Abstract:Apex vessels (previously known as PEAK vessels) are an important element of the dissolution scientist's toolbox and are frequently used in pharmaceutical drug product development settings. However, their use in development has not translated widely into use in the final approved quality control (QC) method. This Stimuli article aims to demonstrate the significant benefit of the apex vessel relative to the standard vessel in overcoming coning for formulations that contain dense insoluble excipients. Industrial … Show more
“…Dr. Nickerson also discussed a Stimuli article that was published in Pharmacopeial Forum in collaboration with members of IQ Dissolution Working Group, AAPS In Vitro Release and Dissolution Testing Community, and apex vessel manufacturers (10). The goal of the article was to seek acceptance of the apex vessel as an alternative to the standard 1-L vessel to be used when scientifically justified.…”
Section: Part 1: Dissolution In Pharmacopeiasmentioning
“…Dr. Nickerson also discussed a Stimuli article that was published in Pharmacopeial Forum in collaboration with members of IQ Dissolution Working Group, AAPS In Vitro Release and Dissolution Testing Community, and apex vessel manufacturers (10). The goal of the article was to seek acceptance of the apex vessel as an alternative to the standard 1-L vessel to be used when scientifically justified.…”
Section: Part 1: Dissolution In Pharmacopeiasmentioning
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