Stimuli-responsive dynamic hydrogels: design, properties and tissue engineering applications

Abstract

The field of tissue engineering and regenerative medicine has been evolving at a rapid pace with numerous novel and interesting biomaterials being reported. Hydrogels have come a long way in...

Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

“…[184][185][186][187][188][189] In this context, hydrogels composed of piezoelectric components could be ideal candidates owing to their softness, flexibility, deformability, and biocompatibility, all of which are highly desirable for quick response to external triggers and mimicking the ECM of biological tissues. 190 Based on these advantages, the exploration of piezoelectric hydrogels is of growing interest since they are biocompatible, stretchable and can stimulate endogenous This journal is © The Royal Society of Chemistry 2023 ''bioelectricity'' to promote tissue regeneration and repair. 191 Due to the physical features of hydrogel-based piezoelectrics that mirror biological functions, these characteristics represent a major potential for integrating biological organs and electronics.…”

Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

“…In recent years, smart stimuli-responsive (SSR) biomaterials have received increasing attention from researchers in various fields. 123–125 Other than traditional routines, stimuli-responsive biomaterials can detect externally applied stimuli or internal microenvironment changes and respond to them by changing the physical or chemical structures of materials, or catalyzing biochemical reactions, thus provoking biological effects on cells and tissues. 126,127 Stimuli-triggered therapeutic effects of SSR materials could be activated externally by photostimulation (including visible light, ultraviolet (UV) light, and near-infrared (NIR) light), 128,129 magnetic field (MF), 130,131 electrical stimulation (ES), 132,133 ultrasound (US), 134,135 and so on.…”

Macrostructure and Microenvironment Biomimetic Hydrogel: Design, Properties, and Tissue Engineering Application

“…Therefore, hydrogels employed in biomedical applications not only need to emulate the macroscopic structure of tissues but also mimic the microstructural properties of the natural extracellular matrix (ECM), effectively supporting various activities of enclosed cells in a 3D space. Fortunately, with advancements in polymer synthesis, various forms of reversible chemical and physical cross-linking have been integrated into hydrogel design as dynamic cross-linking mechanisms, giving rise to the emergence of hydrogels capable of replicating ECM’s microdynamic structural featuresdynamic structural hydrogels. , The development of multiple dynamic hydrogel forms has opened up new possibilities for the application of hydrogels as 3D matrices in biomedical contexts. − …”