Stimuli-responsive layer-by-layer nanocomposites

Zhuk, Aliaksandr; Sukhishvili, Svetlana A.

doi:10.1039/c3sm00071k

Cited by 32 publications

(24 citation statements)

References 47 publications

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“…The morphology and permeability of the (TA/SGQP) microcapsules are responsive to pH and temperature because of the corresponding properties of individual star macromolecules (Supporting Information, Figure S1) . To test the permeability of the shells, fluorescein isothiocyanate (FITC) labeled dextran with various molecular weights were used as fluorescent probes . The permeability tests of the (TA/SGQP) 6 shells at different pH conditions to 150 kDa FITC‐dextran are shown in Figure and Table (see also the Supporting Information, Figure S4).…”

Section: Figurementioning

confidence: 99%

Multicompartmental Microcapsules with Orthogonal Programmable Two‐Way Sequencing of Hydrophobic and Hydrophilic Cargo Release

Ledin

Iatridi

et al. 2016

Angew Chem Int Ed

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Multicompartmental responsive microstructures with the capability for the pre-programmed sequential release of multiple target molecules of opposite solubility (hydrophobic and hydrophilic) in a controlled manner have been fabricated. Star block copolymers with dual-responsive blocks (temperature for poly(N-isopropylacrylamide) chains and pH for poly(acrylic acid) and poly(2-vinylpyridine) arms) and unimolecular micellar structures serve as nanocarriers for hydrophobic molecules in the microcapsule shell. The interior of the microcapsule can be loaded with water-soluble hydrophilic macromolecules. For these dual-loaded microcapsules, a programmable and sequential release of hydrophobic and hydrophilic molecules from the shell and core, respectively, can be triggered independently by temperature and pH variations. These stimuli affect the hydrophobicity and chain conformation of the star block copolymers to initiate out-of-shell release (elevated temperature), or change the overall star conformation and interlayer interactions to trigger increased permeability of the shell and out-of-core release (pH). Reversing stimulus order completely alters the release process.

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Section: Figurementioning

confidence: 99%

Multicompartmental Microcapsules with Orthogonal Programmable Two‐Way Sequencing of Hydrophobic and Hydrophilic Cargo Release

Ledin

Iatridi

et al. 2016

Angew Chem Int Ed

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“…We are aware that systematic studies on these novel, promising systems are needed to achieve optimal properties, for example,enhanced robustness,higher stability to HT with the choice of athermally stable initiator, and likely astimuliresponsive behavior, as shown for other composites. [38] In addition the homogeneity can be improved by as tronger wetting of the polymer substrate by the reaction solution, as identified by the present work. Therefore future effort will be spent on identifying the optimum conditions (type of polymer,a rchitecture of the polymer,t opology of the surface).…”

Section: Angewandte Chemiementioning

confidence: 59%

“…[38] In addition the homogeneity can be improved by as tronger wetting of the polymer substrate by the reaction solution, as identified by the present work. [38] In addition the homogeneity can be improved by as tronger wetting of the polymer substrate by the reaction solution, as identified by the present work.…”

Section: Methodsmentioning

confidence: 99%

Transparent Aluminium Oxide Coatings of Polymer Brushes

et al. 2016

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A novel method for the preparation of transparent Al2O3 coatings of polymers is presented. An environmental-friendly sol-gel method is employed, which implies mild conditions and low costs. A thermoresponsive brush is chosen as a model surface. X-ray photoelectron spectroscopy is used to characterize the samples during the conversion of the precursor Al(OH)3 into oxide and to prove the mildness of the protocol. The study evidences a relation between lateral homogeneity of alumina and the wettability of the polymer surface by the precursor solution, while morphology and elasticity are dominated by the polymer properties. The study of the swelling behavior of the underneath brush reveals the absence of water uptake, proving the impermeability of the alumina layer. The broad chemical and structural variety of polymers, combined with the robustness of transparent alumina films, makes these composites promising as biomedical implants, protective sheets and components for electric and optical devices.

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“…Assembly of inorganic nanoparticles within the multilayer hollow microspheres brings additional benefits by not only improving mechanical, electronic, magnetic, and optical properties of these materials, but also endowing them with the capability to transform external signals and transfer them to other shell components. Combining inorganic nanoparticles with temperature-, pH-, and=or light-responsive polymers within LbL engineered multilayer hollow microspheres yields novel platforms with unique characteristics and properties easily controllable by external stimuli [8].…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Engineered Superparamagnetic Polyelectrolyte Hybrid Hollow Microspheres With High Magnetic Content as Drug Delivery System

Liu

2015

International Journal of Polymeric Materials and Polymeric Biom

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Polyelectrolyte hybrid hollow microspheres with sandwich structure of about 450 nm have been accomplished by layer-by-layer self-assembling of two modified ferroferric oxide nanoparticles, lysine modified ferroferric oxide nanoparticles (Fe 3 O 4 -LYs) and citrate modified ferroferric oxide nanoparticles (Fe 3 O 4 -CA), as the main assembling materials via electrostatic interaction for the first time. They are superparamagnetic with saturation magnetization of 45.69 emu=g, revealing their high magnetic content of 70%. As drug delivery system, they also exhibited pH-stimuli responsive controlled release of an anticancer drug doxorubicin, following the Fickian diffusion model. Their unique structure and high magnetic content make them good candidate for targeted delivery.

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Stimuli-responsive layer-by-layer nanocomposites

Cited by 32 publications

References 47 publications

Multicompartmental Microcapsules with Orthogonal Programmable Two‐Way Sequencing of Hydrophobic and Hydrophilic Cargo Release

Multicompartmental Microcapsules with Orthogonal Programmable Two‐Way Sequencing of Hydrophobic and Hydrophilic Cargo Release

Transparent Aluminium Oxide Coatings of Polymer Brushes

Layer-by-Layer Engineered Superparamagnetic Polyelectrolyte Hybrid Hollow Microspheres With High Magnetic Content as Drug Delivery System

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