Stimuliresponsive, auf Biomolekülen basierende Hydrogele und ihre Anwendungen

Vázquez‐González, Margarita; Willner, Itamar

doi:10.1002/ange.201907670

Cited by 20 publications

(1 citation statement)

References 439 publications

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“…30,31 Besides the crosslinking of polymer chains by means of duplex nucleic acid bridges, 32 hydrogels cooperatively stabilized by duplex nucleic acids and stimulus-responsive nucleic acid crosslinking units exhibit signal-triggered stiffness functions. 33,34 For example, cytosinerich strands undergo reversible pH-triggered reconguration between random strands and i-motif structures. 35 Guanosinerich nucleic acids undergo, in the presence of K + -ions/crown ethers, reversible transitions between G-quadruplex and random strand congurations, 36 nucleic acid strands functionalized with photoisomerizable azobenzene units demonstrate light-induced formation and dissociation of duplex nucleic acids upon photoisomerization of the azobenzene units between trans and cis states, 27,37,38 and triplex T-A$T or C-G$C + nucleic acids undergo pH-stimulated reconguration of the nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

et al. 2020

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Hierarchically Structured DNA‐Based Hydrogels Exhibiting Enhanced Enzyme‐Responsive and Mechanical Properties

et al. 2020

Adv Funct Materials

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Programmable stimuli‐responsive materials have great potential in biosensing and biomedical applications. However, the slow response of DNA hydrogels to biological targets, especially bio‐macromolecules, i.e., proteins, due to the slow mass transfer within hydrogel matrices, as well as poor mechanical strength, severely hinders their extensive applications. Herein, the construction of hierarchically structured DNA hydrogels exhibiting significantly enhanced responsive and mechanical properties via a facile cryostructuration process is demonstrated. During the cryostructuration, interconnected macropores that can function as the channels for the migration of bio‐macromolecular substances, i.e., enzymes, are formed with the generated ice crystals as templates; meanwhile, densely crosslinked networks between the macropores are formed by the concentrated monomers localized in the unfrozen zones of the gelation system, leading to higher strength of the gel matrices. By programming the sequences of the DNA crosslinkers, two model hydrogels composed of enzyme‐responsive DNA structures and catalytic DNA crosslinking structures that can collaborate with enzymes to form biocatalytic cascades are constructed, and, in both systems, the hierarchically structured DNA hydrogels exhibit significantly enhanced responsive properties and mechanical strengths compared with typical DNA hydrogels. Moreover, the introduction of thermosensitive polymers can further endow the system with thermally switchable responsive properties.

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Engineered Multifunctional Artificial Dermis for Infected Burn Wound Healing

Wu,

Li,

Liu

et al. 2024

Adv Funct Materials

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Burn wound healing is a dynamic and interconnected process, with the complex status of the extracellular matrix (ECM) potentially leading to bacterial infections, drug resistance, or even fatality. However, it remains a grand challenge to assemble a skin‐like material showing similar biological properties as healthy ECM to accelerate burn healing. In this study, the ECM composition is closely mimicked and adaptive multifunctional artificial dermis is developed by leveraging Ag─S bonds, supramolecular interactions among recombinant proteins, Ag+, and hyaluronic acid (HA). The artificial dermis exhibits long‐lasting broad‐spectrum antibacterial activity, achieved though controlled Ag+ release via Ag─S bonds, supramolecular interactions, and recombinant protein‐guided multi‐level assembly, reaching a steady plateau of 83.7% in the later stage. It is found that inflammation is reduced by downregulating IL‐6 and TGF‐β expression. Furthermore, the epidermal growth factor (EGF) within the recombinant proteins stimulates Col1α, ELN, and CD31 upregulation, facilitating ECM remodeling. These adaptive multifunctional artificial dermis effectively address wound infections, accelerate collagen deposition, promote re‐epithelialization, and enhance angiogenesis in infected wounds, highlighting their potential to revolutionize burn wound treatment and offering a promising avenue to holistic care.

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Stimuliresponsive, auf Biomolekülen basierende Hydrogele und ihre Anwendungen

Cited by 20 publications

References 439 publications

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

Hierarchically Structured DNA‐Based Hydrogels Exhibiting Enhanced Enzyme‐Responsive and Mechanical Properties

Engineered Multifunctional Artificial Dermis for Infected Burn Wound Healing

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