Stimulatory effect of naloxone on plasma cortisol in human: Possible direct stimulatory action at the adrenal cortex

Coiro, V.; Volpi, R.; Stella, Adriano; Venturi, Nicola; Chiodera, P.

doi:10.1016/j.regpep.2010.08.008

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Likewise, administration of NALT significantly increased ACTH and cortisol levels in rhesus monkeys (Williams et al, ) and women smokers (Roche et al, ). Similarly, administration of naloxone exerted significant increase in circulating cortisol levels in a group of human patients with hypothalamo–pituitary disconnection (Coiro et al, ) indicating direct effects of opioid receptor antagonists on cortisol secretion at the adrenal gland level. In the present study, treatment of lower doses of β‐EP (0.5 or 1.5 µg) did not cause significant change in the serum levels of cortisol, whereas these levels were significantly lower in 4 µg β‐EP‐treated group compared to experimental controls.…”

Section: Discussionmentioning

confidence: 94%

“…To the best of our knowledge, the present study revealed the suppression of serum cortisol levels due to β‐EP treatment for the first time in fish. On the other hand, although number of studies have shown increased cortisol/corticosterone levels due to naloxone/NALT treatment in other vertebrates (Zerani and Gobbetti, ; Williams et al, ; Roche et al, ; Coiro et al, ) under normal conditions, cortisol response to NALT treatment under stressful conditions was not investigated in any vertebrate taxa. In the current study, the serum concentration of cortisol did not show significant increase in stress + NALT‐treated group compared to treatment controls, whereas its level was several fold higher in stress group alone.…”

Section: Discussionmentioning

confidence: 99%

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β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

Chabbi

Ganesh

2013

J. Exp. Zool.

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The opioid peptide β-endorphin (β-EP) is known to play modulatory role in vertebrate reproduction. The objective of the present study was to determine the influence of β-EP and the opioid receptor antagonist naltrexone (NALT) on follicular development in normal, and stressed female tilapia Oreochromis mossambicus. Administration of 4 µg β-EP, but not 0.5 or 1.5 µg β-EP daily for 22 days caused a significant reduction in the mean GSI, HSI, and number of Stage IV (vitellogenic) follicles compared to experimental controls during the prespawning phase of the ovarian cycle. Furthermore, the Stage V (vitellogenic) follicles were completely absent during the prespawning phase concomitant with the significantly lower serum levels of estradiol and cortisol in 4 µg β-EP treated fish compared to experimental controls. On the other hand, exposure of the fish to mild acute stressors for 22 days caused changes in the ovary similar to that of high dose of β-EP, whereas administration of NALT attenuated these effects. The results reveal that β-EP exerts inhibitory effect on the vitellogenic follicular growth through the suppression of ovarian steroidogenesis. The study provides evidence for the opioidergic mediation of the ovarian stress response for the first time in fish.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

Chabbi

Ganesh

2013

J. Exp. Zool.

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“…Evidence in support of the direct effects of opioids on the adrenal glands, independent from their effect on the HPA axis, has been reported in humans. Since such studies are complicated by the inevitable influence of the central effects on the central nervous system and, in particular, on the hypothalamus, a group of patients with hypothalamic-pituitary disconnection due to various pathological conditions (including craniopharyngioma, chordoma, suprasellar meningioma, or pituitary macroadenoma) was enrolled in a study [89]. In these patients, the administration of naloxone increased circulating cortisol but not ACTH levels when compared to control patients administered saline solution.…”

Section: Experimental Evidence Of the Peripheral Effects Of Opioidsmentioning

confidence: 99%

A Closer Look at Opioid-Induced Adrenal Insufficiency: A Narrative Review

Coluzzi

LeQuang

Sciacchitano

et al. 2023

IJMS

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Among several opioid-associated endocrinopathies, opioid-associated adrenal insufficiency (OIAI) is both common and not well understood by most clinicians, particularly those outside of endocrine specialization. OIAI is secondary to long-term opioid use and differs from primary adrenal insufficiency. Beyond chronic opioid use, risk factors for OIAI are not well known. OIAI can be diagnosed by a variety of tests, such as the morning cortisol test, but cutoff values are not well established and it is estimated that only about 10% of patients with OIAI will ever be properly diagnosed. This may be dangerous, as OIAI can lead to a potentially life-threatening adrenal crisis. OIAI can be treated and for patients who must continue opioid therapy, it can be clinically managed. OIAI resolves with opioid cessation. Better guidance for diagnosis and treatment is urgently needed, particularly in light of the fact that 5% of the United States population has a prescription for chronic opioid therapy.

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“…[66][67][68] Direct effects on the adrenal function have also been suggested, as administration of naloxone in patients with hypothalamo-pituitary disconnection resulted to higher levels of cortisol (but not of ACTH) compared with saline infusion. 69 The inhibitory action is evident in both acute and chronic use.…”

Section: Hypothalamo-pituitary-adrenal Axismentioning

confidence: 99%

Opioid-induced endocrinopathies

Fountas

Uum

Karavitaki

2020

The Lancet Diabetes & Endocrinology

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ΤAs the use of opioids is becoming a global epidemic and has led to a rise in expanding, so has the occurrence and recognition of their impact consequences on the endocrine system. Nonetheless, opioid-induced endocrinopathies still remain under-diagnosed, mainly due to symptom under-reporting by patients and lack of awareness in clinicians. Hypogonadism is the most well recognised consequence but These include hypogonadism, inhibitory effects on the hypothalamo-pituitary-adrenal axis and negative impact on bone health also require attention.. Hyperprolactinaemia may also be detected, whereas, clinically relevant thyroid dysfunction has not been identified. EThe effects on other hormones have not been as yet clearly defined. At present, consensus or evidence-based guidelines on how to diagnose and manage these endocrinopathies are lacking. ANonetheless, assessment of gonadal and adrenal function (particularly if in the presence of high index of clinical suspicion), and, as well as evaluation of bone health are advised in these patients. Discontinuation or reduction of the opioid dose and appropriate hormone replacement are management approaches for hypogonadism and hypoadrenalism. Further research is needed to fully elucidate the impact of opioids at all levels of the endocrine system and the optimal management of their consequences.Further research facilitating the development of evidence-based guidelines on the diagnosis and optimal management of opioid-induced endocrinopathies is eagerly awaited.

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Stimulatory effect of naloxone on plasma cortisol in human: Possible direct stimulatory action at the adrenal cortex

Cited by 10 publications

References 7 publications

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

A Closer Look at Opioid-Induced Adrenal Insufficiency: A Narrative Review

Opioid-induced endocrinopathies

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