Stimuli‐accelerated polymeric drug delivery systems

Rust, Tarik; Jung, Dimitri; Langer, Klaus; Kuckling, Dirk

doi:10.1002/pi.6474

Cited by 8 publications

(2 citation statements)

References 94 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nucleic acid nanostructures have been engineered to respond to various stimuli, including pH, redox gradient, and light, for drug delivery applications [ 30 ]. Responsive delivery systems based on pH, light, and redox-cleavable polymers have been developed for controlled drug release [ 31 ]. Mesoporous silica nanoparticles (MSNs) with surface silanol groups have been utilized as versatile drug delivery platforms, with stimuli-responsive silanol conjugates enabling precise drug release [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

El Sadda,

Eissa,

Elafndi

et al. 2024

BMC Chemistry

View full text Add to dashboard Cite

Nanocomposites incorporating titanium dioxide (TiO2) have a significant potential for various industrial and medical applications. These nanocomposites exhibit selectivity as antimicrobial and anticancer agents. Antimicrobial activity is crucial for medical uses, including applications in food processing, packaging, and surgical instruments. Additionally, these nanocomposites exhibit selectivity as anticancer agents. A stable nanocomposite as a new anticancer and antibacterial chemical was prepared by coupling titanium dioxide nanoparticles with a polyurethane foam matrix through the thiourea group. The titanium dioxide/thiopolyurethane nanocomposite (TPU/TiO2) was synthesized from low-cost Ilmenite ore and commercial polyurethane foam. EDX analysis was used to determine the elemental composition of the titanium dioxide (TiO2) matrix. TiO2NPs were synthesized and were characterized using TEM, XRD, IR, and UV–Vis spectra. TiO2NPs and TPU foam formed a novel composite. The MTT assay assessed Cisplatin and HepG-2 and MCF-7 cytotoxicity in vitro. Its IC50 values for HepG-2 and MCF-7 were 122.99 ± 4.07 and 201.86 ± 6.82 µg/mL, respectively. The TPU/TiO2 exhibits concentration-dependent cytotoxicity against MCF-7 and HepG-2 cells in vitro. The selective index was measured against both cell lines; it showed its safety against healthy cells. Agar well-diffusion exhibited good inhibition zones against Escherichia coli (12 mm), Bacillus cereus (10 mm), and Aspergillus niger (19 mm). TEM of TPU/TiO2-treated bacteria showed ultrastructure changes, including plasma membrane detachment from the cell wall, which caused lysis and bacterial death. TPU/TiO2 can treat cancer and inhibit microbes in dentures and other items. Also, TPU/TiO2 inhibits E. coli, B. cereus, and A. niger microbial strains.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

El Sadda,

Eissa,

Elafndi

et al. 2024

BMC Chemistry

View full text Add to dashboard Cite

show abstract

“…The introduction of stimulus-responsive chemical groups to nanomedicines is thus a more versatile approach. [25] Tremendous stimuli-responsive polymers capable of responding to the tumor microenvironment signals including pH, [26][27][28] temperature, [29,30] reactive oxy-gen species, [31][32][33] and glutathione (GSH) [34,35] have been developed so far. Of the reported stimuli approaches, the application of GSH-sensitive polymers containing disulfide bridges is of particular importance owing to the distinct difference in the GSH levels between normal cells (≈2 mm) and specific tumor cells (≈10 mm).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Zhang,

Ma,

Wang

et al. 2023

Macro Chemistry & Physics

View full text Add to dashboard Cite

Poly(tertiary amine‐oxide)‐based polymeric nanocarriers have showed more functionalities than stealthy PEG‐based analogs due to the structure of phospholipid affinitive N‐oxides groups, which has attracted considerable attention to the synthesis of various zwitterionic copolymers with tertiary amine‐oxide grafts for enhanced anticancer drug delivery. However, poly(tertiary amine‐oxide)‐based amphiphilic copolymers with tumor intracellular microenvironment sensitivities, to the knowledge, have been rarely reported likely due to the lack of a controlled synthetic strategy. Herein, a reducible zwitterionic copolymer, poly(ε‐caprolactone)25‐SS‐poly(2‐(N‐oxide‐N,N‐diethylamino)ethyl methacrylate)30 (PCL25‐SS‐OPDEA30) is designed and synthesized successfully via combination of controlled polymerization techniques and post polymerization modification. Specifically, postoxidation of poly(tertiary amine) is confirmed to be a better synthetic strategy toward a well‐defined polymer structure relative to direct polymerization of N,N‐diethylaminoethyl methacrylate (ODEA). The effect of disulfide bridges on the self‐assembly behaviors, in vitro drug loading and drug release properties is investigated in detail. Notablely, the resulting micelles self‐assembled from PCL25‐SS‐OPDEA30 show much greater colloidal stability, higher drug loading content (DLC), and better in vitro tumor cell inhibition than the reduction‐insensitive counterparts. Overall, this study reports a robust strategy toward zwitterionic nanomedicines for on‐demand anticancer drug delivery.

show abstract

Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Zhuang,

Li,

Shen

et al. 2024

Aggregate

View full text Add to dashboard Cite

Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching of reactive oxygen species (ROS) and aggregation‐induced generation of ROS, the aggregation effect plays a significant role on the ROS generation of photosensitizers (PSs), which is worthy of in‐depth exploration and full utilization. However, in contrast to the well‐developed researches on the aggregation effect on luminescence, the studies concerning the aggregation effect on ROS generation are currently in a relatively nascent and disjointed stage, lacking guidance from a firmly established research paradigm. To advance this regard, this review aims at providing a consolidated overview of the fundamental principles and research status of aggregation effects on the ROS generation. Here, the research status can be organized into two main facets. One involves the comparison between isolated state and aggregated state, which is mainly conducted by two methods of changing solvent environments and adding adjuvants into a given solvent. The other underscores the distinctions between different aggregate states, consisting of three parts, namely comparison within the same or between different categories based on the classification of single‐component and multicomponent aggregates. In this endeavor, we will present our views on current research methodologies that explore how aggregation affects ROS generation and highlight the design strategies to leverage the aggregation effect to optimize PS regiments. We aspire this review to propel the advancement of phototheranostic platforms and accelerate the clinical implementation of precision medicine, and inspire more contributions to aggregate‐level photophysics and photochemistry, pushing the aggregate science and materials forward.

show abstract

Stimuli‐accelerated polymeric drug delivery systems

Cited by 8 publications

References 94 publications

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

Fabrication of GSH‐Responsive Poly(Tertiary Amine‐Oxide)‐Based Nanomedicines for Enhanced Anticancer Drug Release

Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Contact Info

Product

Resources

About