Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)

Mikwar, Myy; Navarro‐Martín, Laia; Xing, Lixin; Volkoff, Hélène; Hu, Wei; Trudeau, Vance L.

doi:10.1016/j.peptides.2016.01.007

Cited by 14 publications

(9 citation statements)

References 37 publications

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“…Consistent with our finding, previous data have revealed a correlation between hypothalamic SgII expression and the regulation of food intake because food deprivation in the jerboa is associated with an important increase in the number of EM66‐containing neurones within the ARC . Interestingly, it was recently reported that the other SgII‐derived peptide, secretoneurin, stimulates food intake in the goldfish when injected centrally, and that fasting increases SgIIa mRNA levels in its telencephalon . The presence of two biologically active neuropeptides on the same precursor with opposite effects on feeding behaviour has already been reported for ghrelin and obestatin but, until now, the physiological significance of this mechanism has remained unknown.…”

Section: Discussionsupporting

confidence: 92%

“…12,13 Recently, secretoneurin has been found to stimulate food intake in the goldfish. 14 By contrast, no biological activity has been reported for EM66 until now.…”

Section: Introductionmentioning

confidence: 98%

“…Indeed, secretoneurin has been shown to play a role in the modulation of the inflammatory response and the stimulation of neuronal activity . Recently, secretoneurin has been found to stimulate food intake in the goldfish . By contrast, no biological activity has been reported for EM66 until now.…”

Section: Introductionmentioning

confidence: 99%

“…EM66 was named according to its length (66 amino acids) and its N-and C-terminal glutamic acid and methionine residues, respectively, in the human sequence. [10][11][12][13][14][15][16] EM66 was initially characterised in the human adrenal gland, in gonadotrophs and lactotrophs of the rat pituitary, and in specific rodent hypothalamic nuclei, suggesting that, upon stimulation, EM66 may be released to act as an autocrine, paracrine and/or endocrine factor. 17,18 Clinically, it has been shown that EM66 is present in tumoural chromaffin cells and represents a sensitive diagnostic and pronostic marker of pheochromocytoma.…”

Section: Introductionmentioning

confidence: 99%

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A potential role for the secretogranin II‐derived peptide EM66 in the hypothalamic regulation of feeding behaviour

Trebak

Dubuc

Arabo

et al. 2017

J Neuroendocrinology

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EM66 is a conserved 66-amino acid peptide derived from secretogranin II (SgII), a member of the granin protein family. EM66 is widely distributed in secretory granules of endocrine and neuroendocrine cells, as well as in hypothalamic neurones. Although EM66 is abundant in the hypothalamus, its physiological function remains to be determined. The present study aimed to investigate a possible involvement of EM66 in the hypothalamic regulation of feeding behaviour. We show that i.c.v. administration of EM66 induces a drastic dose-dependent inhibition of food intake in mice deprived of food for 18 hours, which is associated with an increase of hypothalamic pro-opiomelanocortin (POMC) and melanocortin-3 receptor mRNA levels and c-Fos immunoreactivity in the POMC neurones of the arcuate nucleus. By contrast, i.c.v. injection of EM66 does not alter the hypothalamic expression of neuropeptide Y (NPY), or that of its Y1 and Y5 receptors. A 3-month high-fat diet (HFD) leads to an important decrease of POMC and SgII mRNA levels in the hypothalamus, whereas NPY gene expression is not affected. Finally, we show that a 48 hours of fasting in HFD mice decreases the expression of POMC and SgII mRNA, which is not observed in mice fed a standard chow. Taken together, the present findings support the view that EM66 is a novel anorexigenic neuropeptide regulating hypothalamic feeding behaviour, at least in part, by activating the POMC neurones of the arcuate nucleus.

show abstract

Section: Discussionsupporting

confidence: 92%

“…12,13 Recently, secretoneurin has been found to stimulate food intake in the goldfish. 14 By contrast, no biological activity has been reported for EM66 until now.…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A potential role for the secretogranin II‐derived peptide EM66 in the hypothalamic regulation of feeding behaviour

Trebak

Dubuc

Arabo

et al. 2017

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…In goldfish, ICV injections of the SN increase food intake and locomotor behavior (Trudeau et al, 2012), increase mRNA levels of hypothalamic NPY and decrease hypothalamic CART. In addition, fasting increases telencephalon SgII mRNA levels (Mikwar et al, 2016), suggesting that, in fish, SN might act as an orexigenic factor.…”

Section: Hormones Involved In Food Intakementioning

confidence: 99%

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

2016

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Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

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Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin

Fischer‐Colbrie

Theurl

Kirchmair

2017

Chromogranins: From Cell Biology to Physiology and Biomedicine

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Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)

Cited by 14 publications

References 37 publications

A potential role for the secretogranin II‐derived peptide EM66 in the hypothalamic regulation of feeding behaviour

A potential role for the secretogranin II‐derived peptide EM66 in the hypothalamic regulation of feeding behaviour

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin

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