Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

Abstract

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by pH or Mg2+ ions/ATP triggers, resulting in the release of the loads.

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

“…This strategy was utilized in imaging miR‐21 in MCF‐7, HeLa, and L02 cells. Chen et al developed MOF nanoparticles capped with DNAzymes and aptazymes as a therapeutic platform for treating cancer cells . Doxorubicin was incorporated into the porous MOF structures and the DNAzymes/aptazymes acted as a cap.…”

A RuII Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

“…However,p oor waters olubility,w eak resistance to aggregation, and low selectivity towards tumorso fR u II polypyridyl complexes limit their PDT applications as PSs. [12] To the best of our knowledge,t here is no example of MOFs modified with Ru II polypyridyl complexes by the click reaction, and research in which Ru II polypyridyl com-plexes and PTT agents as wellasanti-cancer drugs are integrated into one platform is also scarce. [10] Amongt hem,m etal-organic framework (MOF) nanocarrier-based nanoplatformsh ave been developed rapidly, becauseo ft heir high surfacea rea, substantial pore structure, and alterablel igands, whichc an produce therapeutic treatmentt hrough loadinga gents by multiple methods.…”

DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy

“…[15,16] Despite the increasing interests in DNAzyme-mediated gene silencing,c hallenges still exist in its poor cellular delivery and ineffective intracellular DNAzyme cleavage originating from insufficient cofactor supply. MOFs are also utilized as robust solid scaffolds for anchoring nucleic acids through electrostatic adsorption, [23][24][25] covalent conjugation, [26][27][28] or van der Waals interactions, [29] yet they suffer from either environmental vulnerability or tedious assembly.MOFs have been introduced as robust vessels for siRNAo rD NAzymes without stimuli-responsiveness. MOFs are also utilized as robust solid scaffolds for anchoring nucleic acids through electrostatic adsorption, [23][24][25] covalent conjugation, [26][27][28] or van der Waals interactions, [29] yet they suffer from either environmental vulnerability or tedious assembly.MOFs have been introduced as robust vessels for siRNAo rD NAzymes without stimuli-responsiveness.…”

“…MOFs are also utilized as robust solid scaffolds for anchoring nucleic acids through electrostatic adsorption, [23][24][25] covalent conjugation, [26][27][28] or van der Waals interactions, [29] yet they suffer from either environmental vulnerability or tedious assembly.MOFs have been introduced as robust vessels for siRNAo rD NAzymes without stimuli-responsiveness. [28] However,these MOFs are only used as nanocarriers without consideration of their disassociated components. [28] However,these MOFs are only used as nanocarriers without consideration of their disassociated components.…”