psychometric function estimation and may be highly informative in the study of ongoing brain activity because it provides a tool for distinguishing different neural mechanisms of alpha-driven modulation of sensory processing.

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Stimulus-induced gamma power predicts the amplitude of the subsequent visual evoked response

Cited by 20 publications

References 50 publications

Effects of Transcranial Magnetic Stimulation Therapy on Evoked and Induced Gamma Oscillations in Children with Autism Spectrum Disorder

Effects of Transcranial Magnetic Stimulation Therapy on Evoked and Induced Gamma Oscillations in Children with Autism Spectrum Disorder

Synchronization of Sensory Gamma Oscillations Promotes Multisensory Communication

Modelling the Effects of Ongoing Alpha Activity on Visual Perception: The Oscillation-Based Probability of Response

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