Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers

Yuan, Ying Xue; Nie, Tianqi; Ying, Fang; You, Xinru; Huang, Hai; Wu, Jun

doi:10.1039/d1tb02683f

Cited by 42 publications

(38 citation statements)

References 173 publications

(300 reference statements)

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“…Cyclodextrin (CD) is a cyclic oligosaccharide obtained from starch by enzymatic hydrolysis, mainly containing 6, 7 and 8 glucopyranose units forming α-CD, β-CD, and γ-CD respectively. α-, β- and γ-CD have hydrophobic cavities with internal diameters of approximately 0.47–0.53, 0.60–0.65 and 0.75–0.83 nm, respectively. − Hydroxyl groups within the cyclodextrins are not only responsible for aqueous solubility but also allow the hydroxyl groups to interact with the hydrophilic components, making the hydrophobic drugs water-soluble complexes. − In this inclusion complexation phenomenon, multiple cyclodextrin fragments can be involved by encapsulating one or more guest molecules, which can form a variety of complexation phenomena such as 1:1, 1:2, 2:2, etc. Therefore, this section is divided into three main sections on cyclodextrin-inclusive drugs, focusing on (1) natural cyclodextrin-inclusive drugs, (2) modified cyclodextrin-inclusive drugs and (3) cyclodextrin polymer-inclusive drugs.…”

Section: Cyclodextrin Nanodrug Carriers Based On Host–guest Systemmentioning

confidence: 99%

Supramolecular Biopharmaceutical Carriers Based on Host–Guest Interactions

Zhang

et al. 2022

J. Agric. Food Chem.

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Traditional drugs have the disadvantages of poor permeability and low solubility, which makes the utilization of pesticides lower and brings many side effects. With the continuous development of supramolecular chemistry in recent years, it has also played an irreplaceable role in the field of pharmaceutical science. Supramolecular macrocycles, such as crown ethers, cyclodextrins, calixarenes, pillararenes and cucurbiturils, are potentially good candidates for drug carriers due to their biocompatibility, hydrophobic cavity and ease of derivatization. The encapsulation of drugs based on host−guest interaction has the advantage of being adjustable and reversible as well as improving the low availability of drugs. Here, the recent advances in methods and strategies for drug encapsulation and release based on supramolecular macrocycles with host−guest interactions have been systematically summarized, laying a bright foundation for the development of novel nanopesticide preparations in the future and pointing out future directions of novel biopesticide research.

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Section: Cyclodextrin Nanodrug Carriers Based On Host–guest Systemmentioning

confidence: 99%

Supramolecular Biopharmaceutical Carriers Based on Host–Guest Interactions

Zhang

et al. 2022

J. Agric. Food Chem.

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“…The role of CDs in pharmaceutical applications has come a long way from being used for masking taste to the current state-of-the-art targeted release ( Yuan et al, 2022 ). The union of CD with nanotechnology has only furthered the capacity of the cyclodextrin-based derivatives.…”

Section: Cyclodextrin Nanoparticles For Anticancer Applicationsmentioning

confidence: 99%

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Karthic

Roy

Lakkakula

et al. 2022

Front. Cell Dev. Biol.

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Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokinetic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems have the caliber to improve the solubility and biocompatibility of various such chemical compounds. In this regard, cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility, and stability, whereas CDs supramolecular chemical compatibility renders it to be highly receptive to various kinds of functionalization. Therefore combining physical, chemical, and bio-engineering approaches at nanoscale to specifically target the tumor cells can help in maximizing the tumor damage without harming non-malignant cells. Numerous combinations of CD nanocomposites were developed over the years, which employed photodynamic, photothermal therapy, chemotherapy, and hyperthermia methods, particularly targeting cancer cells. In this review, we discuss the vivid roles of cyclodextrin nanocomposites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.

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“…Key polymers, such as CD-centric core polymers, CD-side polymers, and CD-terminated polymers, have a variety of applications, including materials fabrication for theranostic nanomedicine. Due to this, cyclodextrin-based polymers have been validated as effective scaffolds in nanomedicine [ 82 , 83 ].…”

Section: Cyclodextrin-based Polymersmentioning

confidence: 99%

Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications

Esmaeilpour

Broscheit

Shityakov

2022

IJMS

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Cyclodextrins (CDs) are cyclic oligosaccharide structures that could be used for theranostic applications in personalized medicine. These compounds have been widely utilized not only for enhancing drug solubility, stability, and bioavailability but also for controlled and targeted delivery of small molecules. These compounds can be complexed with various biomolecules, such as peptides or proteins, via host-guest interactions. CDs are amphiphilic compounds with water-hating holes and water-absorbing surfaces. Architectures of CDs allow the drawing and preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. These polymers can be cloaked with protein corona consisting of adsorbed plasma or extracellular proteins to improve nanoparticle biodistribution and half-life. Besides, CDs have become famous in applications ranging from biomedicine to environmental sciences. In this review, we emphasize ongoing research in biomedical fields using CD-based centered, pendant, and terminated polymers and their interactions with protein corona for theranostic applications. Overall, a perusal of information concerning this novel approach in biomedicine will help to implement this methodology based on host-guest interaction to improve therapeutic and diagnostic strategies.

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Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers

Abstract: Drug delivery systems can achieve diverse functions by integrating the host–guest chemistry of CDs with stimuli-responsive functions.

Cited by 42 publications

References 173 publications

Supramolecular Biopharmaceutical Carriers Based on Host–Guest Interactions

Supramolecular Biopharmaceutical Carriers Based on Host–Guest Interactions

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications

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