Stimulatory effect of apigenin-6-C-β-l-fucopyranoside on insulin secretion and glycogen synthesis

Cazarolli, Luisa Helena; Folador, Poliane; Moresco, Henrique Hunger; Brighente, Inês Maria Costa; Pizzolatti, Moacir Geraldo; Silva, Fátima Regina M. Barreto

doi:10.1016/j.ejmech.2009.07.001

Cited by 55 publications

(21 citation statements)

References 44 publications

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“…Identification of these flavonoids were carried out by interpretation of their spectral data as well as by comparison with data reported in the literature (Cazarolli et al, 2009b;Suzuki et al, 2003;Araho et al, 2005). Analysis of the n-BuOH fraction (10.2 g) followed the same chromatographic procedure.…”

Section: Extraction and Isolationmentioning

confidence: 99%

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Moresco¹,

Queiroz²,

Pizzolatti³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The liquid-liquid partitioning of a crude hydroalcoholic extract of Averrhoa carambola L., Oxalidaceae, leaves led to the isolation of a sterol and three flavone C-glycosides. From the n-hexane fraction β-sitosterol was isolated and from the ethyl acetate fraction apigenin-6-C-β-L-fucopyranoside (1) and apigenin- (3) was isolated from the n-butanol fraction. Compound 3 is new, while 1 and 2 have been previously isolated from A. carambola. The antioxidant activity was measured using the DPPH radical scavenging assay and reducing power of iron (III) to iron (II) ions. The ethyl acetate and n-butanol fractions showed the most antioxidant activity. As evaluated by ability of the sample to scavenge DPPH the IC50 values were 90.92 and 124.48 µg/ mL, respectively. In the assay of reducing power these fractions presented 135.64 and 125.12 of ascorbic acid equivalents, respectively. The antioxidant activity exhibited a significant relationship with the phenolic content (r 2 = 0.997), but a poor relationship with the flavonoids content (r 2 = 0.424). The n-hexane fraction was the only fraction to present good toxicity using A. salina with LC50 800.2 μg/mL.

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Section: Extraction and Isolationmentioning

confidence: 99%

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Moresco¹,

Queiroz²,

Pizzolatti³

et al. 2012

Rev. bras. farmacogn.

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“…) isolated from Averrhoa carambola , also showed antidiabetic potential. When administered to hyperglycemic Wistar rats (50 mg/kg), both flavonoids significantly reduced plasma glucose levels . The d ‐fucosyl derivative promoted glucose uptake in soleus muscle, and led to a substantial increase in glycogen levels in muscle and liver tissues by enhancing cellular insulin signaling pathways.…”

Section: Unveiling Natural Leadsmentioning

confidence: 99%

“…The enantiomer 6‐(β‐ l ‐fucosyl)apigenin was found to induce muscular glycogen synthesis in normoglycemic rats, involving the inactivation of GSK‐3. Moreover, it enhanced glucose‐induced insulin secretion . Whether both enantiomers exert similar or complementary antidiabetic effects still needs to be clarified.…”

Section: Unveiling Natural Leadsmentioning

confidence: 99%

Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential

Matos

Macedo²,

Rauter

2017

Medicinal Research Reviews

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Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two age-related amyloid diseases that affect millions of people worldwide. Broadly supported by epidemiological data, the higher incidence of AD among type 2 diabetic patients led to the recognition of T2D as a tangible risk factor for the development of AD. Indeed, there is now growing evidence on brain structural and functional abnormalities arising from brain insulin resistance and deficiency, ultimately highlighting the need for new approaches capable of preventing the development of AD in type 2 diabetic patients. This review provides an update on overlapping pathophysiological mechanisms and pathways in T2D and AD, such as amyloidogenic events, oxidative stress, endothelial dysfunction, aberrant enzymatic activity, and even shared genetic background. These events will be presented as puzzle pieces put together, thus establishing potential therapeutic targets for drug discovery and development against T2D and diabetes-induced cognitive decline-a heavyweight contributor to the increasing incidence of dementia in developed countries. Hoping to pave the way in this direction, we will present some of the most promising and well-studied drug leads with potential against both pathologies, including their respective bioactivity reports, mechanisms of action, and structure-activity relationships.

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“…Our previous studies and other publications have reported the isolation and identification of some compounds such as β-sitosterol, lupeol, 1,5-dihydroxy-6,7-dimethoxy-2-methyl- anthraquinone 3- O - β -glucopyranoside, 3,4,5-trimethoxyphenol-1- O - β - D -glucopyranoside, benzyl-1-O-β-D-glucopyranoside, (+)-5'-methoxyisolariciresinol 3α- O-β - D -gluco- pyranoside, and (+)-isolariciresinol 3α- O-β - D -glucopyranoside[19,20]. ACLR leaf and root extracts have also demonstrated hypoglycaemic, hypotriglyceridemic, anti-lipid peroxidative and anti-atherogenic effects in STZ-induced diabetic rats (or mice)[21,22]. …”

Section: Introductionmentioning

confidence: 99%

Lyoniresinol 3α-O-β-D-Glucopyranoside-Mediated Hypoglycaemia and Its Influence on Apoptosis-Regulatory Protein Expression in the Injured Kidneys of Streptozotocin-Induced Mice

Wen

Liang

et al. 2013

PLoS ONE

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Averrhoa carambola L. (Oxalidaceae) root (ACLR) has a long history of use in traditional Chinese medicine for treating diabetes and diabetic nephropathy (DN). (±)-Lyoniresinol 3α-O-β-D-glucopyranoside (LGP1, LGP2) were two chiral lignan glucosides that were isolated from the ACLR. The purpose of this study was to investigate the effect of LGP1 and LGP2-mediated hypoglycaemia on renal injury in streptozotocin (STZ)-induced diabetic mice. STZ-induced diabetic mice were administrated LGP1 and LGP2 orally (20, 40, 80 mg/kg body weight/d) for 14 days. Hyperglycaemia and the expression of related proteins such as nuclear factor-κB (NF-κB), caspase-3, -8, -9, and Bcl-associated X protein (Bax) were markedly decreased by LGP1 treatment. However, LGP2 treatment had no hypoglycaemic activity. Diabetes-dependent alterations in the kidney such as glomerular hypertrophy, excessive extracellular matrix amassing, and glomerular and tubular basement membrane thickening were improved after 14 days of LGP1 treatment. B cell lymphoma Leukaemia-2 (Bcl-2) expression was reduced in the STZ-induced diabetic mouse kidneys but was enhanced by LGP1 treatment. These findings suggest that LGP1 treatment may inhibit diabetic nephropathy progression and may regulate several pharmacological targets for treating or preventing diabetic nephropathy.

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Stimulatory effect of apigenin-6-C-β-l-fucopyranoside on insulin secretion and glycogen synthesis

Cited by 55 publications

References 44 publications

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Chemical constituents and evaluation of the toxic and antioxidant activities of Averrhoa carambola leaves

Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential

Lyoniresinol 3α-O-β-D-Glucopyranoside-Mediated Hypoglycaemia and Its Influence on Apoptosis-Regulatory Protein Expression in the Injured Kidneys of Streptozotocin-Induced Mice

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