Stimulation of Tau Degradation

Quintanilla, Rodrigo A.; Cabezas-Opazo, Fabian; Pallo, Susanne P.; Chesser, Adrianne S.; Johnson, Gail V.W.

doi:10.1016/b978-0-12-802173-6.00013-7

Cited by 2 publications

(1 citation statement)

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“…The HSPA8 gene codes for Hsc70 (known as heat shock cognate 71 kDa protein), which is 86% identical to Hsp70 encoded by HSPA1A [ 53 ]. The expression of HSPA8 was not affected by heat stress; indeed, Hsc70 is constitutively expressed, having a key role in the cell in protein folding and unfolding, and it can be considered as a housekeeping gene [ 53 , 54 ]. As expected, Hsp70 was highly expressed during heat stress.…”

Section: Resultsmentioning

confidence: 99%

Effect of Heat Stress on Dairy Cow Performance and on Expression of Protein Metabolism Genes in Mammary Cells

Corazzin

Saccà

Lippe

et al. 2020

Animals

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The aim of this study was to assess the effect of heat stress on dairy cow performance and on the expression of selected genes involved in milk protein metabolism. Eight Italian Holstein Friesian cows were kept under thermoneutral conditions (temperature–humidity index (THI) < 72, CON) for 8 days and under mild heat stress conditions (72 < THI < 78, HS) for an additional 8 days. The rectal temperature, feed intake, and milk yield were recorded during the last 3 days of the CON and HS periods. During the same time period, milk samples were collected to assess the composition and expression of selected genes involved in milk protein metabolism. Gene expression analyses were performed on somatic cells from milk, which are representative of mammary tissue. In terms of dairy cow performance, HS resulted in lower milk and protein yields and feed intake but higher rectal temperature than for CON (p < 0.05). Under HS, there were greater abundances of HSPA1A (p < 0.05) and BCL2 (p < 0.05), compared to CON, but similar levels of CSN2 (p > 0.05), CSN3 (p > 0.05), HSPA8 (p > 0.05), and STAT5B (p > 0.05) mRNA. Mild heat stress reduced the performance of dairy cows without affecting the expression of genes coding for caseins.

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Section: Resultsmentioning

confidence: 99%