Stimulus effects of extremely low‐frequency electric field exposure on calcium oscillations in a human cortical spheroid
Atsushi Saito,
Takeo Shiina,
Yoichi Sekiba
Abstract:High‐intensity, low‐frequency (1 Hz to 100 kHz) electric and magnetic fields (EF and MF) cause electrical excitation of the nervous system via an induced EF (iEF) in living tissue. However, the biological properties and thresholds of stimulus effects on synchronized activity in a three‐dimensional (3D) neuronal network remain uncertain. In this study, we evaluated changes in neuronal network activity during extremely low‐frequency EF (ELF‐EF) exposure by measuring intracellular calcium ([Ca2+]i) oscillations, … Show more
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