Stimulus control of maternal responsiveness to Norway rat ( Rattus norvegicus) pup ultrasonic vocalizations.

Farrell, William J.; Alberts, Jeffrey R.

doi:10.1037/0735-7036.116.3.297

Cited by 68 publications

(45 citation statements)

References 22 publications

(70 reference statements)

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“…Mother rats (Rattus norvegicus) approach and maintain proximity to a pup that is emitting cries (ultrasonic vocalizations) significantly more than do virgin rats [25]. This study showed that a warm, silent pup together with recorded ultrasounds was required to elicit approach of maternal or virgin females, the former remaining in proximity of the pup for a significantly longer period of time.…”

Section: Crying and Parental Behaviormentioning

confidence: 81%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

180

132

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Crying is a universal vocalization in human infants, as well as in the infants of other mammals. Little is known about the neural structures underlying cry production, or the circuitry that mediates a caregiver's response to cry sounds. In this review, the specific structures known or suspected to be involved in this circuit are identified, along with neurochemical systems and hormones for which evidence suggests a role in responding to infants and infant cries. In addition, evidence that crying elicits parental responses in different mammals is presented. An argument is made for including 'crying' as a functional category in the vocal repertoire of all mammalian infants (and the adults of some species). The prevailing neural model for crying production considers forebrain structures to be dispensable. However, evidence for the anterior cingulate gyrus in cry production, and this structure along with the amygdala and some other forebrain areas in responding to cries is presented.

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Section: Crying and Parental Behaviormentioning

confidence: 81%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

180

132

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“…Thus, the association between locomotor activity and USV may increase maternal attention and care via visual stimuli (Weller & Dubson, 1998), in addition to the already reported role of USVs in modulating maternal behavior (Ehret, 1980;Farrell & Alberts, 2002a,b;Noirot, 1972Noirot, , 1974Sewell, 1970;Smotherman et al, 1974). An additive value of two sensory modalities (viz., the olfactory and acoustic ones) in stimulating the maternal response toward the pup has been described previously (Farrell & Alberts, 2002b;Smotherman et al, 1974). Moreover, pup movements also may enhance sound propagation, favoring detection by the mother.…”

Section: Discussionmentioning

confidence: 95%

Neonatal behaviors associated with ultrasonic vocalizations in mice (mus musculus): A slow‐motion analysis

Branchi

Santucci

Puopolo

et al. 2003

Developmental Psychobiology

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Infant rodents emit ultrasonic vocalizations (USVs) when isolated from the mother and littermates. While USVs reportedly promote maternal behavior, their communicatory role is still controversial. We performed a detailed behavioral characterization in 7-day-old CD-1 Swiss mice to describe (a) behavioral patterns accompanying or immediately preceding or following the USV and (b) how selected USV features are modulated according to the behavioral pattern being performed. The present results represent an ethogram of mouse pup behavior in close temporal proximity to USV, providing further information to evaluate the functional role of USVs in the framework of the mother-offspring relationship. A significant increase of head rising behavior immediately prior to the USV and a behavioral activation displayed by pups in conjunction with it suggest that pups behave in a way that may favor interaction with their mothers.

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“…This distress behaviour is intended to elicit maternal attention and retrieval, as well as to modulate maternal care behaviour by stimulating prolactin production (Noirot, 1972;Hashimoto et al, 2001;Farrell and Alberts, 2002). These distress behaviours can be recorded and analysed both quantitatively and qualitatively in order to measure levels of distress-like behaviour in both infant mice and rats (Groenink et al, 2008;Scattoni et al, 2009).…”

Section: Separation-induced Ultrasonic Vocalizationsmentioning

confidence: 99%

The age of anxiety: role of animal models of anxiolytic action in drug discovery

Cryan¹,

Sweeney²

2011

British J Pharmacology

236

188

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Anxiety disorders are common, serious and a growing health problem worldwide. However, the causative factors, aetiology and underlying mechanisms of anxiety disorders, as for most psychiatric disorders, remain relatively poorly understood. Animal models are an important aid in giving insight into the aetiology, neurobiology and, ultimately, the therapy of human anxiety disorders. The approach, however, is challenged with a number of complexities. In particular, the heterogeneous nature of anxiety disorders in humans coupled with the associated multifaceted and descriptive diagnostic criteria, creates challenges in both animal modelling and in clinical research. In this paper, we describe some of the more widely used approaches for assessing the anxiolytic activity of known and potential therapeutic agents. These include ethological, conflict-based, hyponeophagia, vocalization-based, physiological and cognitive-based paradigms. Developments in the characterization of translational models are also summarized, as are the challenges facing researchers in their drug discovery efforts in developing new anxiolytic drugs, not least the ever-shifting clinical conceptualization of anxiety disorders. In conclusion, to date, although animal models of anxiety have relatively good validity, anxiolytic drugs with novel mechanisms have been slow to emerge. It is clear that a better alignment of the interactions between basic and clinical scientists is needed if this is to change.

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Stimulus control of maternal responsiveness to Norway rat ( Rattus norvegicus) pup ultrasonic vocalizations.

Cited by 68 publications

References 22 publications

Neural circuits underlying crying and cry responding in mammals

Neural circuits underlying crying and cry responding in mammals

Neonatal behaviors associated with ultrasonic vocalizations in mice (mus musculus): A slow‐motion analysis

The age of anxiety: role of animal models of anxiolytic action in drug discovery

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