Stimuli-responsive doxorubicin-loading Zr-MOF film for time-ordered tumor therapy and bone regeneration

Yan, Bangcheng; Tan, Ji; Chen, Lan; Zhang, Haifeng; Ma, Xiaohan; Qiao, Yan; Liu, Xuanyong

doi:10.1016/j.compositesb.2022.110452

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…The composite MOF coating could respond to endogenous H 2 O 2 and exogenous NIR illumination in the context of osteosarcoma to drive Fenton reaction for eliminating the tumor cells, which would significantly enhance the surface hydrophilicity of the Ti implants to recruit MSCs. [ 64 ] Meanwhile, the hydrophilic MOF surface would release Zr and Fe ions to boost the osteogenic potential of recruited MSCs to enhance local bone formation.…”

Section: Mof Coating For Ti Implant Functionalizationmentioning

confidence: 99%

Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Zhang,

Cheng,

Liu

et al. 2023

Advanced Science

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Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for the clinical intervention against bone fractures. However, the intrinsic bioinertness of Ti and its alloys often impedes the effective osseointegration of the implants, leading to severe adverse complications including implant loosening, detachment, and secondary bone damage. Consequently, new Ti implant engineering strategies are urgently needed to improve their osseointegration after implantation. Remarkably, metalorganic frameworks (MOFs) are a class of novel synthetic material consisting of coordinated metal species and organic ligands, which have demonstrated a plethora of favorable properties for modulating the interfacial properties of Ti implants. This review comprehensively summarizes the recent progress in the development of MOF‐coated Ti implants and highlights their potential utility for modulating the bio‐implant interface to improve implant osseointegration, of which the discussions are outlined according to their physical traits, chemical composition, and drug delivery capacity. A perspective is also provided in this review regarding the current limitations and future opportunities of MOF‐coated Ti implants for orthopedic applications. The insights in this review may facilitate the rational design of more advanced Ti implants with enhanced therapeutic performance and safety.

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Section: Mof Coating For Ti Implant Functionalizationmentioning

confidence: 99%

Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Zhang,

Cheng,

Liu

et al. 2023

Advanced Science

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“…MOF‐integrated composites can incorporate antibacterial agents or ions, such as silver nanoparticles or zinc oxide, which exhibit potent antimicrobial activity. [ 101 ]…”

Section: Applications Of Mof‐integrated Composites In Btementioning

confidence: 99%

“…MOF-integrated composites can incorporate antibacterial agents or ions, such as silver nanoparticles or zinc oxide, which exhibit potent antimicrobial activity. [101] The release of these agents from the MOF structure can effectively suppress bacterial and biofilm formation on the implant surface, mitigating the potential for implant-associated infections and associated complications. To address the issue of bacterial infection and implant failure in revision surgeries, a [100] Copyright 2023, Elsevier Inc.…”

Section: Mof-integrated Composites In Orthopedic Implantsmentioning

confidence: 99%

Metal–Organic Framework‐Integrated Composites for Bone Tissue Regeneration

Mi,

Xiong,

Zhao

et al. 2023

Adv Funct Materials

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Metal–organic frameworks (MOFs) exhibit exceptional characteristics, including high porosity and adjustable properties, rendering them highly suitable for biomedical applications. Recently, researchers have directed their attention toward the integration of MOFs into composites for bone tissue regeneration (BTE), presenting distinct advantages over conventional substitutes. In this comprehensive review, the authors delve into the latest advancements concerning MOF‐integrated composites for BTE. This exploration encompasses an examination of the properties of MOFs and the various synthesis techniques employed to fabricate these materials. Furthermore, the diverse applications of MOF‐integrated composites in BTE are investigated, encompassing areas such as antibacterial properties, osteogenic differentiation, angiogenesis, and immunomodulation. By providing a comprehensive overview of the ongoing research on MOF‐integrated composites for BTE, this study holds the promise of yielding innovative solutions within the realm of orthopedics.

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A review of recent developments of metal–organic frameworks as combined biomedical platforms over the past decade

Moharramnejad

Malekshah

Ehsani

et al. 2023

Advances in Colloid and Interface Science

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Stimuli-responsive doxorubicin-loading Zr-MOF film for time-ordered tumor therapy and bone regeneration

Cited by 6 publications

References 37 publications

Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

Metal–Organic Framework‐Integrated Composites for Bone Tissue Regeneration

A review of recent developments of metal–organic frameworks as combined biomedical platforms over the past decade

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