Stimulator Design of Retinal Prosthesis

Ohta, Jun; Noda, Toshihiko; Shodo, Kenzo; Terasawa, Yasuo; Haruta, Makito; Sasagawa, Kiyotaka

doi:10.1587/transele.e100.c.523

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…The cathodic-first stimulation is the most commonly used waveform for retinal stimulation; it is a biphasic stimulation that is preceded by a negative stimulation. 18,28) The negative stimulation depolarizes the neurons in the vicinity of the stimulation electrode, and the subsequent positive stimulation hyperpolarizes the neurons in the vicinity. Furthermore, electrode damage and electrolysis can be prevented by releasing the accumulated charge in the electrode by applying the negative current with the positive current.…”

Section: Current Generator Circuitmentioning

confidence: 99%

“…Intraocular implantable devices with stimulator circuits and multiplexers using lowpower complementary metal-oxide-semiconductor (CMOS) integrated circuits were developed to overcome this problem. [17][18][19][20][21][22][23][24][25] In our previous works, we have developed retinal prosthesis devices for STS that can be driven using only four wires regardless of the number of stimulation electrodes. [20][21][22][23][24][25] Figure 1 presents a conceptual schematic diagram of the implantable devices used for an STS retinal prosthesis.…”

Section: Introductionmentioning

confidence: 99%

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Implantable AC-driven CMOS chip for distributed multichip retinal prosthesis capable of high-rate stimulation

Nakanishi¹,

Sasagawa²,

Siwadamrongpong³

et al. 2023

Jpn. J. Appl. Phys.

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Implantable retinal prostheses are stimulation devices used to compensate for the light sensitivity loss of retinal cells. In this study, we propose and demonstrate a novel method to significantly reduce the setting time for the stimulation conditions of a retinal prosthesis chip capable of multi-electrode stimulation. The efficiency of the control method is increased while using only two wires, as in our previous work. The chip comprises an 8 bit ID and 7 electrodes, and the stimulation current value can be set from 50 to 1550 μA. The fabricated chip requires only 32 pulses to set the stimulation conditions, which is approximately 1/65 of that of our previous chip. Furthermore, it is equipped with a complementary metal–oxide–semiconductor rectifier to enable it to be driven by a rectangular AC power supply. The effectiveness of the chip is demonstrated by setting the stimulation conditions at approximately 18 μs per electrode at a clock frequency of 2.3 MHz.

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Section: Current Generator Circuitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implantable AC-driven CMOS chip for distributed multichip retinal prosthesis capable of high-rate stimulation

Nakanishi¹,

Sasagawa²,

Siwadamrongpong³

et al. 2023

Jpn. J. Appl. Phys.

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“…To resolve this wiring problem, we proposed and developed a new device referred to as a "smart electrode device". [15][16][17][18][19][20][21][22][23][24][25] This device integrates a CMOS chip with an individual ID, a decoder, a current source, and an electrode selection circuit into the implantable electrode array within the eye. We can significantly reduce the number of external wiring connections by incorporating ICs into the implantable device.…”

Section: Introductionmentioning

confidence: 99%

Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

Nakanishi,

Sriitsaranusorn,

Hattori

et al. 2024

Jpn. J. Appl. Phys.

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We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The CMOS chip integrates current sources and electrode selection circuits. This integration enables stimulation current control from multiple electrodes with minimal wires. In this study, we constructed a validation system with 49 electrodes capable of visually observing stimulation current outputs. The validation results show that it is possible to configure stimulation conditions in approximately 9.3 μs per electrode, and we demonstrated the ability to complete one frame, including the stimulation time, within approximately 11 ms. We also demonstrated parallel current stimulation from multiple electrodes using an in vitro experiment.

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“…To realise an STS system for a wide field of view, we developed a smart electrode device that comprises distributed CMOS chips. Because the stimulation signal for many electrodes is controlled directly by the CMOS chips, it has the advantage of being able to be operated using only a few wires [15–18].…”

Section: Introductionmentioning

confidence: 99%

AC power supply circuit architecture for a miniaturised retinal prosthesis device

Mori

Chang

Endo

et al. 2021

J. eng.

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This study proposes an alternating current (AC)‐driven retinal prosthesis device using an implantable CMOS‐LSI chip that can control multiple electrodes. The proposed device uses AC power with the electrical grounds of the main and stimulation units separated to reduce the possibility of current leakage and to improve safety. The stimulation unit implanted in the eye cannot include large capacitor chips for ground separation. To solve this problem, large capacitor chips are mounted on the implantable control unit that supplies power, not on the stimulating device, and a cooperative mode of operation is devised. In this way, it is realised that a circuit configuration that achieves both miniaturisation and improved power supply efficiency. This study verifies the functionality of the proposed circuit. The results suggest that power supply and stimulation operations are possible through coupling capacitors. In addition, this stimulation operation can be performed continuously.

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Stimulator Design of Retinal Prosthesis

Cited by 8 publications

References 12 publications

Implantable AC-driven CMOS chip for distributed multichip retinal prosthesis capable of high-rate stimulation

Implantable AC-driven CMOS chip for distributed multichip retinal prosthesis capable of high-rate stimulation

Demonstration of multi-point stimulation with AC-driven CMOS chips for retinal prosthesis

AC power supply circuit architecture for a miniaturised retinal prosthesis device

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