Stimulatory Effects of Hydroxyl Radical Generation by Ga-Al-As Laser Irradiation on Mineralization Ability of Human Dental Pulp Cells

Matsui, Satoshi; Tsujimoto, Yasuhisa; Matsushima, Kiyoshi

doi:10.1248/bpb.30.27

Cited by 52 publications

(50 citation statements)

References 32 publications

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“…Histological studies have reported that hard tissue formation is enhanced as a reaction of dental pulp to laser light. 16,17 In the present study, the non-immediate effect of Low Intensity Laser, but gradual reduction in sensitivity over a period of 6 months can explain the biomodulation effect.…”

Section: Discussionmentioning

confidence: 50%

Clinical evaluation of desensitizing treatments for cervical dentin hypersensitivity

2009

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The aim of this study was to compare different treatments for dentin hypersensitivity in a 6-month follow-up. One hundred and one teeth exhibiting non carious cervical lesions were selected. The assessment method used to quantify sensitivity was the cold air syringe, recorded by the visual analogue scale (VAS), prior to treatment (baseline), immediately after topical treatment, after 1 week, 1, 3 and 6 months. Teeth were randomly assigned to five groups (n = 20): G1: Gluma Desensitizer (GD); G2: Seal&Protect (SP); G3: Oxa-gel (OG); G4: Fluoride (F); G5: Low intensity laser-LILT (660 nm/3.8 J/cm²/15 mW). Analysis was based on the non-parametric Kruskal-Wallis test that demonstrated statistical differences immediately after the treatment (p = 0.0165). To observe the individual effects of each treatment, data was submitted to Friedman test. It was observed that GD and SP showed immediate effect after application. Reduction in the pain level throughout the six-month follow-up was also observed. In contrast, LILT presented a gradual reduction of hypersensitivity. OG and F showed effects as of the first and third month respectively. It can be concluded that, after the 6-month clinical evaluation, all therapies showed lower VAS sensitivity values compared with baseline, independently of their different modes of action.

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Section: Discussionmentioning

confidence: 50%

Clinical evaluation of desensitizing treatments for cervical dentin hypersensitivity

2009

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“…LPLI has been demonstrated to increase the level of intracellular ROS generation. 31 With LPLI treatment, light is absorbed by endogenous photosensitizers (porphyrins or cytochromes) that dominantly locate at plasma membrane, mitochondria or lysosomes. The photosensitizers' activation results in ROS (1O2, O-2 and H2O2) production.…”

Section: Discussionmentioning

confidence: 99%

Effects of LPLI on microglial phagocytosis in LPS-induced neuroinflammation model

Song

Chen

Zhou

2014

J. Innov. Opt. Health Sci.

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Microglial activation plays an important role in neurodegenerative diseases. Once activated, they have macrophage-like capabilities, which can be bene¯cial by phagocytosis and harmful by secretion of neurotoxins. However, the resident microglia always fail to trigger an e®ective phagocytic response to clear dead cells or A deposits during the progression of neurodegeneration. Therefore, the regulation of microglial phagocytosis is considered a useful strategy in searching for neuroprotective treatments. In this study, our results showed that low-power laser irradiation (LPLI) (20 J/cm 2 ) could enhance microglial phagocytic function in LPS-activated microglia. We found that LPLI-mediated microglial phagocytosis is a Rac-1-dependent actin-based process, that a constitutively activated form of Rac1 (Rac1Q61L) induced a higher level of actin polymerization than cells transfected with wild-type Rac1, whereas a dominant negative form of Rac1 (Rac1T17N) markedly suppressed actin polymerization. In addition, the involvement of Rac1 activation after LPLI treatment was also observed by using a Raichu°uorescence resonance energy transfer (FRET)-based biosensor. We also found that PI3K/Akt pathway was required in the LPLI-induced Rac1 activation. Our research may provide a feasible therapeutic approach to control the progression of neurodegenerative diseases.

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“…The results of clinical studies concerning the various PBM effects have potential, even though they have not yet been clearly demonstrated (105,106). In a study examining the effects of Nd:YAG laser on blood flow in pulp tissue using laser Doppler flowmetry in mandibular canines from 13 human patients, a significant increase of blood flow in the dental pulp was noted in all laserirradiated (30 s at 120-mJ pulses at 10 pulses/s) teeth (105).…”

Section: Future Directionsmentioning

confidence: 99%

“…In a study examining the effects of Nd:YAG laser on blood flow in pulp tissue using laser Doppler flowmetry in mandibular canines from 13 human patients, a significant increase of blood flow in the dental pulp was noted in all laserirradiated (30 s at 120-mJ pulses at 10 pulses/s) teeth (105). Moreover, an in vitro study (106) reported that the mineralization of human dental pulp (HDP) cells is stimulated by laser irradiation. Several animal (74,75,85) and clinical (100) studies have reported favorable or potential formation of reparative dentin following laser therapy.…”

Section: Future Directionsmentioning

confidence: 99%

The use of lasers for direct pulp capping

Komabayashi¹,

Ebihara

Aoki

2015

J Oral Sci

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Direct pulp capping helps extend the life of a diseased tooth by maintaining tooth vitality. Nowadays, lasers are more frequently used during direct pulp capping in the clinic, but their use has not been previously reviewed. This review presents the basic properties of currently available lasers, scientific evidence on the effects of laser application on direct pulp capping, and future directions for this technology. An extensive literature search was conducted in various databases for articles published up to January 2015. Original in vitro, in vivo, and clinical studies, reviews, and book chapters published in English were included. Various laser systems have been increasingly and successfully applied in direct pulp capping. Lasers offer excellent characteristics in terms of hemostasis and decontamination for field preparation during direct pulp capping treatment; however, the sealing of exposed pulp with one of the dental materials, such as calcium hydroxide, mineral trioxide aggregates, and bonded composite resins, is still required after laser treatment. Clinicians should consider the characteristics of each wavelength, the emission mode, irradiation exposure time, power, type of laser tip, and the distance between the laser tip and the surface being irradiated. (J Oral Sci 57, 277-286, 2015)

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Stimulatory Effects of Hydroxyl Radical Generation by Ga-Al-As Laser Irradiation on Mineralization Ability of Human Dental Pulp Cells

Cited by 52 publications

References 32 publications

Clinical evaluation of desensitizing treatments for cervical dentin hypersensitivity

Clinical evaluation of desensitizing treatments for cervical dentin hypersensitivity

Effects of LPLI on microglial phagocytosis in LPS-induced neuroinflammation model

The use of lasers for direct pulp capping

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