Stimulatory effect of exogenous diadenosine tetraphosphate on insulin and glucagon secretion in the perfused rat pancreas

Silvestre, Ramona A.; Rodriguez-Gallardo, J.; Egido, Eva M.; Marco, José

doi:10.1038/sj.bjp.0702837

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Diadenosine tetraphosphate (Ap 4 A) stimulated glucagon (as well as insulin) secretion in perfused rat pancreas (Silvestre et al 1999). Expression and functional studies on mice a-cells show that they express P2 receptors.…”

Section: A-cellsmentioning

confidence: 99%

Purinergic signalling in the pancreas in health and disease

Burnstock

Novak²

2012

Journal of Endocrinology

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Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine calls, as well as in stromal cells. The pancreas, especially the endocrine cells, were an early target for the actions of ATP. After the historical perspective of purinergic signalling in the pancreas, the focus of this review will be the physiological functions of purinergic signalling in the regulation of both endocrine and exocrine pancreas. Next, we will consider possible interaction between purinergic signalling and other regulatory systems and their relation to nutrient homeostasis and cell survival. The pancreas is an organ exhibiting several serious diseases -cystic fibrosis, pancreatitis, pancreatic cancer and diabetes -and some are associated with changes in life-style and are increasing in incidence. There is upcoming evidence for the role of purinergic signalling in the pathophysiology of the pancreas, and the new challenge is to understand how it is integrated with other pathological processes.

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Section: A-cellsmentioning

confidence: 99%

Purinergic signalling in the pancreas in health and disease

Burnstock

Novak²

2012

Journal of Endocrinology

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“…In mouse pancreatic α cells ATP inhibited Ca 2+ signaling and glucagon secretion [325] whereas ATP stimulated small increases in glucagon secretion in human, monkey, and mouse islets, whereby a subset of human α cells expressed P2X4Rs [278]. In addition to mononucleotides, the dinucleoside polyphosphate diadenosine tetraphosphate (Ap 4 A), which can act on a variety of nucleotide receptors [326], stimulated both glucagon and insulin release from rat pancreas perfused with varying glucose concentrations [280]. Possibly, Ap 4 A is contained in glucagon-containing granules and released from islet cells similar to granules from chromaffin cells [327].…”

Section: Hormones From Pancreatic Isletsmentioning

confidence: 99%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in the control of numerous (patho)physiological mechanisms. They provoke nucleotide receptor-mediated mechanisms in select target cells. But nucleotides can considerably expand their range of action. They function as primary messengers in intercellular communication by stimulating the release of other extracellular messenger substances. These in turn activate additional cellular mechanisms through their own receptors. While this applies also to other extracellular messengers, its omnipresence in the vertebrate organism is an outstanding feature of nucleotide signaling. Intercellular messenger substances released by nucleotides include neurotransmitters, hormones, growth factors, a considerable variety of other proteins including enzymes, numerous cytokines, lipid mediators, nitric oxide, and reactive oxygen species. Moreover, nucleotides activate or co-activate growth factor receptors. In the case of hormone release, the initially paracrine or autocrine nucleotide-mediated signal spreads through to the entire organism. The examples highlighted in this commentary suggest that acting as ubiquitous triggers of intercellular messenger release is one of the major functional roles of extracellular nucleotides. While initiation of messenger release by nucleotides has been unraveled in many contexts, it may have been overlooked in others. It can be anticipated that additional nucleotide-driven messenger functions will be uncovered with relevance for both understanding physiology and development of therapy.

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“…Diadenosine tetraphosphate stimulated glucagon and insulin secretion in perfused rat pancreas [486]. Studies on mice α-cells showed that they expressed P2 receptors.…”

Section: α-Cellsmentioning

confidence: 99%

Purinergic signalling in endocrine organs

Burnstock

2013

Purinergic Signalling

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There is widespread involvement of purinergic signalling in endocrine biology. Pituitary cells express P1, P2X and P2Y receptor subtypes to mediate hormone release. Adenosine 5′-triphosphate (ATP) regulates insulin release in the pancreas and is involved in the secretion of thyroid hormones. ATP plays a major role in the synthesis, storage and release of catecholamines from the adrenal gland. In the ovary purinoceptors mediate gonadotrophin-induced progesterone secretion, while in the testes, both Sertoli and Leydig cells express purinoceptors that mediate secretion of oestradiol and testosterone, respectively. ATP released as a cotransmitter with noradrenaline is involved in activities of the pineal gland and in the neuroendocrine control of the thymus. In the hypothalamus, ATP and adenosine stimulate or modulate the release of luteinising hormone-releasing hormone, as well as arginine-vasopressin and oxytocin. Functionally active P2X and P2Y receptors have been identified on human placental syncytiotrophoblast cells and on neuroendocrine cells in the lung, skin, prostate and intestine. Adipocytes have been recognised recently to have endocrine function involving purinoceptors.

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Stimulatory effect of exogenous diadenosine tetraphosphate on insulin and glucagon secretion in the perfused rat pancreas

Cited by 6 publications

References 29 publications

Purinergic signalling in the pancreas in health and disease

Purinergic signalling in the pancreas in health and disease

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Purinergic signalling in endocrine organs

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