Stimuli-responsive cyclodextrin-based nanoplatforms for cancer treatment and theranostics

Yao, Xikuang; Mu, Jing; Zeng, Leli; Lin, Jing; Nie, Zhihong; Jiang, Xiqun; Huang, Peng

doi:10.1039/c9mh00166b

Cited by 64 publications

(33 citation statements)

References 238 publications

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“…[12,14] Up to now hydrophobic drugs can be loaded in hydrogels by functionalizing their networks with hydrophobic domains like cyclodextrin or micelles. [15] This approach presents some drawbacks like the low amount of hydrophobic solute that can be loaded, [16] limiting the application to only drugs that exhibits high therapeutic activity even at low concentrations. Furthermore, Bijels can help overcome one of the main problems of nanomedicine: the uncontrolled distribution of nanoparticles though the body.…”

Section: Introductionmentioning

confidence: 99%

Biphasic Porous Structures formed by Monomer/Water Interface Stabilization with Colloidal Nanoparticles

Pizzetti

Rossetti

Marchetti

et al. 2021

Adv Materials Inter

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Bicontinuous jammed emulsions (known as bijels) are Pickering emulsions where oil and water are both continuous phases. These interconnected structures, stabilized by colloidal nanoparticles at the oil–water interface, have been used in a wide range of applications. Among these, catalysis and encapsulation of solutes has showed promising potential, but the low mechanical properties of the systems limit their use. Here it is proposed that the use of a hydrophobic monomer able to polymerize in bulk and form a biphasic porous structure with polymer and water as immiscible phases. The final system is stabilized by colloidal nanoparticles made of hydroxyapatite, and the system's ability to release both hydrophilic and hydrophobic drugs has been demonstrated. The strategy has been proven to be highly versatile and may be tuned with a diversity of monomers and nanoparticles to satisfy specific industrial and medical needs.

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Section: Introductionmentioning

confidence: 99%

Biphasic Porous Structures formed by Monomer/Water Interface Stabilization with Colloidal Nanoparticles

Pizzetti

Rossetti

Marchetti

et al. 2021

Adv Materials Inter

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“…Current applications focus on site-specific drug/gene delivery and protein separation and analysis. Considering the avant-garde developments in CD chemistry, glycobiology and nanotechnology, a much broader range of progress is expected in the near future from their synergistic blend, including fields as diverse as catalysis [199,200], bioremediation [201], sensing [202][203][204][205], diagnostics [206,207], theranostics [208,209], vaccines [210,211] or personalized medicine [212,213]. Structures and schematic representation of the strategy developed by Riela, Lazzala and coworkers to assemble hybrid glycoCD/halloysite nanotubes to achieve functional glyconanomaterials for the co-administration of curcumin (Cur) and silibinin (Sil) in thyroid cancer cells [196,197].…”

Section: Discussionmentioning

confidence: 99%

Cyclodextrin-Based Functional Glyconanomaterials

2020

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Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

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“…62 CDs have hydrophilic and polar surface, due to the presence of the many hydroxyl groups. This dual-property opened the utilization of CDs in a wide range of areas, including water treatment, 63 separation, chromatography, 64,65 biomedical applications, 66,67 and catalysis. 68 In this section, we highlight the most significant studies of CDs for separation applications.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Engineering membranes with macrocycles for precise molecular separations

et al. 2021

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Stimuli-responsive cyclodextrin-based nanoplatforms for cancer treatment and theranostics

Abstract: Stimuli-responsive cyclodextrin-based nanoplatforms, which can be triggered by different stimuli, such as pH, temperature, redox, enzymes, light and magnetic fields, are summarized for cancer treatment and theranostics.

Cited by 64 publications

References 238 publications

Biphasic Porous Structures formed by Monomer/Water Interface Stabilization with Colloidal Nanoparticles

Biphasic Porous Structures formed by Monomer/Water Interface Stabilization with Colloidal Nanoparticles

Cyclodextrin-Based Functional Glyconanomaterials

Engineering membranes with macrocycles for precise molecular separations

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