Stimulatory and Inhibitory Effects of Purified Hypothalamic Extracts on Growth Hormone Release From Rat Pituitary in Vitro

Octreotide

“…1 This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids. 2 Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion.…”

Somatostatin Depletion by Cysteamine Increases Somatostatin Binding and Growth Hormone‐Releasing Factor Messenger Ribonucleic Acid in the Arcuate Nucleus

“…The ultradian rhythm of growth hormone (GH) secretion (1) is a result of a complex interplay between two hypophysiotropic hormones: one inhibitory, SRIF (2,3) and the other stimulatory, GRF (4)(5)(6)(7). In addition to their direct effect at the pituitary level, SRIF and G R F exhibit reciprocal interactions in the hypothalamus itself.…”

Somatostatin receptor expression in hepatocellular carcinoma: prognostic and therapeutic considerations

“…Somatostatin (SST) was first described in 1968 as a hormone secretion inhibitor molecule (Krulich et al 1968) and was later found to be coded by a unique human gene (SST) on the short arm of chromosome 3. The SST protein has two active forms produced by alternative cleavage of a single pre-protein: one of 14 amino acids (SST14) and the other of 28 amino acids (SST28), which differ in their potency rather than in their function (see Table 1) (Benoit et al 1990).…”