Stimuli responsive nanosonosensitizers for sonodynamic therapy

Jiang, Zeyu; Xiao, Wen‐Jing; Fu, Qinrui

doi:10.1016/j.jconrel.2023.08.003

Cited by 30 publications

(14 citation statements)

References 167 publications

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“…ROS are chemically active oxygen-containing molecules, including singlet oxygen ( 1 O 2 ), H 2 O 2 , O 2 •– , hydroxyl radical (•OH), and hypochlorite (OCl – ), − which play a crucial role in regulating physiology and pathology processes and are often overexpressed in various inflammatory tissues. − Therefore, the design of ROS-responsive ratiometric FL probes is of great value for the diagnosis and therapy of diseases. Song and co-workers designed a smart ratiometric NIR-II FL probe (DCNP@786s) consisting of IR786s-coated lanthanide-based down-conversion NPs (DCNPs) for the sensing of ROS in vivo and quantitatively tracking adoptive natural killer (NK) cell viability (Figure a) .…”

Section: Ratiometric Optical Imagingmentioning

confidence: 99%

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological and pathological states. Therefore, it is crucial to design imaging systems capable of realtime detection of dynamic changes in biomarkers for the accurate diagnosis and effective treatment of diseases. Recently, ratiometric imaging has emerged as a widely used technique for sensing and imaging of biomarkers due to its advantage of circumventing the limitations inherent to conventional intensity-dependent signal readout methods while also providing built-in self-calibration for signal correction. Here, the recent progress of ratiometric probes and their applications in sensing and imaging of biomarkers are outlined. Ratiometric probes are classified according to their imaging mechanisms, and ratiometric photoacoustic imaging, ratiometric optical imaging including photoluminescence imaging and self-luminescence imaging, ratiometric magnetic resonance imaging, and dual-modal ratiometric imaging are discussed. The applications of ratiometric probes in the sensing and imaging of biomarkers such as pH, reactive oxygen species (ROS), reactive nitrogen species (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, and hypoxia are discussed in detail. Additionally, this Review presents an overview of challenges faced in this field along with future research directions.

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Section: Ratiometric Optical Imagingmentioning

confidence: 99%

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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“…The SDT approach, a pioneering noninvasive cancer treatment modality, entails the activation of sonosensitizers to induce the generation of cytotoxic ROS in the presence of molecular oxygen during ultrasound (US) irradiation . Regrettably, the hypoxic tumor microenvironment significantly undermines the efficacy of SDT. − Hence, it is imperative to ensure an ample supply of O 2 to enhance the production of ROS and thereby escalate the efficiency of SDT treatment.…”

Section: Application Of Nanozymes In Enhancing Anticancer Effectsmentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralization method, and sol−gel method. Subsequently, we elucidate the catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like activities), oxidase (OXD)-like activities) and superoxide dismutase (SOD)-like activities) of transition-metal-based nanozymes along with their activity regulation strategies such as morphology control, size manipulation, modulation, composition adjustment and surface modification under environmental stimulation. Furthermore, we elaborate on the diverse applications of transition-metal-based nanozymes in anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), immunotherapy, and synergistic therapy. Finally, the challenges faced by transition-metal-based nanozymes are discussed alongside future research directions. The purpose of this review is to offer scientific guidance that will enhance the clinical applications of nanozymes based on transition metals.

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“…The implosive collapse of cavitation bubbles in inertial cavitation generates extremely high temperatures (up to 10 000 K) and enormous pressures (81 MPa) at the cavitation core. 27 Such extreme heat and pressure may decompose H 2 O into free radicals (˙OH), which can further react with endogenous substrates to produce other ROS. Owing to the localized energy release and high cooling rates, collateral damage to adjacent tissues is minimal.…”

Section: The Mechanism Of Sonocatalytic Therapymentioning

confidence: 99%