Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies

Dhas, Namdev; Kudarha, Ritu; Pandey, Abhijeet; Nikam, Ajinkya Nitin; Sharma, Shilpa; Singh, Ashutosh; Garkal, Atul; Hariharan, Kartik; Singh, Amanpreet; Bangar, Priyanka; Yadhav, Dattatray; Parikh, Dhaivat; Sawant, Krutika; Mutalik, Srinivas; Garg, Neha; Mehta, Tejal

doi:10.1016/j.jconrel.2021.03.021

Cited by 32 publications

(14 citation statements)

References 553 publications

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“…Over the past few decades, magnetic stim [ 379 – 381 ]. Moreover, considering that magnetic nanoparticles have excellent physiochemical performances and biological effects, they have been proposed as ideal platforms for a number of tumor theranostics [ 382 ].…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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“…A further advantage related to SPIONs in biomedicine is ascribed to their capability to bond to several compounds providing specific surface functionality, which is required to the linkage of therapeutic agents, active molecules and stabilizers that confer singular properties in many diagnostic and therapeutic issues. [39] The above-mentioned diagnostic ability, combined with the possibility to induce therapeutic action through drugs loading, hyperthermia, photo and thermotherapy turn these nanoplatforms in the mentioned nanotheranostics. Figure 3 illustrates the structure and functionality of a magnetic nanotheranostic agent.…”

Section: Implementation Of Spions In Biomedicinementioning

confidence: 99%

Novel Insights and Perspectives for the Diagnosis and Treatment of Hearing Loss through the Implementation of Magnetic Nanotheranostics

2022

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Hearing loss (HL) is a sensory disability that affects 5 % of the world's population. HL predominantly involves damage and death to the cochlear cells. Currently, there is no cure or specific medications for HL. Furthermore, the arrival of therapeutic molecules to the inner ear represents a challenge due to the limited blood supply to the sensory cells and the poor penetration of the blood-cochlear barrier. Superparamagnetic iron oxide nanoparticles (SPIONs) perfectly coordinate with the requirements for controlled drug delivery along with magnetic resonance imaging (MRI) diagnostic and monitoring capabilities. Besides, they are suitable tools to be applied to HL, expecting to be more effective and non-invasive. So far, the published literature only refers to some preclinical studies of SPIONs for HL management. This contribution aims to provide an integrated view of the best options and strategies that can be considered for future research punctually in the field of magnetic nanotechnology applied to HL.

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“…To improve the accumulation, there is an urgent desire to decorate such dual-responsive micelles with targeting agents. Iron oxide nanoparticles (IONPs) have been studied for a few decades as multifunctional biomedical materials and extensively applied in cancer diagnosis and therapy. , Due to intrinsic magnetic properties, IONPs are encapsulated into micelles to endow the nanoplatforms with a reliable magnetic targeting ability . More importantly, when exposed to an alternating magnetic field (AMF) and 808 nm laser irradiation, IONPs can separately elicit magnetic hyperthermia therapy (MHT) and photothermal therapy (PTT). − The hyperthermia therapy (HTT; including MHT and PTT) can not only loosen cell membranes and cause irreversible damage for conquering cancer but also lead to the speedy collapse of nanocarriers and rapid diffusion of its cargos. , Therefore, the equipment with IONPs could be rather more attractive to satisfy both targeting and thermal demands while avoiding additional design complexity, which can release its cargos in a controlled manner and thus dramatically boost the therapeutic efficiency of pH/thermal responsive nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

“…Iron oxide nanoparticles (IONPs) have been studied for a few decades as multifunctional biomedical materials and extensively applied in cancer diagnosis and therapy. 23,24 Due to intrinsic magnetic properties, IONPs are encapsulated into micelles to endow the nanoplatforms with a reliable magnetic targeting ability. 25 More importantly, when exposed to an alternating magnetic field (AMF) and 808 nm laser irradiation, IONPs can separately elicit magnetic hyperthermia therapy (MHT) and photothermal therapy (PTT).…”

Section: Introductionmentioning

confidence: 99%

pH/Thermal-Sensitive Nanoplatform Capable of On-Demand Specific Release to Potentiate Drug Delivery and Combinational Hyperthermia/Chemo/Chemodynamic Therapy

Liu

Zuo

et al. 2022

ACS Appl. Mater. Interfaces

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Therapeutic platforms with spatiotemporal control were recently of considerable interest. However, the site-specific regulation of chemotherapeutics release remains an enormous challenge. Herein, a versatile nanoplatform capable of tumor-specific delivery and controlled drug release, coined as PDDFe, was constructed for elevating cancer theranostics. Iron-oxide nanoparticles (IONPs) and doxorubicin (Dox) were encapsulated in pH/thermal-sensitive micelles composed of poly(ethylene)glycol-poly(β-amino esters) and dipalmitoyl phosphatidylcholine to obtain tumor-targeted dual-responsive nanoplatforms. With remarkable magnetic targeting effects, PDDFe specifically accumulated at tumor locations. After internalization by cancer cells, the acidic environment and localized heat generated by hyperthermia therapy would spur PDDFe to become loose and collapse to liberate its payload. In addition to boosting the release, the increased temperature also resulted in direct tumor damage. Meanwhile, the released Dox and IONPs, respectively, stimulated chemotherapy and chemodynamic therapy to jointly destroy cancer, thus leading to a pronounced therapeutic effect. In vivo magnetic resonance/fluorescence/photoacoustic imaging experiments validated that the dual-sensitive nanoplatforms were able to accumulate at the tumor sites. Treatment with PDDFe followed by alternating magnetic field and laser irradiation could prime hyperthermia/chemo/chemodynamic therapy to effectively retard tumor growth. This work presents a nanoplatform with a site-specific controlled release characteristic, showing great promises in potentiating drug delivery and advancing combinational cancer therapy.

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Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies

Cited by 32 publications

References 553 publications

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Novel Insights and Perspectives for the Diagnosis and Treatment of Hearing Loss through the Implementation of Magnetic Nanotheranostics

pH/Thermal-Sensitive Nanoplatform Capable of On-Demand Specific Release to Potentiate Drug Delivery and Combinational Hyperthermia/Chemo/Chemodynamic Therapy

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