Stimulatory Effect of β-glucans on Immune Cells

Kim, Hyungsook; Hong, Jin Tae; Kim, Youngsoo; Han, Sang‐Bae

doi:10.4110/in.2011.11.4.191

Cited by 107 publications

(81 citation statements)

References 46 publications

(46 reference statements)

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“…These results suggest that beta glucan may have a positive effect on hearing improvement when used alone. In the literature, it was discussed that beta glucan does not directly affect cancer cells or infectious microorganisms but shows its biological activities through activation of host immune systems [40]. Long-term follow-up studies, and studies using different doses of beta glucan, are necessary to clarify this effect.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats

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Iraz

et al. 2013

Clin Exp Otorhinolaryngol

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ObjectivesThis experimental study investigated the possible protective effect of beta glucans on amikacin ototoxicity.MethodsThirty-eight rats with normal distortion product otoacoustic emissions (DPOAEs) were divided into four groups. Group K was the control group. Group A was injected intramuscularly (i.m.) with amikacin 600 mg/kg/day between days 1-15. Group AB was given beta glucan gavage 1 mg/kg/day on days 0-15 and given amikacin 600 mg/kg/day i.m. on days 1-15. Group B was administered only beta glucan gavage, 1 mg/kg/day, on days 0-15. The DPOAEs were elicited in different frequency regions between 2,003 and 9,515 Hz, as distortion product diagrams (DPgrams), before and after the medication was administered, in all groups, on days 1, 5, 10, and 15.ResultsNo significant changes in the DPgrams were observed in group K. In group A, significant deterioration was observed at the 8,003 and 9,515 Hz frequencies on day 10, and at the 3,991, 4,557, 5,660, 6,726, 8,003, and 9,515 Hz frequencies on day 15. For group AB, statistically significant deterioration was observed at the 2,824, 8,003, and 9,515 Hz frequencies on day 15. The results for group B showed a significant improvement of hearing at the 2,378, 2,824, 3,363, and 3,991 Hz frequencies on day 1, at the 3,363, 3,991, and 8,003 Hz frequencies on day 10, and at the 8,003 Hz frequency on day 15.ConclusionThis study suggests that amikacin-induced hearing loss in rats may be limited to some extent by concomitant use of beta glucan.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats

Bayındır

Filiz

Iraz

et al. 2013

Clin Exp Otorhinolaryngol

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“…Los β-glucanos de levaduras y hongos, a pesar de poseer enlaces y ramificaciones similares, difieren en la longitud de sus cadenas, siendo más largas en las levaduras. Las diferencias en el tipo de enlace y de ramificación influencian el tamaño de la molécula, su estructura terciaria, su carga eléctrica, su conformación en solución (hélice triple o simple, o espiral aleatoria) y sus propiedades de solubilidad (1,10).…”

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ß-glucanos: ¿qué tipos existen y cuáles son sus beneficios en la salud?

2014

Rev. chil. nutr.

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INTRODUCCIÓNLa importancia de la fibra dietética como parte de una dieta equilibrada para la salud del ser humano está ampliamente reconocida. Los β-glucanos son un tipo de fibra soluble para los cuales se han propuesto efectos sobre la glicemia, los niveles de insulinemia, el colesterol y la inmunidad. Cereales como la cebada y la avena son reconocidos como buenas fuentes de β-glucanos pero también se pueden encontrar en algas y hongos. Asimismo, sus propiedades parecen estar relacionadas con su peso molecular, estructura química y características reológicas, las cuales pueden variar según el origen del β-glucano (1).Debido a sus efectos potenciales sobre la salud, la industria de alimentos ha utilizado cada vez más los β-glucanos para el desarrollo de alimentos funcionales. Además, sus propiedades reológicas han estimulado su incorporación a distintas matrices alimentarias con el objetivo de mejorar la estabilidad, textura y vida útil del alimento, en remplazo de ciertos aditivos o agentes texturizantes artificiales (2).En los cereales, los β-glucanos se encuentran concentradas en las paredes celulares del endospermo, cuyo desarrollo es dependiente de las condiciones geoclimáticas; estas, por lo tanto, inciden en el contenido de β-glucano del cereal. Este es regulado por la enzima β-glucano endohidrolasa (1→3, 1→4), también conocida como licheninasa o 1→3, 1→4 β-glucanasa, cuya función es promover la degradación de la pared celular

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“…Therefore, dietary β‐glucans seem to influence not only the mucus secretion in the gut, but also in carp skin. A mechanistic explanation for the action of beta glucans on mucin composition and release in goblet cells might rely on its complex polysaccharide structure, consisting of a backbone of beta (1‐3) linked β‐ d ‐glucopyranosyl units with β‐(1‐6)‐linked side chains of varying distribution and length (Kim, Hong, Kim, & Han, ), which are recognized by vertebrate immune cells as pathogen associated molecular pattern (Kim et al., ).…”

Section: Discussionmentioning

confidence: 99%

Response of the intestinal mucosal barrier of carp (Cyprinus carpio) to a bacterial challenge by Aeromonas hydrophila intubation after feeding with β‐1,3/1,6‐glucan

Jung‐Schroers¹,

Adamek²,

Harris

et al. 2018

Journal of Fish Diseases

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The effect of dietary β-glucan on the bacterial community in the gut of common carp (Cyprinus carpio) was examined after oral application of Aeromonas hydrophila. Carp received either feed supplemented with 1% MacroGard , a β-1,3/1,6-glucan, or a β-glucan-free diet. Fourteen days after feeding, half of the carp from each group were intubated with 10 colony-forming units (CFU) of a pathogenic strain of A. hydrophila. Gut samples were taken 12 hr to 7 days after application and analysed using microbiological and molecular biological techniques (NGS, RT-PCR-DGGE). The reaction of the mucosa and the microbiota to an A. hydrophila intubation differed in carp fed with β-glucan compared to carp from the control group. In β-glucan fed carp, the total bacterial amount was lower but the number of bacterial species was higher. Bacterial composition was different for carp from both treatment groups. The number of mucin filled goblet cells was reduced in carp fed the β-glucan diet. Mucus was obviously released from the goblet cells and was probably washed out of the gut together with high numbers of bacteria. This might be protective against pathogenic bacteria and, therefore, feeding with β-glucan may provide protection against infections of the gut in carp.

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Stimulatory Effect of β-glucans on Immune Cells

Cited by 107 publications

References 46 publications

Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats

Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats

ß-glucanos: ¿qué tipos existen y cuáles son sus beneficios en la salud?

Response of the intestinal mucosal barrier of carp (Cyprinus carpio) to a bacterial challenge by Aeromonas hydrophila intubation after feeding with β‐1,3/1,6‐glucan

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