Stimuli-sensitive drug delivery systems

Ahmadi, Mazaher; Madrakian, Tayyebeh; Ghoorchian, Arash; Kamalabadi, Mahdie; Afkhami, Abbas

doi:10.1016/b978-0-08-102985-5.00003-6

Cited by 12 publications

(9 citation statements)

References 111 publications

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“…The desired drug-loading capacity of polymeric micelles might be attributed to the bulky and rigid adamantane core as well as hydrophobic PLGA and PDEAEMA segments, which were advantageous to entrap more drugs. In our previous works [ 10 , 23 , 38 ], it was manifested that the length of hydrophobic segments played an important role in drug loading capacity of drug-loaded micelles, for instance, longer hydrophobic segments resulted in higher LCs values. Interestingly, with the nearly identical blocks ratio of polymer for one arm, the LCs of DOX@S-PLGA-D-P and DOX@L-PLGA-D-P were 22.9% and 21.6%, respectively, which demonstrated that the topological structure of star-shaped and linear polymers did not seem to be a key factor for drug loading capacity of the DOX-loaded micelles.…”

Section: Resultsmentioning

confidence: 99%

“…In an attempt to achieve improved therapeutic efficacy as well as minimal adverse effects, drug delivery systems with stimuli-responsive function that are able to release their drugs cargo in response to changes in pH, temperature or redox conditions have attracted more and more concerns [ 4 , 5 , 6 , 7 ]. Of these stimuli, pH-responsive amphiphilic polymers are currently of considerable academic and clinical interest since well-defined pH gradients exist in different tissues and cellular compartments, for instance, the pH of blood or normal tissues is 7.4, while the pH of extracellular environment and lysosomes of tumor tissues are about pH 6.4 and pH 5.0, respectively [ 8 , 9 , 10 , 11 , 12 , 13 ]. Xu and co-workers [ 14 ] developed a pH-responsive polymeric micelle based on block copolymer poly(ethylene glycol)- b -poly[2-(diisopropylamino) ethyl methacrylate], which exhibited proper stability in physiological environment and pH-triggered transforming capability between self-assembly and disassembly.…”

Section: Introductionmentioning

confidence: 99%

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Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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“…Different carriers have been designed using tumor parameters such as pH, enzyme levels, redox species concentration, and reactive oxygen species. It is possible to modify the drug carrier to respond to particular internal or external stimuli 4 . The distinct qualities of the impacted tissues, such as temperature, pH, redox conditions, and the overexpression of certain active molecules, are known as intrinsic stimuli.…”

Section: Introductionmentioning

confidence: 99%

On chip synthesis of a pH sensitive gefitinib anticancer drug nanocarrier based on chitosan/alginate natural polymers

Alizadeh,

Ahmadi,

Heydari Shayesteh

2024

Sci Rep

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In this research, using a microfluidic chip, a nanocarrier for the anticancer drug gefitinib was synthesized. Chitosan and alginate natural polymers were utilized for the synthesis of the nanocarrier. The synthesis of the nanocarrier comprises the interaction of secondary amine functional groups of gefitinib molecules with carboxylate functional groups of alginate polymer to form the primary nucleus followed by the formation of the nanocarrier through the self-assembly of chitosan and alginate polymers on a fabricated microfluidic chip. The chip was fabricated by laser engraving poly(methyl methacrylate) polymer sheets. The nanocarrier was characterized by FT-IR, DLS, SEM, and TEM techniques. The synthesized nanocarrier had a size distribution of 5.30 ± 2.60 nm and the encapsulation efficiency percent was 68.4% in the optimum conditions. The loading efficiency was calculated as 50.2 mg g−1 of nanocarrier. Drug release studies showed that the nanocarrier is sensitive to pH and releases more gefitinib in acidic environments. Cytotoxicity of the synthesized nanocarrier was studied on the A549 non-small cell lung cancer, and the MTT test showed that the synthesized nanocarrier has a lower IC50 value than the free drug. Also, the cytotoxicity studies showed that the materials used for the synthesis of nanocarrier do not show significant cytotoxicity. Compared to the previously reported method, the developed microfluidic-assisted method showed advantages such as a faster synthesis procedure and comparable encapsulation efficiency and loading capacity.

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“…Many other studies tried to address this question using a wide range of chemical permeation enhancers [17][18][19]. As reported, attempts have been made to utilize nanoparticles to increase the performance of controlled drug delivery [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Controlled Transdermal Iontophoresis of Insulin from Water-Soluble Polypyrrole Nanoparticles: An In Vitro Study

Tari

Khamoushian

Madrakian

et al. 2021

IJMS

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The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeability of the drug through the skin. This work aims to investigate the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of INS. WS-PPyNPs have been prepared via a simple chemical polymerization in the presence of sodium dodecyl sulfate (SDS) as both dopant and the stabilizing agent. The synthesis of the soluble polymer was characterized using field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), fluorescence spectroscopy, and Fourier transform infrared (FT–IR) spectroscopy. The loading mechanism of INS onto the WS-PPyNPs is based on the fact that the drug molecules can be replaced with doped dodecyl sulfate. A two-compartment Franz-type diffusion cell was employed to study the effect of current density, formulation pH, INS concentration, and sodium chloride concentration on anodal iontophoresis (AIP) and cathodal iontophoresis (CIP) of INS across the rat skin. Both AIP and CIP delivery of INS using WS-PPyNPs were significantly increased compared to passive delivery. Furthermore, while the AIP experiment (60 min at 0.13 mA cm–2) show low cumulative drug permeation for INS (about 20.48 µg cm−2); the CIP stimulation exhibited a cumulative drug permeation of 68.29 µg cm−2. This improvement is due to the separation of positively charged WS-PPyNPs and negatively charged INS that has occurred in the presence of cathodal stimulation. The obtained results confirm the potential applicability of WS-PPyNPs as an effective approach in the development of controlled transdermal iontophoresis of INS.

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Stimuli-sensitive drug delivery systems

Cited by 12 publications

References 111 publications

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

On chip synthesis of a pH sensitive gefitinib anticancer drug nanocarrier based on chitosan/alginate natural polymers

Controlled Transdermal Iontophoresis of Insulin from Water-Soluble Polypyrrole Nanoparticles: An In Vitro Study

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