Stimuli-Responsive Hydrogels for Protein Delivery

Malta, Rafaela; Marques, Ana Camila; Costa, Paulo Cardoso da; Amaral, Maria Helena

doi:10.3390/gels9100802

Cited by 8 publications

(2 citation statements)

References 154 publications

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“…Therefore, polypeptides and proteins have always been widely studied as therapeutic agents for the treatment of various human diseases [207]. However, their physicochemical properties often render them difficult to be used as bare therapeutic agents [208]. Their incorporation in a three-dimensional hydrogel structure additionally provides a number of possibilities when it comes to therapeutic outcomes; examples of hydrogel systems loaded with polypeptides and proteins are summarized in Table 4.…”

Section: Hydrogels Loaded With Peptides Polypeptides and Proteinsmentioning

confidence: 99%

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Michalicha,

Belcarz,

Giannakoudakis

et al. 2024

Materials

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Effective wound treatment has become one of the most important challenges for healthcare as it continues to be one of the leading causes of death worldwide. Therefore, wound care technologies significantly evolved in order to provide a holistic approach based on various designs of functional wound dressings. Among them, hydrogels have been widely used for wound treatment due to their biocompatibility and similarity to the extracellular matrix. The hydrogel formula offers the control of an optimal wound moisture level due to its ability to absorb excess fluid from the wound or release moisture as needed. Additionally, hydrogels can be successfully integrated with a plethora of biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing the performance of resulting composite hydrogels in wound healing applications. In this review, the-state-of-the-art discoveries related to stimuli-responsive hydrogel-based dressings have been summarized, taking into account their antimicrobial, anti-inflammatory, antioxidant, and hemostatic properties, as well as other effects (e.g., re-epithelialization, vascularization, and restoration of the tissue) resulting from their use.

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Section: Hydrogels Loaded With Peptides Polypeptides and Proteinsmentioning

confidence: 99%

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Michalicha,

Belcarz,

Giannakoudakis

et al. 2024

Materials

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show abstract

“…Drug delivery The ability of hydrogels to respond to external stimuli, such as chemical, physical, or biological factors, has unveiled novel opportunities for the creation of intelligent materials [9,14,39,41]. This characteristic is pivotal in the conception of dynamic hydrogel systems that can adjust to varying physiological conditions, paving the way for advanced applications in smart drug delivery systems, adaptive tissue scaffolds, and responsive biomedical devices.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Advances in Hydrogel-Based Drug Delivery Systems

Liu,

Chen

2024

Gels

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Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.

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Dynamic Covalent Hydrogel as a Single‐Dose Vaccine Adjuvant for Sustained Antigen Release and Significantly Elevated Humoral Immunity

Shi,

Gao,

Zhuang

et al. 2024

Adv Healthcare Materials

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Vaccine is the most important way for fighting against infection diseases. However, multiple injections and unsatisfied immune responses are the main obstacles for current vaccine application. Herein, a dynamic covalent hydrogel (DCH) was used as a single‐dose vaccine adjuvant for eliciting robust and sustained humoral immunity. By adjusting the mass ratio of the DCH gel, we successfully realized 10 to 30 days constant release of the loaded recombinant protein antigens, and proved that sustained release of antigens could significantly improve the vaccine efficacy. When loading SARS‐CoV‐2 RBD (Wuhan and Omicron BA.1 strains) antigens into this DCH gel, an over 32,000 times and 8,000 times improvement was observed in antigen‐specific antibody titers compared to conventional Aluminum adjuvanted vaccines. The universality of this DCH gel adjuvant was confirmed in a Nipah G antigen test as well as a H1N1 influenza virus antigen test, with much improved protection of C57BL/6 mice against H1N1 virus infection than conventional Aluminum adjuvanted vaccines. This sustainably released, single‐dose DCH gel adjuvant provides a new promising option for designing next‐generation infection vaccines.This article is protected by copyright. All rights reserved

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Stimuli-Responsive Hydrogels for Protein Delivery

Cited by 8 publications

References 154 publications

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Advances in Hydrogel-Based Drug Delivery Systems

Dynamic Covalent Hydrogel as a Single‐Dose Vaccine Adjuvant for Sustained Antigen Release and Significantly Elevated Humoral Immunity

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