Stimuli-responsive mesoporous silica nanoparticles: A custom-tailored next generation approach in cargo delivery

Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment

“…The scientists presented a distinct consideration of MSNPs in light of their high drug loading, tunable pore sizes, ease of functionalization at the internal and external surfaces and largeSA. A noted distinction further mentioned is the adaptability of external and in situ stimulating factors, superseding the similar benefits in Au and Ag NPs due to the porous sensitivity and core–shell architecture of MSNPs [ 164 ].…”

Engineered mesoporous silica-based nanoparticles as smart chemotherapy nanodevice for bortezomib administration

“…Their solid framework, nanostructured through different organic functionalities, provides hybrid organic–inorganic nanodevices able to interact with biological structures, 5 triggering cell internalization 6 and drug release, as a response to several stimuli. 7…”

“…3,4 Their solid framework, nanostructured through different organic functionalities, provides hybrid organic-inorganic nanodevices able to interact with biological structures, 5 triggering cell internalization 6 and drug release, as a response to several stimuli. 7 MSNs have several advantages, such as high stability, good biocompatibility, regularly sized pores and tunable pore diameter in the range of 15-100 Å, large loading capacity, and ease of surface functionalization. 8,9 The availability of two different functionalizable surfaces, one internal and the other external to the pores, makes them desirable options for encapsulating therapeutic/diagnostic (theranostic) agents (e.g., drugs, miRNA, siRNA, proteins, enzymes, DNA, as well as probes for imaging applications) to be delivered to the desired target (e.g.…”

Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

“…One of the priority tasks of modern nanomedicine is the design of new, highly efficient delivery vehicles for anticancer agents. For this purpose, mesoporous SiO 2 -based nanomaterials with high biocompatibility and sorption capacity are often exploited [ 1 , 2 ]. The use of magnetic nanoparticles (MNPs) in such materials makes it possible to expand the range of their properties; in particular, it allows visualization of their biodistribution and accumulation in tissues by magnetic resonance imaging (MRI) [ 3 , 4 , 5 , 6 , 7 , 8 ] or magnetic particle imaging (MPI) [ 9 ], as well as the enhancement of their therapeutic action due to targeting and concentrating of magnetic nanocomposites in cancer cells by external magnetic stimulus [ 10 ] or due to the hyperthermia effect caused by the heating of magnetic core when an alternating magnetic field (AMF) is applied [ 11 ].…”