Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation

Shahi, Sina; Roghani‐Mamaqani, Hossein; Talebi, Saeid; Mardani, Hanieh

doi:10.1039/d1py01066b

Cited by 23 publications

(20 citation statements)

References 151 publications

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“…Free-radical polymerization. The manufacture of hydrogels following this route requires the use of synthetic, semi-synthetic or natural hydrophilic polymers [ 218 ]. It is also necessary to use enzymes as catalysts to favor the reaction [ 219 ] or, most commonly, free radical initiators, which are compounds that can generate free radicals by different stimuli.…”

Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Hydrogels are three-dimensional (3D) cross-linked polymeric chains with a high water-absorption capacity [ 26 ]. They can be employed as very efficient, stimuli responsive and biodegradable drug carriers in drug delivery systems [ 27 , 28 ]. Based upon the size of the obtained particles, hydrogels can be classified as macrogels, microgels, and nanogels/nanomatrices.…”

Section: Introductionmentioning

confidence: 99%

Highly Responsive Chitosan-Co-Poly (MAA) Nanomatrices through Cross-Linking Polymerization for Solubility Improvement

Saleem

Akhtar

Minhas

et al. 2022

Gels

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In this study, we report the highly responsive chitosan-based chemically cross-linked nanomatrices, a nano-version of hydrogels developed through modified polymerization reaction for solubility improvement of poorly soluble drug simvastatin. The developed nanomatrices were characterized for solubilization efficiency, swelling studies, sol-gel analysis, in vitro drug release studies, DSC, FTIR, XRD, SEM, particle size analysis, and stability studies. An in vivo acute toxicity study was conducted on female Winstor rats, the result of which endorsed the safety and biocompatibility of the system. A porous and fluffy structure was observed under SEM analysis, which supports the great swelling tendency of the system that further governs the in vitro drug release. Zeta sizer analyzed the particle size in the range of 227.8 ± 17.8 nm. Nano sizing and grafting of hydrophilic excipients to the nanomatrices system explains this shift of trend towards the enhancement of solubilization efficiency, and, furthermore, the XRD results confirmed the amorphous nature of the system. FTIR and DSC analysis confirmed the successful grafting and stability to the system. The developed nanomatrices enhanced the release characteristics and solubility of simvastatin significantly and could be an effective technique for solubility and bioavailability enhancement of other BCS class-II drugs. Due to enhanced solubility, efficient method of preparation, excellent physico-chemical features, and rapid and high dissolution and bio-compatibility, the developed nanomatrices may be a promising approach for oral delivery of hydrophobic drugs.

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“…Scaffold degradation rates and triggers could be further altered and refined using enzyme, oxidation, or photo‐responsive chemistries, as well as more elegant logic‐gating combinations of these cues. [ 37 ] Additional possibilities exist for mixing chemical functionalities on different length scales, that is, within individual microgels, between microgels within a single filament (as is demonstrated in this work), or by separating microgel populations in a multi‐nozzle printer. These approaches and combinations thereof will permit straightforward construction of vascularized structures and sacrificial molds, as well as modular scaffolds with spatially defined chemical, biological, mechanical, and topological characteristics.…”

Section: Resultsmentioning

confidence: 99%

4D Printing of Extrudable and Degradable Poly(Ethylene Glycol) Microgel Scaffolds for Multidimensional Cell Culture

Miksch

Skillin

Kirkpatrick

et al. 2022

Small

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Granular synthetic hydrogels are useful bioinks for their compatibility with a variety of chemistries, affording printable, stimuli‐responsive scaffolds with programmable structure and function. Additive manufacturing of microscale hydrogels, or microgels, allows for the fabrication of large cellularized constructs with percolating interstitial space, providing a platform for tissue engineering at length scales that are inaccessible by bulk encapsulation where transport of media and other biological factors are limited by scaffold density. Herein, synthetic microgels with varying degrees of degradability are prepared with diameters on the order of hundreds of microns by submerged electrospray and UV photopolymerization. Porous microgel scaffolds are assembled by particle jamming and extrusion printing, and semi‐orthogonal chemical cues are utilized to tune the void fraction in printed scaffolds in a logic‐gated manner. Scaffolds with different void fractions are easily cellularized post printing and microgels can be directly annealed into cell‐laden structures. Finally, high‐throughput direct encapsulation of cells within printable microgels is demonstrated, enabling large‐scale 3D culture in a macroporous biomaterial. This approach provides unprecedented spatiotemporal control over the properties of printed microporous annealed particle scaffolds for 2.5D and 3D tissue culture.

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Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation

Abstract: Covalent crosslinked stimuli-destructible hydrogels with the ability of irreversible stimuli-controlled bond dissociation have attracted great attentions due to their easy preparation, biocompatibility, biodegradability, stability against hydrolysis, and controlled solubility by...

Cited by 23 publications

References 151 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Highly Responsive Chitosan-Co-Poly (MAA) Nanomatrices through Cross-Linking Polymerization for Solubility Improvement

4D Printing of Extrudable and Degradable Poly(Ethylene Glycol) Microgel Scaffolds for Multidimensional Cell Culture

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