Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Jimaja, Sètuhn; Varlas, Spyridon; Foster, Jeffrey C.; Taton, Daniel; Dove, Andrew P.; O’Reilly, Rachel K.

doi:10.1039/d2py00397j

Cited by 7 publications

(5 citation statements)

References 95 publications

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“…The disulfide bonds as stimulus-sensitive functionalities within the micelle network change the size of the nanoparticles due to their cleavage using high concentrations of reducing agents, including decreased glutathione (GSH), thioredoxin, and peroxiredoxin, which are found at various levels of all over the body 32 . GSH as a reducing agent was selected in our degradation experiments 33 . The size change of reduction breakable NPs in response to GSH (10 mM) in PBS buffer (pH = 6.5) was assayed with DLS 34 .…”

Section: Methodsmentioning

confidence: 99%

pH/redox responsive size‐switchable intelligent nanovehicle for tumor microenvironment targeted DOX release

Badparvar,

Marjani,

Salehi

et al. 2023

Sci Rep

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Tumor microenvironment (TME) targeted strategy could control the drug release in tumor cells more accurately and creates a new opportunity for enhanced site-specific targeted delivery. In this study, (PAA-b-PCL-S-S-PCL-b-PAA) copolymeric nanoparticles (NPs) with size-switchable ability and dual pH/redox-triggered drug release behavior were designed to significantly promote cancer uptake (cell internalization of around 100% at 30 min) and site-specific targeted doxorubicin (DOX) delivery in MDA-MB-231 tumor cells. NPs surface charge was shifted from − 17.8 to − 2.4 and their size shrunk from 170.3 to 93 nm in TME. The cell cycle results showed that DOX-loaded NPs showed G2/M (68%) arrest, while free DOX showed sub-G1 arrest (22%). Apoptosis tests confirmed that the cells treated with DOX-loaded NPs showed a higher amount of apoptosis (71.6%) than the free DOX (49.8%). Western blot and RT-PCR assays revealed that the apoptotic genes and protein levels were significantly upregulated using the DOX-loaded NPs vs. the free DOX (Pvalue < 0.001). In conclusion, dual pH/redox-responsive and size-switchable DOX-loaded NPs developed here showed outstanding anti-tumoral features compared with free DOX that might present a prospective platform for tumor site-specific accumulation and drug release that suggest further in vivo research.

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Section: Methodsmentioning

confidence: 99%

pH/redox responsive size‐switchable intelligent nanovehicle for tumor microenvironment targeted DOX release

Badparvar,

Marjani,

Salehi

et al. 2023

Sci Rep

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“…Te sizes of NPs may be controlled in a microemulsion process by altering the moisture content and pH of the micelles [207,208]. In the microemulsion process, the organic solvent layer and surfactant layer efciently separated the precipitated particles and increased particle dispersibility [209,210].…”

Section: Synthetic Procedures For Metal Peroxidesmentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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“…They have produced many supramolecular materials through the self-assembly of simple small molecules inspired by these functional self-assembled superstructures. [5][6][7] Organic conjugated supramolecules have captured the interest of researchers over the last two decades due to their prospective uses in fluorescence imaging, photodynamic therapy, chemosensors, optical devices, and light-emitting devices. Aggregation is a common occurrence observed in most molecular systems with π-π stacking and frequently results in aggregation-caused quenching (ACQ).…”

Section: Introductionmentioning

confidence: 99%

“…As always being inspired by living species material scientists, synthesize simple molecules capable of forming complex supramolecular architectures. They have produced many supramolecular materials through the self‐assembly of simple small molecules inspired by these functional self‐assembled superstructures [5–7] …”

Section: Introductionmentioning

confidence: 99%

Luminogenic and Bactericidal Studies of an Acrylonitrile‐Based AIEgen

De,

Ghosh,

Das

2024

Chemistry An Asian Journal

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We have synthesized an aggregation induced emissive molecule that exhibits promising photophysical characteristics. The aggregating aptitude is demonstrated by binary solvent mixture and it is emissive in both solution and solid state. The luminogenic characteristics are employed in creating fluorescent inks as well as for the detection of nitro antibiotics in biofluids and in solid support. Moreover, the acrylonitrile‐based compound is bactericidal tested on E. coli and B. subtilis.

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Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

Abstract: We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly...

Cited by 7 publications

References 95 publications

pH/redox responsive size‐switchable intelligent nanovehicle for tumor microenvironment targeted DOX release

pH/redox responsive size‐switchable intelligent nanovehicle for tumor microenvironment targeted DOX release

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Luminogenic and Bactericidal Studies of an Acrylonitrile‐Based AIEgen

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